Article
Electrochemistry
Hiroyuki Fujimoto, Miwa Murakami, Toshiro Yamanaka, Keiji Shimoda, Hisao Kiuchi, Zempachi Ogumi, Takeshi Abe
Summary: The recharge and discharge mechanism of graphite electrodes is still unclear, and the research team used various technologies for real-time analysis, proposed a synchronized real-time analysis method, and studied the details of the intercalation mechanism.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Tamas Lazar, Elizabeth Martinez-Perez, Federica Quaglia, Andras Hatos, Lucia B. Chemes, Javier A. Iserte, Nicolas A. Mendez, Nicolas A. Garrone, Tadeo E. Saldano, Julia Marchetti, Ana Julia Velez Rueda, Pau Bernado, Martin Blackledge, Tiago N. Cordeiro, Eric Fagerberg, Julie D. Forman-Kay, Maria S. Fornasari, Toby J. Gibson, Gregory-Neal W. Gomes, Claudiu C. Gradinaru, Teresa Head-Gordon, Malene Ringkjobing Jensen, Edward A. Lemke, Sonia Longhi, Cristina Marino-Buslje, Giovanni Minervini, Tanja Mittag, Alexander Miguel Monzon, Rohit Pappu, Gustavo Parisi, Sylvie Ricard-Blum, Kiersten M. Ruff, Edoardo Salladini, Marie Skepo, Dmitri Svergun, Sylvain D. Vallet, Mihaly Varadi, Peter Tompa, Silvio C. E. Tosatto, Damiano Piovesan
Summary: The Protein Ensemble Database (PED) has been significantly updated to version 4.0, with cutting-edge technology and an increased amount of data. The database now includes a renewed graphical interface, interactive feature viewer, and high-quality data guaranteed by a new submission process. Additionally, a new search engine allows users to build advanced queries and search all entry fields.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Zhao Li, Zhiguo Ren, Yuanxin Zhao, Shuaijin Wu, Yingying Yao, Xiaochuan Ren, Daming Zhu, Xiaolong Li, Jianxin Zou
Summary: This study attempted to synthesize a spinel manganese-cobalt oxide using a hydrothermal method, but the inconsistent atomic ratio and presence of two phases in the synthesized sample resulted in failure.
Article
Chemistry, Physical
Nefise Ozcelik, Tuncay Tunc, Raziye Catak Celik, Mahmut Erzengin, Haci Ozisik
Summary: A newly synthesized hydrazone derivative was characterized using various methods including XRD for crystal structure determination and antioxidant activity testing. The results showed potential radical scavenging ability of the synthesized compound.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Jakob Lebon, Alexandros Mortis, Caecilia Maichle-Moessmer, Manfred Manssen, Peter Sirsch, Reiner Anwander
Summary: Commercially available stock solutions of organolithium reagents are widely used in organic and organometallic chemistry. However, these solutions are often contaminated with lithium halide salts, which can complicate synthesis and purification processes. In this study, chloride-free methyllithium was successfully isolated using K[N(SiMe3)(2)] as a halide-trapping reagent. The influence of different levels of LiCl contamination on Li-7-NMR chemical shift was examined and quantified. The structural parameters of a new chloride-free monomeric methyllithium complex [(Me(3)TACN)LiCH3], ligated by an azacrown ether, were assessed by comparison with a halide-contaminated variant and monomeric lithium chloride [(Me(3)TACN)LiCl], demonstrating the effect of halide impurities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Jarn E. Muenzer, Gregoire H. R. Sieg, Robert Vehlies, Patrick A. Fuzon, Xiulan Xie, Bernhard Neumueller, Istemi Kuzu
Summary: The reactions of carbodiphosphorane (CDPR) ligands with group 1 and Fe(II) bis(trimethylsilyl)amides produce unique CDP-stabilized ion pairs. X-ray diffraction analysis reveals that the cationic group 1 center is coordinated by two CDPR ligands. The influence of ligand substituents on the resulting architecture of the complexes was investigated using different CDP ligands.
Review
Chemistry, Inorganic & Nuclear
Maria del Mar Conejo, Antonio Pastor, Francisco Montilla, Agustin Galindo
Summary: This review focuses on the chemistry of transition metal compounds with phosphorus atom ligands, discussing the classification of phosphide complexes, coordination modes, structural analysis, and the use of P-31 NMR spectroscopy for characterization. The field continues to be of interest with new examples of complexes appearing in literature.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Astronomy & Astrophysics
Martino Marelli, Silvano Molendi, Mariachiara Rossetti, Fabio Gastaldello, David Salvetti, Andrea De Luca, Iacopo Bartalucci, Patrick Kuehl, Paolo Esposito, Simona Ghizzardi, Andrea Tiengo
Summary: The study focused on the EPIC/pn camera background, revealing a significant contribution from cosmic-ray interactions to the non-concentrated background. A constant component unaffected by the solar cycle was identified as a major source of the non-concentrated background. The findings provide important insights for future X-ray missions and suggest the potential impact of a high-energy particle monitor on improving background reproducibility in experiments.
ASTROPHYSICAL JOURNAL
(2021)
Article
Chemistry, Physical
Karthik Rajagopal, Saravanan Dhandayutham, Manivannan Nandhagopal, Mathivanan Narayanasamy
Summary: This research work successfully synthesized bis-benzimidazole derivatives using simple and eco-friendly reaction conditions and crystallization procedures. The structures of the compounds were determined using 1H NMR, 13C NMR, and mass spectroscopic techniques. Among these derivatives, compound 1c exhibited crystal nature as confirmed by single crystal X-ray study. The synthesized compounds were tested for antimicrobial activity against various human bacterial and fungal pathogens, and compound 1e demonstrated the best inhibitory effect with a minimum inhibitory concentration of 16 μg/mL against C. albicans. Molecular docking analysis further revealed that compound 1g had the best binding energy with fungal protein C. albicans.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Summaira Fayyaz, Farzana Shaheen, Saqib Ali, Samar Naseer, Scopelliti Rosario
Summary: The synthesis of five new antimicrobial organotin(IV) carbodithioates with different coordination geometries in solid and solution states showed significant activity against five different bacterial strains.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Sh. Yu. Khazhiev, M. A. Khusainov, R. A. Khalikov, V. A. Kataev, T. V. Tyumkina, E. S. Mescheryakova, L. M. Khalilov, V. V. Kuznetsov
Summary: The conformation of the molecule 5,5-bis(bromomethyl)-2-trichloromethyl-1,3-dioxane in the crystalline phase and in solution was analyzed using NMR H-1, C-13, and X-ray analysis data. It was found that the molecule adopts a chair conformation with an axial trichloromethyl group and an equatorial trichloromethyl group. The conformational transformations and transition states for the molecule and a cluster with five chloroform molecules were determined using DFT approximation PBE/3 xi.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
Satyendra Kumar, Malathy Selvachandran, Kuppuswamy Arumugam, Mohamed C. Shaw, Che Wu, Michael Maurer, Xiaodong Zhang, Stephen Sproules, Joel T. Mague, James P. Donahue
Summary: Open-ended, singly metalated dithiolene complexes were prepared using different methods, and their structures were characterized by X-ray crystallography.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Karolina Stryjska, Izabela Korona-Glowniak, Lilianna Checinska, Joachim Kusz, Justyn Ochocki
Summary: The synthesis of two novel silver(I) complexes of miconazole with new counter ions was conducted, showing significant antimicrobial activity against Gram-positive bacteria and yeasts, surpassing silver sulfadiazine and silver salts. The complex containing the nitrate counter ion exhibited the highest antimicrobial activity, while all silver(I) complexes of miconazole demonstrated better inhibition of yeast growth compared to silver sulfadiazine, silver salts, and miconazole. Additionally, the synthesized complexes showed good or moderate activity against Gram-negative bacteria when compared to the free ligand.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Inorganic & Nuclear
Isabelle Gerz, Sergio Augusto Venturinelli Jannuzzi, Knut T. Hylland, Chiara Negri, David S. Wragg, Sigurd Oien-Odegaard, Mats Tilset, Unni Olsbye, Serena DeBeer, Mohamed Amedjkouh
Summary: A series of Cu(I) complexes with bidentate or tetradentate Schiff base ligands containing 1-H-imidazole or pyridine moieties were synthesized and studied using NMR and X-ray spectroscopic techniques. The nature of the heterocycle in the ligands strongly affected the coordination shifts of N-15(imine) in the complexes, which correlated well with the Cu-N-imine bond lengths from single-crystal X-ray diffraction measurements. Variable-temperature NMR experiments revealed a temperature-dependent interconversion in one complex, while Cu K-edge XAS and VtC XES studies suggested the formation of polynuclear oligomers in solid state for complexes with tetradentate imidazole ligands. Incorporation of a Cu(II) analogue into a MOF resulted in discrete, mononuclear complexes in the solid state.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Ezzat Khan
Summary: Alkenylsilanes with chlorosilyl and boryl groups attached to a carbon atom were synthesized through hydroboration of alkynylsilanes. They reacted with N-trimethylsilylpyrazole and N-2-(trimethylsilylamino)pyridine to form Si-N bonds, resulting in heterocycles containing Si, N, and B atoms. Treatment of a dichlorosilane with trimethylsilylpyrazole yielded a bis(pyrazolyl)silane.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Marialuisa Formato, Giovanna Cimmino, Nabila Brahmi-Chendouh, Simona Piccolella, Severina Pacifico
Summary: There is a growing interest in specialized metabolites as an alternative for fortification strategies in feed and as a means to combat disorders that can impact human nutrition. However, conflicting results emerge from recent studies. It is necessary to further investigate the role of specific compounds or mixtures commonly used for research purposes in ruminant feeding.
Article
Biochemistry & Molecular Biology
Marialuisa Formato, Alessandro Vastolo, Simona Piccolella, Serena Calabro, Monica Isabella Cutrignelli, Christian Zidorn, Severina Pacifico
Summary: Chestnut leaves are a valuable byproduct rich in bioactive compounds that can be used as animal feed ingredients. Through extraction and fractionation, the polyphenolic constituents in chestnut leaves were effectively separated and showed antioxidant and methane-inhibiting activities. These findings demonstrate the potential of chestnut leaves as a sustainable and novel feed ingredient.
Article
Biochemistry & Molecular Biology
Marika Fiorentino, Simona Piccolella, Claudia Gravina, Adriano Stinca, Assunta Esposito, Michelina Catauro, Severina Pacifico
Summary: Wild edible plants are now used as dietary supplements to enhance local dishes and develop healthy nutraceutical products. Recent investigation focused on the metabolic profile of Calendula arvensis and found that the flower florets contain abundant flavonol glycosides and triterpene saponins. A freeze-drying encapsulation technique was used to preserve these compounds and their biocompatibility, as well as the effects of in vitro digestion on compound preservation, were evaluated.
Article
Biochemistry & Molecular Biology
Marialuisa Formato, Alessandro Vastolo, Simona Piccolella, Serena Calabro, Monica Isabella Cutrignelli, Christian Zidorn, Severina Pacifico
Summary: The residual material from the genus Quercus can be used in pharmaceutical, nutraceutical, or cosmeceutical sector, as well as benefit livestock feeding. The leaf extract of Quercus robur L. from Northern Germany contains a polyphenol fraction that has antioxidant and modulation properties.
Article
Biochemistry & Molecular Biology
Claudia Gravina, Marialuisa Formato, Simona Piccolella, Marika Fiorentino, Adriano Stinca, Severina Pacifico, Assunta Esposito
Summary: Lavandula austroapennina is a newly described species endemic to the southern Apennines in Italy. It has a long ethnobotanical tradition and its organs have been found to contain rich (poly)phenols which have potential antioxidant and wound healing properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Michelina Catauro, Antonio D'Angelo, Veronica Viola, Giovanna Cimmino, Severina Pacifico
Summary: Organic-inorganic hybrid materials were synthesized using a sol-gel route, incorporating silicon alkoxide, low molecular weight polycaprolactone, and caffetannic acid. The hybrids were characterized using scanning Fourier-transform infrared spectroscopy and scanning electron microscopy, and their antiradical capacity, as well as effects on bacterial growth, were evaluated. The formation of a biologically active hydroxyapatite layer on the surface of the hybrids was observed. Biocompatibility with NIH-3T3 fibroblast cells was demonstrated, but cytotoxicity towards colon, prostate, and brain tumor cell lines was also observed. These findings provide valuable insights into the potential applications of the synthesized hybrids in the medical field.
Article
Green & Sustainable Science & Technology
Eleonora Grilli, Renata Concetta Vigliotti, Antonio Fiorentino, Monica Scognamiglio, Luigi Rossetti, Thiago Assis Rodrigues Nogueira, Arun Dilipkumar Jani, Cassio Hamilton Abreu, Ludmila Roder, Antonio Ganga, Gian Franco Capra
Summary: Soil rebuilding at abandoned quarries can be achieved using reconstructed Technosols. Organic amendment techniques showed better soil physical-chemical properties, plant growth, and overall agronomic performances compared to other treatments. These findings suggest the potential of these pedotechniques in facilitating environmental reclamation in degraded Mediterranean areas.
Article
Biochemistry & Molecular Biology
Luigi Mandrich, Simona Piccolella, Antonia Valeria Esposito, Silvio Costa, Vincenzo Mercadante, Severina Pacifico, Emilia Caputo
Summary: This study investigated the anti-proliferation potential of extracts from carrot, Calendula officinalis flower, and Aloe vera on breast cancer vs. epithelial cell lines. The extracts were able to specifically inhibit the proliferation of breast cancer cell lines, and the different lipid compounds in the extracts may be associated with their observed different anti-proliferative properties.
Review
Biochemistry & Molecular Biology
Maria Teresa Gentile, Iolanda Camerino, Loredana Ciarmiello, Pasqualina Woodrow, Lidia Muscariello, Ida De Chiara, Severina Pacifico
Summary: The brain, which is made up of billions of neurons, controls all bodily functions and is a complex network of interacting dynamical systems. Neurodegenerative disorders can occur when the functions of neurons are impaired, and there is an urgent need to find new strategies for prevention. Polyphenols, a diverse group of plant compounds, have the potential to counteract chronic degenerative disease in the central nervous system. They have antioxidant activities, can inhibit acetylcholinesterase, and protect against neurodegenerative diseases such as Alzheimer's by preventing protein aggregation and abnormal phosphorylation. Furthermore, polyphenols' role as natural chelators and their influence on the gut-brain axis through the microbiota provide new opportunities for studying molecular mechanisms and developing novel strategies for neurological diseases.
Article
Plant Sciences
Francesca Guzzo, Elisabetta Buommino, Leslie Landrum, Rosita Russo, Francesca Lembo, Antonio Fiorentino, Brigida D'Abrosca
Summary: Myrcianthes cisplatensis is a common tree with medicinal properties, including diuretic, febrifuge, and treatment for lung and bronchial diseases. The compounds isolated from this tree showed antimicrobial activity, particularly against Staphylococcus aureus.
Article
Chemistry, Medicinal
Annalisa Ambrosino, Annalisa Chianese, Carla Zannella, Simona Piccolella, Severina Pacifico, Rosa Giugliano, Gianluigi Franci, Antonino De Natale, Antonino Pollio, Gabriele Pinto, Anna De Filippis, Massimiliano Galdiero
Summary: In recent decades, there has been a significant increase in interest in bioactive compounds derived from natural sources. Aquatic or terrestrial organisms have the ability to produce secondary metabolites with various biological properties, such as anticancer, antioxidant, anti-inflammatory, and antimicrobial activities. This study focused on the extremophilic microalga Galdieria sulphuraria as a potential producer of bioactive compounds with antiviral activity. The algal extract showed strong antiviral activity against enveloped viruses, particularly HSV-2 and HCoV-229E, while no activity was observed against the non-enveloped poliovirus. Chemical analysis revealed the presence of primary fatty acid amides (PFAA) in the extract. These findings suggest the potential role of the algal extract as an antiviral agent and warrant further purification and exploration.
Review
Biochemistry & Molecular Biology
Barbara Pizzicato, Severina Pacifico, Diana Cayuela, Gabriela Mijas, Marta Riba-Moliner
Summary: The dyeing and finishing step is a significant hotspot in the textile supply chain due to the high water, energy, and chemical requirements of the wet processing stages. Researchers are increasingly focusing on natural dyes as more sustainable alternatives to synthetic ones in order to address environmental concerns. This review provides an overview of natural dyes and their differences compared to synthetic dyes, and summarizes recent research in the field, particularly in the areas of extraction techniques, substrate preparation, mordanting process, and dyeing process. Promising new technologies and techniques have been developed to enhance the performance and sustainability of natural dyeing processes; however, challenges such as poor fastness properties, low affinity with textile substrates, difficulties in shade reproducibility, and cost-effectiveness considerations hinder the widespread adoption of natural dyes in the industry, necessitating further research.
Article
Food Science & Technology
Elena Cioffi, Lara Comune, Simona Piccolella, Mario Buono, Severina Pacifico
Summary: In recent years, the revaluation of end-of-life products has become more widespread as part of sustainable development policies. This study focused on the valorization of wine sector wastes, specifically the leaves of Vitis vinifera L. cv. Aglianico from the Campania Region in Italy. By using deep eutectic solvents as a greener alternative to organic solvents and employing ultrasound-assisted maceration and LC-MS tools, the study revealed a six-month quantitative variation of flavonol derivatives, such as quercetin 3-O-glucuronide, based on collection time and leaf height on the grapevine. The findings emphasized the importance of considering abiotic factors, like sunlight exposure, for the complete recovery of these compounds.
Article
Chemistry, Medicinal
Cinzia Sanna, Brigida D'Abrosca, Antonio Fiorentino, Federica Giammarino, Ilaria Vicenti, Angela Corona, Alessia Caredda, Enzo Tramontano, Francesca Esposito
Summary: This study investigated the effect of Plagius flosculosus (L.) Alavi & Heywood, a Sardinian-Corsican endemic plant, on HIV-1 integrase (IN) activity for the first time. Three spiroketals compounds (SPK1, SPK2, and SPK3) were isolated and characterized from the leaves chloroform extract, which belong to a group of naturally occurring metabolites with interesting biological properties. The results showed that all three compounds inhibited HIV-1 IN and RNase H activity, with SPK3 being the most active, suggesting a potential allosteric mechanism of action.
Article
Biochemistry & Molecular Biology
Armando Di Palo, Chiara Siniscalchi, Giuseppina Crescente, Ilenia De Leo, Antonio Fiorentino, Severina Pacifico, Aniello Russo, Nicoletta Potenza
Summary: This study examined the impact of three metabolites isolated from hemp seeds on the expression levels of microRNAs in human neural cells. The results showed significant changes in 31 microRNAs, some of which are implicated in neural functions and are known to be involved in Alzheimer's disease. These findings provide new insights into the mechanism of action of hemp seed metabolites and their potential effects on the central nervous system.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
