Review
Environmental Sciences
Tomoya Takiguchi, Hoa Thi Vu, Yoshikazu Nishino
Summary: Bone metabolism is regulated by endocrine systems, and exposure to PCDD/Fs can have adverse effects on bones and teeth. Previous studies have shown that exposure to PCDD/Fs can affect odontogenesis and bone genesis, particularly enamel formation and palatine bone. It is also found that exposure to PCDD/Fs in milk can affect both teeth and bones, with reversible effects on bones. Furthermore, high concentrations of PCDD/Fs can adversely affect teeth even in adulthood, but exposure to PCDD/Fs may also induce osteogenesis and improve bone properties. Further human studies are needed to investigate the associations between PCDD/F concentrations and biological markers for teeth and bones.
Article
Environmental Sciences
O. J. Nostbakken, J. D. Rasinger, R. Hannisdal, M. Sanden, L. Froyland, A. Duinker, S. Frantzen, L. M. Dahl, A-K Lundebye, L. Madsen
Summary: This study conducted an analysis of the nutrients and harmful substances in seafood, finding that the levels of beneficial components and potentially harmful substances in oily seafood can meet the needs of human health, providing important data support for future risk-benefit assessments.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Sabrina Battisti, Paola Scaramozzino, Carlo Boselli, Fabio Busico, Sesto Berretta, Marcello Sala, Bruno Neri
Summary: This study reports the data of polychlorinated dibenzo-p-dioxins (PCDDs), -furans (PCDFs), and polychlorinated biphenyls dioxin-like (dl PCBs) measured in a total of 260 samples of the dairy supply chain collected over a period of 7 years (2011-2017) in the Latium region (Italy). The study found that sheep milk had the highest levels of pollutants, while buffalo milk had relatively lower levels. This study provides important reference values for background contamination of the dairy supply chain in the Latium region.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Crystallography
Allea Campbell, Ziad Alsudairy, Chaochao Dun, Fazli Akram, Kayla Smith-Petty, Abrianna Ambus, Danielle Bingham, Tandabany Dinadayalane, Conrad Ingram, Xinle Li
Summary: This study presents the first immobilization of palladium acetate onto a dioxin-linked covalent organic framework (Pd/COF-318) using a facile solution impregnation approach. Pd/COF-318 exhibits high activity and broad substrate scope for Suzuki-Miyaura coupling reactions, making it one of the most effective Pd/COF catalysts to date. It also demonstrates excellent recyclability and heterogeneity of the catalyst, highlighting the potential of dioxin-linked COFs as catalyst supports for organometallic catalysis.
Article
Multidisciplinary Sciences
Lara E. Zetzsche, Jessica A. Yazarians, Suman Chakrabarty, Meagan E. Hinze, Lauren A. M. Murray, April L. Lukowski, Leo A. Joyce, Alison R. H. Narayan
Summary: This study demonstrates the use of cytochrome P450 enzymes for biocatalytic cross-coupling reactions, enabling the formation of sterically hindered biaryl bonds through oxidative C-C bond formation. By engineering the substrate and atroposelectivity of the P450 enzyme, a highly efficient and selective process has been developed.
Article
Environmental Sciences
Ha-Hyun Lee, Sunggyu Lee, Jung Suk Lee, Hyo-Bang Moon
Summary: Limited studies have been conducted on polychlorinated naphthalenes (PCNs) in the coastal environment worldwide. Analytical methods were optimized for 18 PCN congeners in sediment, showing ubiquitous contamination in industrialized coastal regions of Korea. Industrial activities are primary sources of PCNs, with CNs 73 and 52 being predominant congeners in sediment samples.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Shubham Sharma, Anjani, Mobina Kouser, Monika Gupta
Summary: The development of a graphene-based nanocatalyst (Pd@NGO) with large surface area offers potential as an efficient tool for various organic transformations. Characterization techniques confirmed the mesoporous texture of the nanocatalyst and its successful doping with nitrogen. The nanocatalyst showed high efficiency in Suzuki coupling reaction, reduction of nitro compounds, and photodegradation of methyl orange.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
K. P. Rajappan Nair, Sven Herbers, Jens-Uwe Grabow, Ha Vinh Lam Nguyen
Summary: Rotational spectrum of 2-fluoro-4-chlorotoluene was studied using Fourier transform microwave spectroscopy, revealing fine torsional splittings and quadrupole coupling hyperfine splittings. Precise rotational and quadrupole coupling constants for Cl-35 and Cl-37 isotopologues were determined, supported by quantum chemical calculations and Bailey's semi-experimental method. Comparison with other halogen-substituted toluene derivatives was made in terms of quadrupole coupling tensor element and barrier to methyl internal rotation.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Jie Xu, Samantha Grosslight, Kyle A. Mack, Sierra C. Nguyen, Kyle Clagg, Ngiap-Kie Lim, Jacob C. Timmerman, Jeff Shen, Nicholas A. White, Lauren E. Sirois, Chong Han, Haiming Zhang, Matthew S. Sigman, Francis Gosselin
Summary: An efficient asymmetric synthesis of a potent KRAS G12C covalent inhibitor, GDC-6036, was reported. The synthesis involved a highly selective Negishi coupling and a series of reaction sequences, leading to the desired compound with a 40% overall yield from the starting materials.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Environmental Sciences
Saman Sana, Abdul Qadir, Neil P. Evans, Mehvish Mumtaz, Ambreena Javaid, Amjad Khan, Saif-Ur-Rehman Kashif, Habib Ur Rehman, Muhammad Zafar Hashmi
Summary: Punjab is the leading province in Pakistan for the production and consumption of bovine milk. This study found that high concentrations of PCBs were present in buffalo and cow milk, with PCB-156 being the most predominant congener. Daily intake levels of DL-PCBs and I-PCBs from the milk samples were below the acceptable limits for both adults and children.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Reproductive Biology
Sonia Alarcon, Javier Esteban, Robert Roos, Paivi Heikkinen, Ismael Sanchez-Perez, Annika Adamsson, Jorma Toppari, Antti Koskela, Mikko A. J. Finnila, Juha Tuukkanen, Maria Herlin, Gerd Hamscher, Heather A. Leslie, Merja Korkalainen, Krister Halldin, Dieter Schrenk, Helen Hakansson, Matti Viluksela
Summary: The study investigated the developmental toxicity of PCB 180 in offspring following in utero and lactational exposure, revealing that male offspring were more sensitive to increased liver weight, PROD induction, and decreased thyroxine concentrations, while female offspring were more sensitive to other effects. The MoE assessment indicated that the 95th percentile of current maternal PCB 180 concentrations did not exceed the estimated tolerable human lipid-based PCB 180 concentration.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Chemistry, Physical
Sanita B. Tailor, Mattia Manzotti, Gavin J. Smith, Sean A. Davis, Robin B. Bedford
Summary: The cobalt-catalyzed Suzuki biaryl cross-coupling reaction using alkoxide bases, with strict stoichiometric control and selection of the right boron ester, is shown to be achievable. Excessive alkoxide bases or lithium additives can inhibit or poison the catalyst, while a neopentane diol-based boron ester is crucial for optimal performance.Mechanistic and computational studies have been carried out to investigate the reaction mechanism and explain unexpected observations.
Article
Chemistry, Organic
Yuichiro Kawamoto, Toyoharu Kobayashi, Hisanaka Ito
Summary: Stachyodin A, with a unique spirotetrahydrofuran ring system, was isolated from the roots of Indigofera stachyodes in 2018. The first total synthesis of racemic stachyodin A was accomplished in 14 steps.
Article
Chemistry, Physical
Paul O. Peterson, Matthew Joannou, Eric M. Simmons, Steven R. Wisniewski, Junho Kim, Paul J. Chirik
Summary: The synthesis and characterization of phenoxy(imine) iron(II) alkyl precatalysts for C(sp2)-C(sp3) Suzuki-Miyaura cross-coupling reaction is reported. This method utilizes mild alkoxide bases and nonpolar solvents to achieve high efficiency C(sp2)-C(sp3) bond formation with various aryl boronic esters and alkyl bromides. The study also highlights the compatibility of the precatalysts with base-sensitive functionality and the role of boronate intermediates in transmetalation.
Article
Chemistry, Multidisciplinary
Yan-Long Zheng, Pei-Pei Xie, Omid Daneshfar, Kendall N. Houk, Xin Hong, Stephen G. Newman
Summary: A new method has been developed to convert alkyl esters into alkyl ketones, resulting in the synthesis of 65 different alkyl ketones with various functional groups and heterocyclic structures. The study found that catalyst-controlled chemoselectivity could activate the C(acyl)-O bond in the substrate, while density functional theory calculations supported the mechanism of the nickel catalytic cycle.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.