期刊
TETRAHEDRON
卷 64, 期 33, 页码 7745-7758出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.06.014
关键词
radical cyclisation; homolytic aromatic substitution; Bu3SnH; imidazole; pyrrole; pyrazole
Alkyl radicals have been cyclised onto pyrroles, imidazoles and pyrazoles, and acyl radicals cyclised onto pyrroles, using Bu3SnH-, (TMS)(3)SiH- and Bu3GeH-mediated aromatic homolytic substitution for the synthesis of bicyclic N-heterocycles. The reactions yield intermediate pi-radicals that lose hydrogen in the rearomatisation step of the aromatic homolytic substitution. Mechanistic studies of these rear-omatisation steps indicate aromatic homolytic substitution in which the initiator or breakdown products from the inhibitor are responsible for the H-abstraction step. (C) 2008 Elsevier Ltd. All rights reserved.
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