Article
Multidisciplinary Sciences
Lucas Buk Cardoso, Vanderlei Cunha Parro, Stela Verzinhasse Peres, Maria Paula Curado, Gisele Aparecida Fernandes, Victor Wuensch Filho, Tatiana Natasha Toporcov
Summary: Colorectal cancer is a prevalent cancer worldwide, with about 2 million new cases annually. Machine learning algorithms have been increasingly used in cancer studies, providing important information and predictions based on data. This study used patient data from São Paulo, Brazil and five different classification algorithms to predict survival in colorectal cancer patients, achieving an accuracy of approximately 77% with an AUC of 0.86, with clinical staging being the most important feature.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Xiaofei Cheng, Yanqing Li, Dong Chen, Xiangming Xu, Fanlong Liu, Feng Zhao
Summary: In this study, we developed a unique nomogram incorporating clinical and pathological characteristics to predict the survival of young-onset patients with CRLM. The nomogram showed high accuracy and sensitivity, and was superior to the traditional TNM staging system in predicting survival.
Article
Gastroenterology & Hepatology
Joshua Franklyn, Joe Lomax, Peter L. Z. Labib, Amy Baker, Supriya Balasubramanya, Joe Natale, Muhammad Abdalkoddus, Joanne Hosking, Mark G. Coleman, Sebastian Smolarek
Summary: This study analyzed the demographics, clinicopathological features, and prognosis of young colorectal cancer (CRC) patients in England. The results showed that young patients had a higher prevalence of right-sided colon cancer and better overall and relative survival rates compared to older patients with CRC.
COLORECTAL DISEASE
(2022)
Article
Oncology
Asimina Koulouridi, Michaela Karagianni, Ippokratis Messaritakis, Maria Sfakianaki, Alexandra Voutsina, Maria Trypaki, Maria Bachlitzanaki, Evangelos Koustas, Michalis Karamouzis, Anastasios Ntavatzikos, Anna Koumarianou, Nikolaos Androulakis, Dimitrios Mavroudis, Maria Tzardi, John Souglakos
Summary: The study reveals that KRAS G12D mutation is associated with better overall survival, while KRAS G12C mutation may indicate worse prognosis in terms of progression-free and overall survival. KRAS exon 3 and exon 4 mutations also have different impacts on progression-free and overall survival.
Article
Biochemistry & Molecular Biology
Lulu Tan, Xiakeerzhati Xiaohalati, Feng Liu, Jia Liu, Haoyu Fu, Yang Zhang, Jinbo Gao, Kaixiong Tao, Guobin Wang, Lin Wang, Zheng Wang
Summary: In order to explore the effects of aging on colorectal cancer (CRC) progression and treatment outcomes, this study established aging subtypes using 28 aging-related genes. The aging subtype of CRC showed distinct molecular features, higher frequencies of TP53 and immune checkpoint molecules, and high sensitivity to certain inhibitors. A risk signature based on 14 aging-related genes was also constructed, which exhibited good prediction and discrimination power. These findings provide new opportunities for personalized treatment and prognosis evaluation of CRC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Il Tae Son, Jae Hyun Kang, Byung Chun Kim, Jun Ho Park, Jong Wan Kim
Summary: The aim of this study was to compare the clinicopathologic features and prognosis of young patients with colorectal cancer (CRC) with older patients. The results showed that young patients had more symptoms, aggressive histological features, received more adjuvant chemotherapy and multidrug agents, and had a better prognosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Karla Montalban-Hernandez, Ramon Cantero-Cid, Roberto Lozano-Rodriguez, Alejandro Pascual-Iglesias, Jose Avendano-Ortiz, Jose Carlos Casalvilla-Duenas, Gloria Cristina Bonel Perez, Jenny Guevara, Cristobal Marcano, Cristina Barragan, Jaime Valentin, Carlos del Fresno, Luis Augusto Aguirre, Eduardo Lopez Collazo
Summary: Among colorectal cancer patients, the level of soluble SIGLEC5 may serve as a potential prognostic marker and predictor of patient outcomes.
Article
Medicine, General & Internal
Manon C. W. Spaander, Ann G. Zauber, Sapna Syngal, Martin J. Blaser, Joseph J. Sung, Y. Nancy You, Ernst J. Kuipers
Summary: In the past decades, the incidence of early-onset colorectal cancer (CRC) or young-onset CRC (YO-CRC) has increased globally in both men and women. About 20% of YO-CRC patients have a hereditary cancer syndrome, while most cases have no genetic predisposition. Lifestyle changes such as antibiotic use, low physical activity, and obesity since the 1950s have been suggested as important factors in YO-CRC development by affecting the gut microbiome. Long-term prospective studies with childhood lifestyle data are needed to better understand the underlying mechanisms and relationships between environmental factors and YO-CRC.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Multidisciplinary Sciences
Hyangkyoung Kim, In Ja Park, Youngjin Han, Tae-Won Kwon, Yong-Pil Cho
Summary: This study revealed that CRC patients are at risk for developing new-onset CVD, which is associated with reduced survival. The atherosclerotic burden in the aorta or both iliac arteries may help predict future CVD events.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Gastroenterology & Hepatology
Giandomenico Roviello, Daniele Lavacchi, Lorenzo Antonuzzo, Martina Catalano, Enrico Mini
Summary: Liquid biopsy is a promising tool in the clinical management of colorectal cancer, with the potential for diagnosis, prognosis, monitoring, and treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Shuyuan Wang, Zhen Yuan, Kemin Ni, Yixiang Zhan, Xuanzhu Zhao, Zhaoce Liu, Yanfei Liu, Ben Yi, Sizhen Lai, Xin Yin, Xingyu Zhou, Yuqi Wang, Hangyu Ping, Ran Xin, Wenhong Wang, Hongzhou Li, Yuanshun Zhao, Youkui Han, Weifeng Gao, Xinlei Jin, Guihua Wang, Zili Zhang, Guoxun Li, Qinghuai Zhang, Xipeng Zhang, Hong Ma, Chunze Zhang
Summary: This study analyzed the prognosis and postoperative treatment of young and older patients with colorectal cancer. The results showed that young patients had a lower survival rate within 25 months after surgery compared to older patients, but their survival rate was significantly better after 25 months. Furthermore, young patients were more likely to receive chemotherapy, and the choice of chemotherapy regimen did not significantly affect their overall survival.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2022)
Article
Oncology
Chao Chen, Da Wang, Xiaoxu Ge, Jian Wang, Yuhuai Huang, Tianyi Ling, Tian Jin, Jinhua Yang, Fengping Wang, Weihong Wu, Lifeng Sun
Summary: Surgical treatment of metastatic sites is effective and safe for CRC patients with OM. CC-0 is recommended for improved prognosis, while the scoring system developed in this study is effective for prediction of OS of patients after surgery.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alvaro Gutierrez, Hannah Demond, Priscilla Brebi, Carmen Gloria Ili
Summary: Colorectal cancer is the third most common cancer globally, and biomarkers play a crucial role in diagnosis and predicting metastasis. Key signaling pathways associated with cancer progression include the MAPK pathway, p53 pathway, and TGF-beta pathway.
Article
Genetics & Heredity
Xiaopeng Wang, Ruirong Lin, Yi Zeng, Yi Wang, Shenghong Wei, Zhitao Lin, Shu Chen, Zaisheng Ye, Luchuan Chen
Summary: In this study, the potential prognostic value of FCRLB in colorectal cancer (CRC) was identified through TCGA database analysis. FCRLB was found to be highly expressed in CRC tissues compared to normal tissues. High expression of FCRLB correlated with adverse clinicopathological features such as elevated CEA levels, advanced tumor stage, lymphatic invasion, perineural invasion, and incomplete resection. Additionally, high expression of FCRLB was associated with poorer overall survival, disease-specific survival, and progression-free survival. Further validation using tissue microarray confirmed these findings.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Jae Hyun Kim, Jongwook Yu, Dong Keon Kim, Seunghun Lee, Seung Hyun Lee, Byung Kwon Ahn, Tae Il Kim, Seun Ja Park
Summary: This study suggests that the tumor microbiome may be a potential predictor of postoperative disease recurrence in patients with colorectal cancer. The microbial diversity and abundance differ between tumor and adjacent tissues, and a prediction model using tumor tissue microbiome data performs better than clinical factors, especially in female patients.
FRONTIERS IN ONCOLOGY
(2023)