Review
Biochemistry & Molecular Biology
Francisca Ferrer-Marin, Ernesto Jose Cuenca-Zamora, Pedro Jesus Guijarro-Carrillo, Raul Teruel-Montoya
Summary: In patients with chronic Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), leukocytes play a significant role in thrombosis. Neutrophils and monocytes in MPN patients show a pro-coagulant activated phenotype and release extracellular neutrophil traps (NETs) that contribute to platelet activation and coagulation mechanisms. Therapeutic strategies targeting NETs may reduce thrombotic complications in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Rhiannon Morris, Liesl Butler, Andrew Perkins, Nadia J. Kershaw, Jeffrey J. Babon
Summary: LNK is an adaptor protein that regulates cytokine signaling and constrains the activation of the JAK-STAT pathway. Mutations in LNK can lead to increased signaling and contribute to various hematological and inflammatory diseases.
Review
Biochemistry & Molecular Biology
Dominik Kiem, Sandro Wagner, Teresa Magnes, Alexander Egle, Richard Greil, Thomas Melchardt
Summary: Philadelphia chromosome negative myeloproliferative neoplasms consist of polycythemia vera, essential thrombocytosis, and primary myelofibrosis. Mutations in JAK2, MPL, or CALR characterize these disorders, with additional mutations leading to myeloid cell lineages expansion and marrow fibrosis in PMF. Chronic inflammation plays a significant role in the disease initiation and progression, with neutrophilic granulocytes playing a major role in the pathogenesis of thromboembolic events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Hematology
Heike L. Pahl
Summary: The identification of sentinel mutations in MPN patients, which significantly increase the risk of leukemic transformation, even when not present in leukemic cells, is a crucial advancement in understanding and managing the disease. These mutations act as early indicators of potential disease progression, similar to canaries in a coal mine.
Editorial Material
Hematology
Ana Rio-Machin, Jude Fitzgibbon
Summary: In this study, Li et al and Duployez et al investigate the clinical and genetic landscape of DDX41 germline variants in patients with acute myeloid leukemia (AML). They find that AML with DDX41 germline variants represents a distinct subtype characterized by late-onset disease, normal karyotype, male sex skewing, and favorable outcome.
Review
Biochemistry & Molecular Biology
Valeria Di Battista, Maria Teresa Bochicchio, Giulio Giordano, Mariasanta Napolitano, Alessandro Lucchesi
Summary: The past decade has seen significant advancements in the understanding of chronic myeloproliferative neoplasms through preclinical research. The translational implications of these new biological discoveries inform future therapeutic strategies, with a focus on the role of inflammasomes in guiding and impacting the disease's natural history. Greater knowledge in this area has the potential to lead to improved care for patients with MPNs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Alberto Alvarez-Larran, Anna Angona, Marcio Andrade-Campos, M. Soledad Noya, M. Teresa Gomez-Casares, Beatriz Cuevas, Gonzalo Caballero, Carmen Garcia-Hernandez, Valentin Garcia-Gutierrez, Alicia Palomino, Francisca Ferrer-Marin, M. Isabel Mata-Vazquez, Ana Moreto, Elena Magro, Ilda Murillo, Juan Manuel Alonso-Dominguez, Jose Maria Guerra, Lucia Guerrero, Jose Maria Raya, Manuel Perez-Encinas, Gonzalo Carreno-Tarragona, Laura Fox, Irene Pastor-Galan, Beatriz Bellosillo, Juan Carlos Hernandez-Boluda
Summary: The study found that CALR-positive patients had a shorter time from diagnosis to cytoreduction compared to other genotypes, but had poorer outcomes in terms of median time to complete hematological response and duration of response. CALR-mutated patients exhibited higher rates of resistance/intolerance to hydroxycarbamide. Therefore, new treatment modalities and redefinition of hematologic targets are needed for patients with CALR-mutated essential thrombocythemia.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Cell Biology
Kengo Takeda, Kenji Tago, Megumi Funakoshi-Tago
Summary: The point mutation (V617F) in the JAK2 gene promotes the expression of DDX5, which contributes to the development of MPN through the activation of STAT5. Inhibition of DDX5 suppresses mTOR activation, cell proliferation, and tumor growth in a mouse model of MPN.
CELLULAR SIGNALLING
(2023)
Article
Clinical Neurology
Mitsuru Shinohara, Ghupurjan Gheni, Junichi Hitomi, Guojun Bu, Naoyuki Sato
Summary: This study investigates the relationship between apolipoprotein E (APOE) genotype and obesity in dementia. The results suggest that obesity is associated with cognitive decline in midlife individuals without APOE4, while it may ease cognitive impairment in individuals with dementia, especially those with APOE4, by protecting against Alzheimer's pathologies.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Elisa Parciante, Cosimo Cumbo, Luisa Anelli, Antonella Zagaria, Immacolata Redavid, Angela Minervini, Maria Rosa Conserva, Giuseppina Tota, Nicoletta Coccaro, Francesco Tarantini, Crescenzio Francesco Minervini, Maria Giovanna Macchia, Giorgina Specchia, Pellegrino Musto, Francesco Albano
Summary: NLRP3 is an extensively studied inflammasome member that, when overactivated, can drive several carcinomas. It is activated by different signals and plays a crucial role in metabolic disorders, inflammatory diseases, and autoimmune diseases. NLRP3 belongs to the pattern recognition receptors (PRRs) family, is expressed in various immune cells, and primarily functions in myeloid cells. Investigating the NLRP3 inflammasome complex is a novel horizon for exploration, and inhibiting IL-1 beta or NLRP3 could be a beneficial therapeutic strategy for cancer, improving existing protocols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Giuseppe Lanzarone, Matteo Olivi
Summary: Myeloproliferative neoplasms are clonal stem cell disorders characterized by clonal proliferation of myeloid cells, with cytogenetics analysis providing valuable prognostic information in the evaluation of MPNs.
MEDICINA-LITHUANIA
(2021)
Review
Cell Biology
Elena Masselli, Giulia Pozzi, Cecilia Carubbi, Marco Vitale
Summary: Myeloproliferative neoplasms are hematologic malignancies with a significant heritable component that can be affected by germline variants. Host genetic factors play a role in determining the phenotypic presentation, outcome, and response to therapy of MPNs. Understanding the genetic determinants of clonal hematopoiesis can provide insights into the development of hematologic neoplasms.
Review
Biochemistry & Molecular Biology
Dragana C. Markovic, Irina S. Maslovaric, Marijana Kovacic, Sanja Vignjevic Petrinovic, Vesna Lj. Ilic
Summary: Myeloproliferative neoplasms (MPNs) are hematologic malignancies characterized by gene mutations and abnormal signaling pathways. Chronic inflammation is believed to play a key role in the progression of MPNs. Neutrophils in MPNs show abnormal activation and apoptotic machinery, leading to inflammation and the formation of neutrophil extracellular traps (NETs). NETs induce hematopoietic precursor proliferation in the bone marrow microenvironment, affecting hematopoietic disorders. This review discusses the potential pathophysiological significance of NET formation in MPNs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Lucia Catani, Michele Cavo, Francesca Palandri
Summary: Myeloproliferative Neoplasms (MPN) are a group of acquired clonal disorders of hematopoietic stem cells, including Essential Thrombocythemia, Polycythemia Vera, and Myelofibrosis. MPN are characterized by mutations in three driver genes and chronic inflammation, leading to increased risk of thrombosis, disease progression, and other complications. Extracellular vesicles (EVs) play a crucial role in blood cancers by mediating cell-cell communication and potentially serving as diagnostic and prognostic biomarkers.
Letter
Oncology
Antonella Zagaria, Francesco Tarantini, Paola Orsini, Luisa Anelli, Cosimo Cumbo, Nicoletta Coccaro, Giuseppina Tota, Crescenzio Francesco Minervini, Elisa Parciante, Maria Rosa Conserva, Immacolata Redavid, Alessandra Ricco, Immacolata Attolico, Giorgina Specchia, Pellegrino Musto, Francesco Albano
Summary: This study investigated the genomic and clinical features of 80 erythrocytosis patients and found that male patients with idiopathic erythrocytosis and normal EPO levels may be the best candidates for searching for the JAK2 GGCC_46/1 haplotype and CALR rs1049481_G allele.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jerome Lavoue, Igor Burstyn
Summary: A study compared the performance of a new statistical model and the traditional lognormal model in simulation, finding that the traditional approach tended to overestimate noncompliance in cases where most censored values were zeros. The newly proposed Bernoulli-lognormal model provides a suitable and accessible alternative for data with a substantial proportion of censored values, ensuring unbiased risk assessments.
ANNALS OF WORK EXPOSURES AND HEALTH
(2021)
Article
Statistics & Probability
Li Xing, Xuekui Zhang, Igor Burstyn, Paul Gustafson
Summary: The article discusses the shape of the relationship between a continuous exposure variable and a binary disease variable, investigating methods for inferring the shape in epidemiologic investigations and risk assessments, as well as the precise inference of the median effect of exposure. The study utilizes a family based on the Box-Cox transformation to address exposure-disease relationships.
CANADIAN JOURNAL OF STATISTICS-REVUE CANADIENNE DE STATISTIQUE
(2021)
Article
Public, Environmental & Occupational Health
Igor Burstyn, Tran Huynh
Summary: During the COVID-19 pandemic, changes in work patterns increased the risk of anxiety and depression, especially in non-essential low-income industries. The significant disruption of working lives may be a major factor contributing to heightened anxiety and depression.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Neal D. Goldstein, Deborah Kahal, Karla Testa, Igor Burstyn
Summary: The study demonstrates how selection into a healthcare facility can introduce bias in a study of community deprivation and chronic hepatitis C virus infection, affecting the association between the two factors. Inverse probability weighting may help mitigate this bias.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Oncology
Derrick G. Lee, Johanna M. Schuetz, Agnes S. Lai, Igor Burstyn, Angela Brooks-Wilson, Kristan J. Aronson, John J. Spinelli
Summary: This study identified an association between genetic variants of XMGs and female breast cancer, with specific variants increasing the risk. The effects of occupational PAH exposure varied among carriers of certain genetic variants, indicating an interplay between genetic and environmental factors impacting breast cancer risk.
Article
Public, Environmental & Occupational Health
Nicola Cherry, Trish Mhonde, Anil Adisesh, Igor Burstyn, Quentin Durand-Moreau, France Labreche, Shannon Ruzycki
Summary: During the early months of the Covid-19 pandemic, healthcare workers (HCWs) were at increased risk of infection. Few modifiable risks were identified. It is largely unknown how these evolved over time. A prospective case-referent study was conducted in Canada to assess the changes in workplace factors associated with Covid-19 infection among HCWs. The results indicate that the risks have been largely contained in Canada but continued vigilance is needed.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Tran B. B. Huynh, Leslie A. A. McClure, Virginia J. J. Howard, Monika M. M. Stafford, Suzanne E. E. Judd, Igor Burstyn
Summary: The study aimed to identify occupations with elevated risk of stroke. The study found that longer employment in protective service, food preparation and service, and transportation and material moving occupations may increase the risk of stroke.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Igor Burstyn, Geoffrey H. Donovan, Yvonne L. Michael, Sarah Jovan
Summary: This study used moss as a bio-indicator to evaluate the atmospheric deposition of PAHs in Portland, Oregon. By simultaneously measuring PAH-DNA adducts in the blood of nearby residents, the study investigated whether the measurements from bio-indicators are good proxies for human exposure. The results did not show a clear association between PAH levels in moss and PAH-DNA adducts in blood, but higher adduct levels were observed in individuals who used wood fire.
Article
Public, Environmental & Occupational Health
Wenxin Wan, Calvin B. Ge, Melissa C. Friesen, Sarah J. Locke, Daniel E. Russ, Igor Burstyn, Christopher J. O. Baker, Anil Adisesh, Qing Lan, Nathaniel Rothman, Anke Huss, Martie van Tongeren, Roel Vermeulen, Susan Peters
Summary: The objective of this study is to compare the performance of different automatic job coding tools in terms of job coding and Job-Exposure Matrix (JEM)-assigned exposures. The results show that CASCOT performs better in terms of job coding and exposure assignment, but study-specific evaluations and tool improvements are still needed.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Nursing
Igor Burstyn, Karyn Holt
Summary: The study aims to examine the themes of challenging and distressing events reported by healthcare workers during the first wave of the COVID-19 pandemic in two US health care systems, and relate them to behavioral theory and measures of anxiety and depression.
Article
Obstetrics & Gynecology
Xi Wang, Nora L. Lee, Igor Burstyn
Summary: A study found that among pregnant smokers, there are four subgroups with different utilization patterns of quitting methods, including not trying to quit, trying to quit on their own, using e-cigarettes, and utilizing multiple methods. Pregnant women who tried to quit on their own were more likely to be abstinent or reduce smoking amount in late pregnancy, and these improvements lasted into early postpartum.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Public, Environmental & Occupational Health
Igor Burstyn, Philippe Sarazin, George Luta, Melissa C. Friesen, Laurel Kincl, Jerome Lavoue
Summary: This study developed a predictive model for the volume of air sampled in non-detected measurements in the US Integrated Management Information System (IMIS). The CART models successfully predicted the sampled air volume and may guide future work on handling non-detects in IMIS. Separate predictive models should be developed for each substance, industry, and year of interest.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Medicine, General & Internal
Nicola Cherry, Anil Adisesh, Igor Burstyn, Quentin Durand-Moreau, Jean-Michel Galarneau, France Labreche, Shannon M. Ruzycki, Tanis Zadunayski
Summary: This study aims to identify modifiable workplace risk factors for infection and mental ill health among healthcare workers during the COVID-19 pandemic. Participants were recruited from multiple provinces in Canada and underwent serology testing and questionnaires before and after vaccination.
Editorial Material
Public, Environmental & Occupational Health
Igor Burstyn, Rachael M. Jones
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Letter
Public, Environmental & Occupational Health
Neal D. Goldstein, Igor Burstyn
AMERICAN JOURNAL OF PUBLIC HEALTH
(2022)