期刊
TETRAHEDRON
卷 64, 期 52, 页码 11852-11859出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.08.111
关键词
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资金
- Fonds der Chemischen Industrie
- Novartis Pharma AG
The paper describes stereoselective radical aryl migration reactions from sulfur in sulfonates to aryl radicals for the synthesis of axially chiral biaryls. A chirality center in secondary benzylic sulfonates is used to diastereoselectively (atroposelectively) install a stereogenic axis via a 1,5 aryl migration reaction. Atroposelectivity has not been investigated in stereoselective radical chemistry before. Good yields (53-82%) but low selectivities (Lip to 2 to 1) were obtained. (C) 2008 Elsevier Ltd. All rights reserved.
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