Article
Energy & Fuels
Borja Lopez-Alonso, Hector Sarnago, Jose M. Burdio, Pablo Briz, Oscar Lucia
Summary: Electroporation is a phenomenon that increases cell membrane permeability through high-intensity electric field application, with significant clinical application in cancer treatment. Achieving complete tumor removal requires homogeneous electric field application, but the complexity of biological tissues makes predicting electric field distribution challenging.
Article
Materials Science, Multidisciplinary
M. Shafayet Zamil, Duane P. Harland, Brian K. Fisher, Michael G. Davis, James R. Schwartz, Anja Geitmann
Summary: Research has shown that hair fiber growth is influenced by a variety of biological, biochemical, and biomechanical factors, with biomechanical factors playing a largely unknown role. A multiscale mechanical modeling approach revealed that biomechanical features such as follicle geometry and keratinization-mediated hardening are likely crucial in hair fiber protrusion. Fine tuning biomechanical parameters is proposed as a key strategy to ensure smooth hair growth.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2021)
Article
Thermodynamics
O. Mukhmetov, D. Igali, A. Mashekova, Y. Zhao, E. Y. K. Ng, S. C. Fok, S. L. Teh
Summary: This study aims to improve the accuracy and reliability of computer-aided diagnosis of breast tumors by using personalized breast geometry and temperature patterns. The research shows that breast geometry plays a crucial role in determining the temperature field and detecting tumors inside the breast, with tumor depth and breast geometry being the key factors for precision tumor detection.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2021)
Article
Chemistry, Physical
Huacui Wang, Yongjun Pan, Xin Liu, Yangzheng Cao, Yue Liu, Xiaoxi Zhang, Ya Mao, Binghe Liu
Summary: With the rapid development of electric vehicles and electronic devices, the safety issues of lithium-ion batteries have been attracting global attention. By leveraging numerical simulation and stacking tests, the study proposes criteria for the mechanical behaviors of battery component materials to mitigate and postpone internal short circuit. These results provide critical insights into the fundamental mechanistic behaviors during internal short circuits and offer design guidance for the next generation of safe batteries.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Engineering, Biomedical
Konstantinos Tzirakis, Christos Panagiotis Papanikas, Vangelis Sakkalis, Eleftheria Tzamali, Yannis Papaharilaou, Alfonso Caiazzo, Triantafyllos Stylianopoulos, Vasileios Vavourakis
Summary: This paper presents a continuum-based finite element framework built on high performance computing and open-source libraries for simulating glioblastoma progression in both 2D and 3D brain models. The framework accurately and efficiently evaluates the impact of vascular density, cancer cell invasiveness and aggressiveness, phenotypic transition potential, and tumor-induced angiogenesis on the evolution of glioblastoma. Individualized simulations using magnetic resonance imaging data are also conducted to study the complex dynamics of the disease.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Daniella L. L. S. Andrade, Raul Guedert, Guilherme B. Pintarelli, Marcelo M. M. Rangel, Krishna D. Oliveira, Priscila G. Quadros, Daniela O. H. Suzuki
Summary: Electrochemotherapy is a selective electrical-based cancer treatment, but using deflected electrodes is not recommended. Mechanical deformations of needle electrodes can affect the distribution of the electric field and cause treatment pitfalls.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Arif Can Gungor, Stefan M. Koepfli, Michael Baumann, Hande Ibili, Jasmin Smajic, Juerg Leuthold
Summary: Graphene has exceptional electronic properties, but traditional semiconductor solvers are not capable of accurately modeling and simulating the charge distribution and transport in graphene. This article proposes two mathematical models to analyze and simulate graphene-based devices. These models are important for the design of future graphene devices.
Review
Biochemistry & Molecular Biology
Zofia Lapinska, Urszula Szwedowicz, Anna Choromanska, Jolanta Saczko
Summary: Gynecological carcinomas are a growing concern and current treatment methods have limited efficacy. Electroporation-based therapies, which reduce drug dosage and increase effectiveness, have gained attention. This review provides an overview of the mechanisms and current applications of electroporation in the treatment of gynecological neoplasms.
Article
Engineering, Biomedical
Girindra Wardhana, Nivedha M. Raman, Momen Abayazid, Jurgen J. Futterer
Summary: This study investigates the impact of electrode orientation on the outcomes of irreversible electroporation (IRE) and verifies the developed numerical models' ability to predict the effects of IRE on potatoes. The results show that a 5 degrees tolerance on the electrode orientation can achieve similar outcomes to the parallel orientation.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2022)
Article
Biophysics
Mitchell Page, Peter E. Linde, Christian M. Puttlitz
Summary: The study developed a finite element model of a TE scaffold unit cell to predict the cellular micromechanical environment (CME) and cell fates under prescribed loading. By characterizing the compressible hyperelastic mechanics of a fibrin hydrogel, it provided a tool for characterizing CME in future studies.
JOURNAL OF BIOMECHANICS
(2021)
Article
Geochemistry & Geophysics
Xiaoxiong Zhu, Jie Liu, Yian Cui, Chunye Gong
Summary: A scalable parallel algorithm for 3-D MT finite element modeling in anisotropic media is designed in this article, utilizing MPI and OpenMP for process and thread parallelisms. The algorithm is validated through model simulations and studies on the effects of topography and conductivity anisotropy on apparent resistivities and phase responses.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2022)
Review
Computer Science, Interdisciplinary Applications
Adrian Moure, Hector Gomez
Summary: Cell motion is crucial for human health and development, and computational models are powerful tools for understanding the mechanisms behind cell migration. The phase-field method is an emerging modeling technique that simplifies the representation of moving cells and their interactions with the environment. This paper provides a comprehensive review of phase-field models for both individual and collective cell migration, showcasing the unique capabilities of this approach through numerical simulations.
ARCHIVES OF COMPUTATIONAL METHODS IN ENGINEERING
(2021)
Article
Multidisciplinary Sciences
M. S. Vidya, K. Sunitha, S. Ashok, Deepak Mishra
Summary: This article introduces a stochastic model for inspecting the spread of electrical trees under lightning impulse voltage. By obtaining numerical solutions of Poisson's equation, computing electric field distributions, and evaluating key parameters of damage through histogram plots, the model's efficiency has been verified through statistical analysis.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2022)
Article
Materials Science, Composites
Peter J. Creveling, John Fisher, Chris Dahlkamp, Michael W. Czabaj
Summary: This study presents a new approach to convert X-ray microcomputed tomography image data into high-fidelity finite element meshes using existing image segmentation and meshing tools. The results demonstrate that the mesh-generation approach allows for modeling distinct interactions between constituents, but the high number of elements required for discretization necessitates further work to improve mesh efficiency.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Geochemistry & Geophysics
Rong Liu, DeShan Feng, RongWen Guo
Summary: This study investigates a 3-D inversion algorithm for frequency-domain airborne electromagnetic (AEM) data based on footprint-guided compact finite element method (CFEM). The accuracy of the algorithm is validated by comparing it to conventional CFEM and testing with different synthetic models. The inversion tests demonstrate the feasibility of combining footprint-guided CFEM with Gauss-Newton optimization in recovering models within an acceptable error level, with good agreement between inversion results and true models.
IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
(2022)
Article
Engineering, Biomedical
Vitalij Novickij, Austeja Baleviciute, Veronika Malysko, Augustinas Zelvys, Eivina Radzeviciute, Bor Kos, Aukse Zinkeviciene, Damijan Miklavcic, Jurij Novickij, Irute Girkontaite
Summary: This study focuses on the use of high repetition frequency unipolar nanosecond pulses for bleomycin electrochemotherapy. It was found that the efficacy of sub-microsecond electrochemotherapy can be manipulated solely by the time delay between pulses.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Helena Cindric, Gorana Gasljevic, Ibrahim Edhemovic, Erik Brecelj, Jan Zmuc, Maja Cemazar, Alenka Seliskar, Damijan Miklavcic, Bor Kos
Summary: This study investigated electroporation in the liver using a numerical mesoscale tissue model. The results showed that liver microstructure does not significantly affect the electric field distribution, but major hepatic vessels and portal spaces do have a significant impact, which should be considered in treatment planning.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Sebastien Chaigne, Daniel C. Sigg, Mark T. Stewart, Meleze Hocini, Tina Batista Napotnik, Damijan Miklavcic, Olivier Bernus, David Benoist
Summary: The study evaluated the effects of a monophasic single electric pulse on the contractility, Ca2+ homeostasis, and recovery of cardiac myocytes. Results showed that electroporation increased intracellular Ca2+ levels immediately, leading to changes in myocyte contraction and Ca2+ homeostasis. Sublethal electric pulses also affected cell contractions and Ca2+ levels, with lethal thresholds depending on cell orientation relative to the electric field.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Brian Howard, Atul Verma, Wendy S. Tzou, Lars Mattison, Bor Kos, Damijan Miklavcic, Birce Onal, Mark T. Stewart, Daniel C. Sigg
Summary: This study evaluated the impact of electrode-tissue proximity on cardiac lesion formation with a biphasic, bipolar PFA system. The results showed that the dimensions of cardiac lesions decreased with a decrease in electrode-tissue distance. Numerical modeling supported the experimental findings. Therefore, close electrode-tissue proximity is beneficial for achieving transmural lesions.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matej Kranjc, Janja Dermol-Cerne, Tjasa Potocnik, Vitalij Novickij, Damijan Miklavcic
Summary: This study demonstrates the feasibility of using high-intensity pulsed electromagnetic field (HI-PEMF) for non-viral delivery of genetic material in vitro. The results show that HI-PEMF can cause DNA adsorption to the cell membrane and induce gene electrotransfection. Endocytosis is also identified as a possible mechanism for introducing large molecules into cells by HI-PEMF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Citlalli Jessica Trujillo-Romero, Juan Dionisio Merida, Texar Javier Ramirez-Guzman, Raquel Martinez-Valdez, Lorenzo Leija-Salas, Arturo Vera-Hernandez, Genaro Rico-Martinez, Jose Jesus Agustin Flores-Cuautle, Josefina Gutierrez-Martinez, Emilio Sacristan-Rock
Summary: Microwave ablation is limited in its application for bone tumor treatment, but newly designed antenna arrays can treat bone tumors larger than 3 cm(3). By evaluating and studying various antenna configurations, lower standing wave ratios and higher ablated tissue volumes can be achieved.
Article
Chemistry, Multidisciplinary
Tjasa Potocnik, Shaurya Sachdev, Tamara Polajzer, Alenka Macek Lebar, Damijan Miklavcic
Summary: In this study, we investigated the potential use of different pulse durations for gene electrotransfer and compared the efficiency and dynamics of transgene expression. We also developed a model for the probability of pDNA and cell membrane contact during electrotransfer.
APPLIED SCIENCES-BASEL
(2022)
Article
Oncology
Helena Cindric, Damijan Miklavcic, Francois H. Cornelis, Bor Kos
Summary: Electroporation has sparked great interest in medical applications. This study presents an algorithm that optimizes electrode positions based on spatial information of the electric field distribution in the target tissue. The algorithm successfully applies to different spinal segments, tumor sizes, and locations within the vertebra. It significantly reduces the time and expertise required for treatment planning of vertebral tumors.
Article
Pharmacology & Pharmacy
Aleksandra Cvetkoska, Janja Dermol-Cerne, Damijan Miklavcic, Simona Kranjc Brezar, Bostjan Markelc, Gregor Sersa, Matej Rebersek
Summary: In this study, a new pulse generator, applicator, and pulse delivery protocol for gene electrotransfer (GET) to skin cells were developed. The results showed that the proposed pulse delivery protocol resulted in higher gene expression in mouse skin cells compared to the currently used pulse generator, applicator, and pulse delivery protocol.
Article
Engineering, Biomedical
Rok Smerc, David A. A. Ramirez, Samo Mahnic-Kalamiza, Janja Dermol-Cerne, Daniel C. C. Sigg, Lars M. M. Mattison, Paul A. A. Iaizzo, Damijan Miklavcic
Summary: The aim of this study was to investigate the influence of electric field orientation in anisotropic muscle tissue on irreversible electroporation damage. In vivo experiments were conducted on porcine skeletal muscle, with the electric field applied parallel or perpendicular to the muscle fibers. Results showed that lesions in the parallel group were consistently smaller and narrower than those in the perpendicular group. The study concludes that muscle anisotropy is a significant factor in determining electric field distribution in electroporation applications. Significance: 8/10
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Lars Mattison, Atul Verma, Khaldoun G. Tarakji, Tobias Reichlin, Gerhard Hindricks, Kevin L. Sack, Birce Onal, Megan M. Schmidt, Damijan Miklavcic, Daniel C. Sigg
Summary: In this study, it was found that contact force in pulsed field ablation (PFA) had minimal effects on lesion dimensions, with only a small increase in depth, width, and volume of the lesions. The importance lies in achieving tissue contact rather than the force applied.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ilse Anahi Torres, Lorenzo Leija, Arturo Vera, Daniela Avila, Hector Maldonado, Josefina Gutierrez, Marisela Carrillo, Mario Ibrahin Gutierrez, Antonio Ramos
Summary: Diabetic foot, characterized by foot ulcerations, is a serious complication in patients with diabetes mellitus. This study proposes systems to measure and identify changes in foot tissues of diabetic patients and healthy subjects, aiming to provide tools for physicians to monitor patients and accurately identify symptom progression. The results reveal an average temperature difference of approximately 2 degrees C and significant impedance differences between diabetic and healthy patients. Skin-related systems can identify the type of macules developed by diabetic patients. By standardizing the diagnosis process, the early detection of diabetic foot becomes possible, supported by easy installation, interpretation, and affordability of these systems.
APPLIED SCIENCES-BASEL
(2023)
Review
Pharmacology & Pharmacy
Tjasa Potocnik, Alenka Macek Lebar, Spela Kos, Matej Rebersek, Eva Pirc, Gregor Sersa, Damijan Miklavcic
Summary: The mechanisms and optimization strategies of nucleic acid delivery with gene electrotransfer (GET) are still not well understood. This article reviews the current state of knowledge through a systematic literature review and meta-analysis of in vitro GET studies, emphasizing the importance of parameter selection and result evaluation.
Article
Chemistry, Applied
Jessica Genovese, Marko Strucic, Igor Sersa, Vitalij Novickij, Pietro Rocculi, Damijan Miklavcic, Samo Mahnic-Kalamiza, Matej Kranjc
Summary: Using magnetic resonance imaging and magnetic resonance electrical impedance tomography, we investigated the non-uniform effect of pulsed electric field (PEF) treatment on plant tissues such as apple, potato, and carrot. The results showed that the distribution of T2 relaxation times became increasingly inhomogeneous as the complexity of the tissue structure increased. The feasibility and potential of using the T2 mapping technique to analyze the effects of PEF on plant tissue structures were demonstrated.
Article
Oncology
Angelika Vizintin, Stefan Markovic, Janez Scancar, Jerneja Kladnik, Iztok Turel, Damijan Miklavcic
Summary: The study found that equivalent nanosecond pulses are equally effective in electrochemotherapy as standardly used 8 x 100 mu s pulses. The number of intracellular cisplatin molecules strongly correlates with cell survival for B16F1 cells, but less for CHO cells, implying the possible involvement of other mechanisms in electrochemotherapy. High-voltage electric pulses do not alter the structure of cisplatin.
RADIOLOGY AND ONCOLOGY
(2022)
