Article
Metallurgy & Metallurgical Engineering
Emin Ender Celebi
Summary: A novel orthophosphoric acid stripping (OpaS) system has been developed for the efficient stripping and crystallization of lithium from lithium enolate in kerosene. This method maximizes lithium yield and crystallization quality without the need for thermal or chemical processes.
Article
Chemistry, Organic
Xiaoyu Liu, Haidong Deng, Yingjun Jiang, Yang Cao, Zhe Wang, Xiaozhen Jiao, Ping Xie
Summary: Commiphorane C, Commiphorane D, and their isomers were synthesized through a linear synthesis strategy in 14 steps. The biological evaluation showed that they can attenuate the overproduction of fibronectin, collagen I, and alpha-SMA in rat renal proximal tubular cells induced by TGF-beta 1.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Xiaoyu Liu, Haidong Deng, Yingjun Jiang, Yang Cao, Zhe Wang, Xiaozhen Jiao, Ping Xie
Summary: (+/-) Commiphorane C, (+/-) commiphorane D, and their two isomers were successfully synthesized through a linear synthesis strategy. Biological evaluation revealed that some compounds could attenuate the overproduction of fibronectin, collagen I, and alpha-SMA, and exhibited low cytotoxicity.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Jun Koizumi, Kaoru Tanaka, Keisuke Fukaya, Daisuke Urabe
Summary: In this study, a synthetic route to the fragments of Amphidinolide L was developed via the Li-mediated stereocontrolled aldol reaction. The structure of the macrolide was partially determined, and the reaction mechanism was studied in detail.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemical Research Methods
Yu-Sheng Sung, Joshua Putman, Siqi Du, Daniel W. Armstrong
Summary: Carboxypeptidases are enzymes that cleave the peptide bond of C-terminal amino acids. This study demonstrates that the addition of 6-aminoquinoline-N-hydroxysuccinimidyl carbamate (AQC) as an N-blocking group greatly enhances substrate hydrolysis with carboxypeptidase. The study also highlights the resistance of D-amino acids within peptides to enzymatic hydrolysis by Carboxypeptidase Y, which could be advantageous for screening low abundance peptide stereoisomers.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yohei Shimizu, Motomu Kanai
Summary: In this article, we discuss the boron-catalyzed alpha-functionalizations of carboxylic acids developed in our group, including five reaction types. The reversible boron carboxylate formation plays a crucial role in the acidification of alpha-protons and enolization using mild organic bases, enabling chemoselective and asymmetric bond formations of carboxylic acids. We summarize the ligand effects on reactivity and stereoselectivity, substrate scopes, and mechanistic insights.
Article
Chemistry, Multidisciplinary
Udaya B. Rao Khandavilli, Aoife M. Buckley, Anita R. Maguire, Mangalampalli S. R. N. Kiran, Upadrasta Ramamurty, Simon E. Lawrence
Summary: This study highlights the significant impact of relative stereochemistry on the mechanical properties of epimer compounds, showing that crystals with different stereochemistry exhibit varying levels of hardness, elastic modulus, and fracture toughness. The brittle crystals have higher values for hardness and elastic moduli compared to the ductile ones due to distinct crystal structural features. Indentation fracture toughness values for the (2'S) crystals are higher than typical values for molecular crystals, attributed to the corrugated nature of their crystal packing.
Article
Chemistry, Organic
Arun K. Ghosh, John P. Gulliver
Summary: The asymmetric aldol reactions between ester-derived chiral auxiliary and bidentate aromatic aldehydes have been investigated, leading to the synthesis of syn-aldol products with high diastereoselectivity and isolated yields. The enantiomers of optically active hydroxy carboxylic acids were obtained through the mild saponification of the chiral auxiliary.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Organic
Sushree Ranjan Sahoo, Debayan Sarkar, Prathap Somu, Subhankar Paul, Peter Lonnecke
Summary: The addition of boron trifluoride etherate to allenic ketones resulted in the isolation of isolated boron difluoride enolates, whose crystal structure has been determined. The migration of (Z)-beta-difluoroboryloxy ether derivatives from C-1 to C-10 has been observed, leading to rearranged phenol derivatives that can be further functionalized into C-2 alkyl-chromenones. Interestingly, the isolated boron enolates show significant anticancer properties.
Review
Chemistry, Multidisciplinary
Aniket Gupta, Ajijur Rahaman, Sukalyan Bhadra
Summary: Enzymatic reactions in Nature have exceptional stereoselection due to ordered transition states. Inspired by this, synthetic chemists have designed bifunctional ligands that activate carbonyl substrates via organocatalysis, accelerating the rate and facilitating stereoselectivity of bond formation. This review provides an overview of recent developments in this area.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Engineering, Chemical
Yasin Orooji, Zahra Nezafat, Mahmoud Nasrollahzadeh, Nasrin Shafiei, Morteza Afsari, Khatereh Pakzad, Amir Razmjou
Summary: The demand for lithium has increased significantly in the past decade due to its usage as a mainstream battery for electric vehicles and electronic devices. Lithium ion-sieve technology (LIS) has emerged as a promising method for extracting lithium from various sources, offering advantages such as low energy consumption, high uptake capacity, environmental friendliness, and superior lithium selectivity. This review paper critically examines recent developments in lithium extraction and recovery using LIS adsorbents and membranes from aqueous solutions, and highlights the stability challenges encountered with LIS adsorbents.
Article
Chemistry, Physical
Zhaopeng Qiao, Xiaobo Li, Yongsheng Lv, Yupeng Xie, Yaocheng Hu, Jie Wang, Haipeng Li, Sheng Wang
Summary: It has been found that depositing a thin titanium coating on lithium target can effectively isolate lithium from air and stabilize its chemical state, with negligible effects on neutron yield.
Article
Neurosciences
Jonathan Janssens, Bart Hermans, Marc Vandermeeren, Erio Barale-Thomas, Marianne Borgers, Roland Willems, Greet Meulders, Cindy Wintmolders, Dries Van den Bulck, Astrid Bottelbergs, Luc Ver Donck, Peter Larsen, Dieder Moechars, Wilson Edwards, Marc Mercken, Bianca Van Broeck
Summary: The imbalance between production and clearance of Aβ peptides is a crucial step in AD pathogenesis, making Aβ a promising therapeutic target. Research has shown that a high-affinity antibody targeting Aβ peptides with a pyroglutamate residue at amino acid position 3 can significantly reduce amyloid burden in mouse brains. Furthermore, combining this antibody treatment with chronic BACE1 inhibitor treatment leads to significant clearance of pre-existing amyloid deposits in the brain without inducing microhemorrhages or other histopathological findings.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Nanoscience & Nanotechnology
Huaze Wu, Takeshi Ueno, Kosuke Nozaki, Huichuan Xu, Yuki Nakano, Peng Chen, Noriyuki Wakabayashi
Summary: This study utilized anodization as a novel approach to immobilize lithium ions on a titanium surface and evaluated the changes in surface characteristics. The results showed that the surface charge characteristics were enhanced on the 3V-anodized surface, leading to increased adsorption of extracellular matrix proteins and improved attachment of osteoblast cells. This study suggests that anodization could be an effective method to promote osseointegration by modifying the surface charge characteristics and allowing for enhanced biological adhesion.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Inorganic & Nuclear
Sopida Thavornpradit, Thomas J. Malinski, David E. Bergbreiter
Summary: Poly(alpha-olefin)s (PAOs) can be used as alternative solvents and solvent systems for storage and reactions of reactive organometallics. They can substitute for conventional alkanes and offer higher safety.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
