期刊
TETRAHEDRON
卷 64, 期 4, 页码 645-651出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.11.009
关键词
heterocycles; imidazoles; nitrites; cyclization
A simple, convenient and high-yielding one-pot method for the synthesis of 2-heterocycle-substituted imidazoles from the corresponding nitriles has been developed. The procedure is easily scaleable and the workup does not involve chromatography. This synthesis is also applicable to the preparation of imidazoles with electron-poor aryl substituents. (C) 2007 Elsevier Ltd. All rights reserved.
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