Article
Chemistry, Organic
Gang Liu, Congcong Yin, Xuanliang Yang, Anqi Li, Minyan Wang, Xumu Zhang, Xiu-Qin Dong
Summary: A highly chemo- and enantioselective hydrogenation method for beta-sulfonyl-alpha,beta-unsaturated ketones was successfully developed, producing a variety of enantioenriched gamma-ketosulfones in good to high yields with excellent selectivities. Gram-scale asymmetric hydrogenation was carried out smoothly with high yields and selectivities. Preliminary DFT computations provided a reasonable explanation for the observed high chemoselectivity and enantioselectivity.
Article
Chemistry, Organic
Vincenzo Marsicano, Antonio Arcadi, Marco Chiarini, Giancarlo Fabrizi, Antonella Goggiamani, Antonia Iazzetti
Summary: The divergent domino condensation/biannulation reaction of beta-(2-aminophenyl) alpha,beta-ynones with 1,3-dicarbonyls to construct a polycyclic 4H-pyrano[3,4-c]quinoline core was developed, catalyzed by p-TsOH center dot H2O. The reaction proceeds in ethanol with good to excellent yields, providing a simple and effective method for the synthesis of functionalized 4H-pyrano[3,4-c]quinolinones. Further elaboration with an excess of 20% NH4OH in EtOH at 50 degrees C helps achieve the synthesis of the perlodinine analogues benzo[c][2,7]naphthyridin-4(3H)-one derivatives in high yields.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Applied
Rikuo Hayashi, Kaori Ando, Taro Udagawa, Masahiro Sai
Summary: This study presents a method for synthesizing diverse beta-functionalized ketones from readily available 1-arylallylic alcohols in the presence of (trimethylsilyl)methylpotassium (TMSCH2K). The reaction proceeds via the formation of a highly nucleophilic dipotassio alpha,beta-dianion, which serves as a metal homoenolate equivalent and allows the one-pot synthesis of alpha,beta-difunctionalized ketones.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Zhichao Wang, Shoko Yamazaki, Yuji Mikata, Miho Oba, Hiroshi Takashima, Tsumoru Morimoto, Akiya Ogawa
Summary: Intramolecular cycloaddition reactions of α-bromostyr-ene-functionalized amides have been investigated, resulting in the formation of 1,4-dihydronaphthalenes and naphthalene derivatives under suitable reaction conditions. The mechanisms of these reactions may involve the intervention of molecular oxygen and subsequent radical reactions.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Yu-Song Ran, Bo Jiang, Yun-Tao Shen, Tai-Gang Fan, Wei Jiang, Cui Zhang, Ya-Min Li
Summary: A visible-light-promoted cascade cyclization reaction has been developed for the synthesis of tetrahydrobenzo[mn]cyclopenta[b]acridines using 3-ethynyl-[1,1'-biphenyl]-2-carbonitriles and unsaturated alpha-bromocarbonyls. This reaction involves the formation of three C(sp(3))-C(sp(2)) bonds, one C(sp(2))-N bond, and three cycles in a single step, through the addition of a C-centered radical to the carbon-carbon triple bond and subsequent radical cyclizations. The reaction conditions are mild, and the reaction shows a wide substrate scope and high efficiency in bond formation.
Article
Chemistry, Organic
Yueqiang Liu, Sheng Zhang, Yang Li, Xiaoqiang Yu, Xiujuan Feng, Yoshinori Yamamoto, Ming Bao
Summary: This paper describes a new strategy for the in situ generation of vinyl cation intermediates from alpha-diazocarbonyl compounds, which has been successfully applied in the synthesis of various organic compounds.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Multidisciplinary
Sunewang R. Wang
Summary: Due to the unique chemical structure and photophysical properties, azulene derivatives hold great potential for various technical applications, such as molecular switching, sensors, solar cells, and biological activities. Apart from functionalizing existing azulene cores, direct construction of azulenes through condensation with odd-membered carbocycles is another classical method. Unconventional cyclization reactions involving alkynes can also lead to the formation of azulene, pseudoazulene, or azulenone skeletons. This mini review provides a classification of the interesting and practical cyclization reactions based on the function of alkynes, with the aim of attracting attention and promoting the development of nonalternant cyclization reactions of alkynes.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Review
Chemistry, Applied
Ya-Feng Si, Qi-Yan Lv, Bing Yu
Summary: This review summarizes and classifies three catalytic ways of radical cascade cyclization of beta,gamma-unsaturated hydrazones/oximes: transition-metal-catalyzed systems, transition-metal-free systems, and photo-/electrocatalytic systems. Through these methods, various functional groups are installed on the pyrazoline and isoxazoline skeletons to enrich the small organic molecule library.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Zhi-Min Yan, Lin Qi, Tong-Yang Cao, Jia-Li Liu, Hui-Jie Du, Yi-Chen Dong, Wei Li, Li-Jing Wang
Summary: An efficient aminofluorosulfonylation strategy was developed for the synthesis of pyrazoline-functionalized aliphatic sulfonylfluorides using beta,gamma-unsaturated hydrazones, sulfur dioxide, and NFSI as starting materials. The sulfonyl fluoride products could be transformed into sulfonate esters and amides through the SuFEx click reactions. The reaction operates through a radical cyclization/SO2 insertion/fluorination cascade process.
Article
Chemistry, Organic
Zhichao Wang, Shoko Yamazaki, Tsumoru Morimoto, Hiroshi Takashima, Ayane Nakaoku, Makoto Shimizu, Akiya Ogawa
Summary: This study investigated intramolecular cyclization reactions of arylpropargyl amides of electron-deficient alpha, beta-alkenyl carboxylates, such as fumarates and ethenetricarboxylates. The reactions yielded benz[f]isoindoline derivatives when fumaramides were reacted with a base, Et3N or DBU, in xylenes under air. Aroyl-substituted pyrrolidine derivatives were obtained as major products when amides of fumarate and ethenetricarboxylate were heated in DMSO. The reaction mechanisms were discussed using density functional theory (DFT) calculations.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Yunhe Lv, Weiya Pu, Xueli Zhu, Chen Chen, Shanshan Wang
Summary: An efficient method has been developed for the synthesis of (E)-beta-monofluoroalkyl-beta, gamma-unsaturated esters or ketones through a copper-catalyzed three-component reaction, featuring a broad substrate scope, inexpensive and easily available catalytic system, and excellent selectivity with good yields. The mechanism of the reaction involving tandem Cu-catalyzed cross-coupling and nucleophilic addition of allenes has been investigated.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Xiaoping Hu, Xin Xie, Yi Gan, Gaonan Wang, Yuanhong Liu
Summary: A highly regioselective nickel/Lewis acid catalyzed amination/cyclization reaction of ynamide-nitriles with amines involving beta-addition has been developed, providing an efficient route for the synthesis of 3-aminoindoles and 4-aminoisoquinoline derivatives. The Ts-group on the ynamide serves as a directing group, leading to the formation of alkenyl nickel species with high regioselectivity.
Article
Chemistry, Organic
Suraj, K. C. Kumara Swamy
Summary: Functionalized azetidines, 2,3-dihydrofurans, or the unorthodox dioxa-3-azabicyclonone-4-ene motifs can be synthesized through transition metal-free reactions. The reaction products depend on the reaction conditions used. The study also reveals the structure of the intermediate involved in the reaction. Additionally, isomeric diazocanes with separation and crystallization properties were successfully synthesized.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Shiqi Jia, Yu Chang, Yuhong Tian, Hui Mao, Wenling Qin, Pengfei Wang, Hailong Yan
Summary: An organocatalytic approach using VQM intermediates was employed to introduce various alcohols into the carbonyl of alpha,beta-unsaturated ketones, followed by dearomatization to yield stereo-defined cyclic ethers via a cascade process. This strategy provides efficient access to the unexplored chiral cyclic ether chemospace.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Guihua Nie, Tingting Li
Summary: This article summarizes the facile syntheses of multicyclic molecules through multi-step cascade reactions with N-Heterocyclic carbene (NHC)-catalyzed LUMO activation strategies. The reaction mechanisms involved in these cascade catalytic transformations are also provided and discussed. The review article is arranged according to the reaction starting materials that are used for the NHC-catalytic activation processes.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Ghulam Abbas Shah, Maqsood Sadiq, Zahid Iqbal, Noman Shakoor, Muhammad Shahid, Azhar Mehmood Aulakh, Kamusiime Arthur, Nadeem Khan, Iqbal M. I. Ismail, Muhammad Imtiaz Rashid
Summary: The co-inoculation of Bradyrhizobium sp. and phosphorus-solubilizing bacteria (Pseudomonas sp.) can improve the growth, yield, and nitrogen and phosphorus utilization of mungbean crops from chemical fertilizers in nutrient-deficient soils.
JOURNAL OF PLANT NUTRITION
(2023)
Article
Physics, Condensed Matter
Rabia Nazir, Junaid Yaqoob, Muhammad Usman Khan, Mazhar Amjad Gilani, Riaz Hussain, Muhammad Usman Alvi, Muhammad Rashid, Mohammed A. Assiri, Muhammad Imran
Summary: This study attempted to design alkali metal-doped functionalized complexes and investigate their geometric, thermodynamic, electronic and NLO properties using computational methods. The results showed that these complexes exhibited excellent thermodynamic stability and a reduced HOMO-LUMO energy gap, and were transparent in the UV region. Additionally, the calculations revealed the charge transfer, participation of different fragments, and type of interaction in the complexes.
PHYSICA B-CONDENSED MATTER
(2022)
Article
Agriculture, Dairy & Animal Science
Muhammad Adeel Maqsood, Ehsaan Ullah Khan, Shafqat Nawaz Qaisrani, Muhammad Afzal Rashid, Muhammad Shabir Shaheen, Azhar Nazir, Hammad Talib, Sohail Ahmad
Summary: This study evaluated the effects of reducing CP levels and supplementing with exogenous protease on broiler chickens. The results showed that a reduction of 20% CP balanced with a lysine ratio of 110% and supplemented with exogenous protease improved growth performance, intestinal health, and carcass traits.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2022)
Article
Cardiac & Cardiovascular Systems
Nicholas Weight, Saadiq Moledina, Giuseppe Biondi Zoccai, Sarah Zaman, Triston Smith, Jolanta Siller-Matula, Mohamed Dafaalla, Muhammad Rashid, James Nolan, Mamas A. Mamas
Summary: Little is known about the care outcomes and processes of patients with non-ST-segment myocardial infarction (NSTEMI) who have polyvascular disease. A study analyzed 287,279 NSTEMI patients and found that those with polyvascular disease had higher rates of major adverse cardiovascular events and in-hospital mortality. Patients without a history of vascular disease were less likely to receive statins or ACE inhibitors/ARBs, but more likely to receive dual antiplatelet therapy.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Business, Finance
Muhammad Rashid, Naimat U. Khan, Umair Riaz, Bruce Burton
Summary: This study aims to investigate auditors' perspectives on financial shenanigans in Pakistan. The findings indicate that financial malpractice is common, taking various forms, and characterized by audacity and shamelessness. The study also highlights the absence of institutional pillars and motivations for legitimizing such behavior. Understanding the embedded practices of fraudulent financial reporting is crucial for making informed investment decisions in Pakistani firms.
JOURNAL OF ACCOUNTING IN EMERGING ECONOMIES
(2023)
Article
Oncology
Muhammad Usman Rashid, Noor Muhammad, Umara Shehzad, Faiz Ali Khan, Asif Loya, Ute Hamann
Summary: The FANCM gene is potentially associated with breast/ovarian cancer susceptibility in European populations. This study examined the contribution of FANCM germline variants to hereditary breast and/or ovarian cancer in Pakistani patients. The findings suggest a limited role of FANCM variants in hereditary breast/ovarian cancer in Pakistan, which requires confirmation in larger studies.
Article
Engineering, Geological
Muhammad Rashid, Rajesh P. Dhakal, Timothy J. Sullivan, Trevor Z. Yeow
Summary: This study conducted shake table tests to investigate the impact of earthquakes on fire sprinkler systems. The results showed that bracing segments other than the distribution pipe can modify the system's dynamic characteristics and significantly increase seismic demands if the system resonates with the floor excitation. Recommendations are provided for improving the relevant standard to estimate seismic demands more reliably.
BULLETIN OF THE NEW ZEALAND SOCIETY FOR EARTHQUAKE ENGINEERING
(2022)
Article
Energy & Fuels
Arshid Mahmood Ali, Muhammad Shahbaz, Khurram Shahzad, Muddasser Inayat, Salman Naqvi, Abdulrahim Ahmad Al-Zahrani, Muhammad Imtiaz Rashid, Mohammad Rehan, Aishah Binti Mahpudz
Summary: Date palm waste (DPW) is a valuable waste product in the Middle East that can be utilized to generate sustainable energy. This study developed an integrated system model to predict gas composition and power generation from DPW. The results show that DPW can be converted into syngas, with varying gas composition and power generation depending on operating variables. This research highlights the potential of DPW for renewable fuel and electricity generation, offering an environmentally friendly solution for waste disposal.
Article
Parasitology
Muhammad Rizwan, Shahzad Ali, Arshad Javid, Muhammad Imran Rashid
Summary: This study investigated the prevalence of Toxoplasma gondii infection in rodents in the Sahiwal division of Pakistan, and found a higher infection rate in Rattus norvegicus compared to Rattus rattus. All risk factors were not statistically significant.
PARASITOLOGY RESEARCH
(2023)
Article
Environmental Sciences
Nadeem Ali, Muhammad Imtiaz Rashid, Nabil A. Alhakamy, Sultan Hassan Alamri, Syed Ali Musstjab Akber Shah Eqani
Summary: In this study, the levels of flame retardants and phthalates in indoor household dust during the COVID-19 lockdown period in Jeddah, Saudi Arabia, were analyzed. The results showed high concentrations of these chemicals, particularly DEHP. Saudi children were found to be exposed to DEHP at levels exceeding the reference dose, indicating a risk to their health. This study highlights the increased indoor pollution during the lockdown period and the potential health consequences.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Health Care Sciences & Services
Ramadugula Suhita, Izwath Begum, Muhammed Rashid, Viji Pulikkel Chandran, Sanjana Aditya Shastri, Raveena Kantamneni, Asha K. Rajan, Girish Thunga
Summary: Snakebites are a significant global health concern, with the highest prevalence observed in North America and the lowest in Africa. The most prevalent haemotoxicity is coagulopathy, while ptosis is the most common symptom of neurotoxicity.
EASTERN MEDITERRANEAN HEALTH JOURNAL
(2022)
Article
Veterinary Sciences
Sohrab Ahmad, Muhammad Shahbaz Yousaf, Sajid Khan Tahir, Muhammad Afzal Rashid, Khalid Abdul Majeed, Mahrukh Naseem, Mohsin Raza, Zafar Hayat, Abia Khalid, Hafsa Zaneb, Habib Rehman
Summary: This study investigated the effects of co-supplementation of beta-GOS and methionine on meat quality traits and muscle formation and degradation pathways in broilers. The results showed that beta-GOS supplementation reduced pH change rate, cooking loss, and muscle fiber diameter, while increasing muscle catalase level and fiber density. Methionine had regulatory effects on gene expression, downregulating MAFbx and MuRF1 genes and upregulating MyoD and M-CK genes.
PAKISTAN VETERINARY JOURNAL
(2023)
Article
Computer Science, Information Systems
Iftikhar Naseer, Tehreem Masood, Sheeraz Akram, Arfan Jaffar, Muhammad Rashid, Muhammad Amjad Iqbal
Summary: This article introduces the dangers and fatality of lung cancer, as well as the importance of pulmonary nodules in lung cancer detection. It proposes an automatic nodule detection method based on modified AlexNet architecture and Support Vector Machine (SVM) algorithm, and verifies its superior performance on the LUNA16 dataset through experimental analysis.
CMC-COMPUTERS MATERIALS & CONTINUA
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Sultan Daud Khan, Rafi Ullah, Mussadiq Abdul Rahim, Muhammad Rashid, Zulfiqar Ali, Mohib Ullah, Habib Ullah
Summary: COVID-19 has caused a global health crisis with millions of infections worldwide. This paper proposes an automated approach based on deep learning to analyze complex scenes and identify people wearing or not wearing face masks, showing high performance and outperforming other methods.
ARTIFICIAL INTELLIGENCE APPLICATIONS AND INNOVATIONS, AIAI 2022, PART I
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mahvash Zaman, Muhammad Rashid, Peter Ludman, Nick Curzen, Saadiq Moledina, Cindy Grines, Mamas Mamas
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
