An efficient route to dimeric porphyrin - RGD peptide conjugates via olefin metathesis

We report the efficient use of cross-metathesis for the solid-phase synthesis of a porphyrin dimer containing as a spacer a pentapeptide moiety with RGD sequence. Such compound appears as a promising candidate for application in PDT. (c) 2007 Elsevier Ltd. All rights reserved.