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Total synthesis of artochamins F, H, I, and J through cascade reactions

TETRAHEDRON (2008)

期刊

TETRAHEDRON

卷 64, 期 21, 页码 4736-4757

出版社

PERGAMON-ELSEVIER SCIENCE LTD

DOI: 10.1016/j.tet.2008.02.108

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Chemistry, Organic

资金

NCI NIH HHS [R01 CA100101, R01 CA100101-02, R01 CA100101-01A3, R01 CA100101-03] Funding Source: Medline

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Reagent

摘要

A concise and efficient cascade-based total synthesis of artochamins F, H, I, and J is described. The potential biogenetic connection between artochamin F, or a derivative thereof, and artochamins H, I, and J, through an unusual formal [2+2] cycloaddition process, was shown to be feasible. An alternative mechanism for this transformation is also proposed. (C) 2008 Elsevier Ltd. All rights reserved.

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