Article
Chemistry, Analytical
Xiao Zhang, Xin-Yi Jiang, Shuai Chen, Yong-Liang Yu, Jian-Hua Wang
Summary: Dried blood spot (DBS) detection is a convenient and reliable method for large-scale evaluation of arsenic exposure in human population. A Lego-spinner pretreatment device is designed for speciation analysis of arsenic in DBSs by IC-ICP-MS. The device can extract and separate arsenic species from the blood matrix efficiently, and the concentrations of arsenic species in the DBS are highly correlated with those in whole blood. The DBS sampling approach can effectively preserve arsenic species for at least 30 days, and the contents of arsenic species in DBSs prepared from capillary blood are in agreement with venous whole blood.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Francisco L. F. da Silva, Francisco E. H. Lima, Davino M. Andrade Neto, Fernando L. de Menezes, Lillian M. U. D. Fechine, Abdullah Akhdhar, Livia P. D. Ribeiro, Ana R. A. Nogueira, Pierre B. A. Fechine, Gisele S. Lopes, Wladiana O. Matos
Summary: An alternative analytical method using ICP OES was developed for quantifying inorganic arsenic (iAs) in rice. Iron nanoparticles modified with an organophosphorus compound were used to extract iAs from the plant matrix. The proposed method demonstrated satisfactory precision, LOD, and LOQ, with tAs contents between 0.090 and 0.295 mg kg-1 and iAs mass fractions between 0.055 and 0.109 mg kg-1 in rice samples.
Article
Chemistry, Applied
Semih Kara, Dotse Selali Chormey, Ahmet Saygilar, Sezgin Bakirdere
Summary: This study utilized a combination of high-performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICP-MS) to separate and quantify six arsenic species. The method demonstrated high sensitivity and accuracy, with limits of detection ranging between 0.14-0.29 ng/mL. Spike recovery experiments on rice samples validated the method's applicability to complex matrices, with recovery results ranging between 93 and 109%. Triplicate measurements on all spiked samples recorded percent relative standard deviation values below 10%, indicating the reliability and precision of the method.
Article
Biochemical Research Methods
Maria S. Jimenez, Mariam Bakir, Daniel Isabal, Maria T. Gomez, Josefina Perez-Arantegui, Juan R. Castillo, Francisco Laborda
Summary: In this study, hydrodynamic chromatography coupled to inductively coupled plasma mass spectrometry was used to simultaneously determine dissolved and nanoparticulate species of gold and silver, with optimized mobile phase for resolution and recovery. The developed methods allowed for quick and accurate detection of nanoparticulate and dissolved species of gold and silver in dietary supplements, showing good agreement with other analysis methods. Due to achievable resolution, the quality of quantitative results is influenced by the relative abundance and size of nanoparticles present.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Faizan Ur Rehman Qaiser, Fan Zhang, Ramesh Raj Pant, Chen Zeng, Nangyal Ghani Khan, Guanxing Wang
Summary: This study assessed the geochemical characteristics and associated health risks of arsenic in natural waters in the Indus River Basin (IRB), Pakistan. A total of 203 samples of different water types were collected and analyzed. The results showed that arsenic concentrations in the waters ranged from 1.1-26.45, 1.05-44.44, and 0.67-41.09 μg/L for surface water, shallow groundwater, and deep groundwater, respectively. The desorption of arsenic in oxidizing environments with elevated pH and Eh was identified as the controlling mechanism.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Xiao Zhang, Shuang Liu, Xing Wei, Yong-Liang Yu, Jian-Hua Wang
Summary: This novel pretreatment device allows rapid extraction and separation of arsenic species in whole blood with high efficiency and simple operation, providing a convenient tool for studying arsenic exposure and toxicity.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
M. Ribeiro, E. Galli, T. Guerin, J. A. L. Silva, I. Castanheira, A. Leufroy, P. Jitaru
Summary: This study presents the development and validation of a new analytical method for simultaneous speciation analysis of selenium and mercury in fish muscle. The method involves the extraction and separation of the different species using microwave-assisted enzymatic hydrolysis and HPLC with a specific column and mobile phase. The method was validated and successfully applied to analyze muscle samples from various fish species.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Taimon Francis Moran Hoyne, Luiza Valli Vieira, Otavio A. Heringer, Geisamanda P. Brandao, Jefferson Rodrigues de Souza, Maria Tereza W. D. Carneiro
Summary: Arsenic speciation analysis was conducted on solid canned tuna samples, which were stored in oil and brine, using IC-ICP-MS. The method was optimized and validated, and the extraction of arsenic species was performed using (NH4)(2)CO3 at pH 10.5. The analysis showed that the total arsenic levels in the samples exceeded the limits set by Brazilian sanitary standards, but the major species detected was the non-toxic arsenobetaine.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Chemistry, Analytical
Satoki Okabayashi, Leona Kawane, Nanda Yusentri Mrabawani, Takahiro Iwai, Tomohiro Narukawa, Motohiro Tsuboi, Koichi Chiba
Summary: A novel technique using HILIC combined with ICP-MS was developed to identify and quantify Gd-based contrast agents in river water. The study found both known Gd-based contrast agents and unidentified Gd compounds in river water samples, suggesting potential transformation or dissociation of Gd chelates during treatment in WWTP.
Article
Chemistry, Analytical
Andrew Williams, Diane Beauchemin
Summary: The determination of size and composition of nanoparticles is important for various industries. The traditional analysis techniques have limitations in sample introduction and sensitivity. This study proposes a monosegmented flow analysis method, which simplifies the sample introduction process, improves sample throughput and transport efficiency, and enhances sensitivity for dissolved analyte without degrading the measurement of nanoparticles.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Chemistry, Analytical
Mokgehle R. Letsoalo, Messai A. Mamo, Abayneh A. Ambushe
Summary: By investigating optimal chromatographic separation conditions, polyatomic ions interference correction, and extraction parameters, successful simultaneous extraction and quantification of As and Cr species was achieved with excellent resolution.
ANALYTICAL LETTERS
(2021)
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: By combining ICP OES with a novel FIGA mode, a more sensitive determination of Hg was achieved. The proposed method showed a much higher analytical signal for Hg compared to conventional PN-ICP OES, resulting in a significantly improved detection limit (0.035 μg/L) and measurement precision (2.5%). It also offered a 4 times lower detection limit compared to CVG-ICP OES (0.15 μg/L).
Article
Green & Sustainable Science & Technology
Zulfiqar Ali Sahito, Afsheen Zehra, Lin Tang, Zarina Ali, Muhammad Laeeq ur Rehman Hashmi, Nabila Bano, Muhammad Asmat Ullah, Zhenli He, Xiaoe Yang
Summary: The study found significant variations in oilseed sunflower's performance in remediation of arsenic and mercury-contaminated soil, ligno-cellulosic mass production of bioenergy, and metal uptake potential. Some accessions showed good lignocellulosic components and oil production, making them suitable for effective remediation of contaminated soils.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Chemistry, Analytical
Seon-Jin Yang, Yonghoon Lee, Sang-Ho Nam
Summary: The toxicity and biological activity of arsenic depend on its chemical form. Inorganic arsenics are more toxic than organic ones. Accurate analysis of arsenic speciation is important for toxicity assessment, in addition to determining total arsenic content.
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY
(2022)
Review
Chemistry, Analytical
Alastair Kierulf, Diane Beauchemin
Summary: When conducting a risk assessment, measuring bioaccessibility using continuous on-line leaching method (COLM) coupled directly to inductively coupled plasma mass spectrometry (ICPMS) provides efficient and accurate results. COLM-ICPMS offers unique features compared to conventional batch methods and falls within accepted control limits. It enables the determination of bioaccessibility for potentially toxic elements in various food samples and provides source information for lead (Pb) in samples.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Engineering, Environmental
Sulakshana Shenoy, Chitiphon Chuaicham, Takamasa Okumura, Karthikeyan Sekar, Keiko Sasaki
Summary: This study utilizes an in-situ simple tactic polycondensation method to produce porous graphitic carbon nitride nanosheets on CaFe2O4 particles, forming a quasi-polymeric heterojunction. The heterojunction traps excited electrons through interfacial electron trap states, preventing charge carrier recombination and enhancing pollutant degradation rates.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Intan Nurul Rizki, Takumi Inoue, Chitiphon Chuaicham, Sulakshana Shenoy, Assadawoot Srikhaow, Karthikeyan Sekar, Keiko Sasaki
Summary: The crude extract of cinnamon was used to synthesize silver nanoparticles, which were then used to fabricate a composite material consisting of silver nanoparticles decorated on zinc oxide for photocatalytic reduction of hexavalent chromium. Various analyses were performed to study the optical and physicochemical properties of the composite material, comparing it with pure zinc oxide. The optimized composite material showed significantly enhanced reduction rate of hexavalent chromium compared to pure zinc oxide, attributed to improved separation and transportation of photogenerated electron-hole pairs and narrowing of the energy band gap.
Article
Chemistry, Physical
Chitiphon Chuaicham, Yuto Noguchi, Sulakshana Shenoy, Kaiqian Shu, Jirawat Trakulmututa, Assadawoot Srikhaow, Karthikeyan Sekar, Keiko Sasaki
Summary: Pd nanoparticles were successfully deposited on Fe(III)-modified hydroxyapatite (HAp) and used as a photocatalyst for simultaneous H-2 evolution and xylose conversion. Pd@FeHAp exhibited higher xylose conversion and increased lactic acid and formic acid production compared to pristine HAp and FeHAp. The Pd@FeHAp composite showed improved photocatalytic activity, attributed to the separation and transport of photogenerated electron-hole pairs, as well as a decrease in electron trap density and energy band gap.
Article
Chemistry, Physical
Sulakshana Shenoy, Mohsen M. Farahat, Chitiphon Chuaicham, Karthikeyan Sekar, Boopathy Ramasamy, Keiko Sasaki
Summary: Brazilian hematite can be transformed into a heterophase photocatalyst via a simple heat treatment process, and its photocatalytic performance is significantly enhanced by combining with g-C3N4. The degradation efficiency of ofloxacin is 4.8 times higher compared to pure g-C3N4. The catalyst exhibits good stability and the mechanism of degradation involves superoxide anion radicals and holes.
Article
Geochemistry & Geophysics
Ahmed M. Elmahdy, Hajime Miki, Keiko Sasaki, Mohsen Farahat
Summary: The effect of microwave pre-treatment on the magnetic properties of tennantite and enargite was investigated. Magnetic susceptibility, XRD, and XPS characterization were conducted to explore the changes in their magnetic properties. Magnetic separation of chalcopyrite binary mixtures with enargite and tennantite was performed, showing significant arsenic rejection rates of 84.2% and 76.3% respectively.
Article
Engineering, Environmental
Assadawoot Srikhaow, Chitiphon Chuaicham, Sulakshana Shenoy, Jirawat Trakulmututa, Keiko Sasaki
Summary: This work reports the construction and performance of heterojunction between oxygen-doped graphitic carbon nitride and artificial steel converter slag (OCN/artCS) as efficient photocatalysts for the conversion of biomass-derived monosaccharide to lactic acid. The OCN/artCS composites exhibited higher photocatalytic performance and effective separation of photogenerated charge carriers. At the optimal content of artCS in the composites, 99% glucose conversion and 90% lactic acid yield were achieved within 60 minutes at 50 degrees Celsius under simulated sunlight irradiation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Geochemistry & Geophysics
Shuang Xu, Binling Guo, Keiko Sasaki, Xinhong Qiu
Summary: This study investigated the influence of Mg doping on the removal of borate by CaAl-layered double hydroxides (LDHs) at different calcination temperatures. The results showed that Mg doping increased the BET surface area and enhanced the adsorption capacity of uncalcined LDHs, especially at high borate concentrations. However, at high calcination temperatures, Mg-doped LDHs had a slightly better adsorption effect at low borate concentrations, but deteriorated at high concentrations due to the crystallinity and morphology changes.
Article
Chemistry, Multidisciplinary
Changshuai Chen, Keiko Sasaki, Quanzhi Tian, Haijun Zhang
Summary: This study compared two preparation methods for synthesizing a coal gasification slag-based one-part geopolymer and found a more suitable method for this purpose. By modifying the preparation method, the compressive strength of the geopolymer was improved and the degree of polymerization was enhanced.
Article
Chemistry, Analytical
Chitiphon Chuaicham, Jirawat Trakulmututa, Sulakshana Shenoy, Vellaichamy Balakumar, Phatchada Santawaja, Shinji Kudo, Karthikeyan Sekar, Keiko Sasaki
Summary: Iron oxalate from converter slag (FeOX-Slag) was synthesized and exhibited better photocatalytic activity in the degradation of rhodamine B compared to commercial iron oxide (Fe2O3).
Article
Chemistry, Analytical
Chitiphon Chuaicham, Sulakshana Shenoy, Jirawat Trakulmututa, Vellaichamy Balakumar, Phatchada Santawaja, Shinji Kudo, Karthikeyan Sekar, Keiko Sasaki
Summary: Iron oxalate dihydrate (FOD-ore) was synthesized from iron ore through oxalic acid extraction and photo-reduction. Various characterization techniques were used to determine the physicochemical properties of FOD-ore, which showed improved photocatalytic activity compared to commercial hematite (Fe2O3). FOD-ore demonstrated efficient degradation of rhodamine B (RhB) due to its enhanced light absorption and enhanced separation and transport of photogenerated electron-hole pairs. Therefore, FOD-ore has potential as a photocatalyst for the degradation of organic pollutants under light irradiation.
Article
Chemistry, Multidisciplinary
Mani Preeyanghaa, Chitiphon Chuaicham, Sulakshana Shenoy, Bernaurdshaw Neppolian, Keiko Sasaki, Karthikeyan Sekar
Summary: In this article, a sapiential method for producing highly effective oxygen-containing CN with hierarchical porous hollow nanotubes (HTCN) is presented using thermal polycondensation of oxalic acid-assisted supramolecular aggregates. Due to the synergistic effect of spatial charge separation and optical absorption ability, HTCN outperforms pristine CN nanosheets (NSCN) in photocatalytic hydrogen production. This research will provide a novel cognitive perspective and understanding for constructing contemporary hydrogen production photocatalysts.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Mani Preeyanghaa, Chitiphon Chuaicham, Sulakshana Shenoy, Balakumar Vellaichamy, Wei Li, Kamaraj Manokaran, Elumalai Varathan, Bernaurdshaw Neppolian, Bunsho Ohtani, Keiko Sasaki, Karthikeyan Sekar
Summary: We developed novel photocatalyst Fe2O3/CuxO/TiO2(B) nanofibers (CFTNF-y) through in situ photodeposition strategy, which exhibited significantly enhanced photocatalytic hydrogen production activity and trimethoprim (TMP) removal rate. These excellent photocatalytic performances were attributed to the uniform distribution of size-controlled Fe2O3/CuxO nanoparticles on the TNF surface, improved light-harvesting ability in the visible region, and remarkable charge carrier separation/transfer rate achieved through a dual-Z-scheme heterojunction mediated by an interfacial electric field.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Nanoscience & Nanotechnology
Sulakshana Shenoy, Chitiphon Chuaicham, Mariyappan Shanmugam, Takamasa Okumura, Umamahesh Balijapalli, Wei Li, Vellaichamy Balakumar, Keiko Sasaki, Karthikeyan Sekar
Summary: This study successfully synthesized Cu2O nanoparticles on TiO2 nanofibers using a solution-based technique and coated them with reduced graphene oxide to form a composite material. The composite material exhibited high photocatalytic activity for hydrogen evolution under visible light irradiation, which can be attributed to the formation of an interfacial electric field and efficient charge transfer. Experimental evidence confirmed that the formation of a heterojunction between CTNF@rGO extended the lifetimes of photogenerated charge carriers, leading to enhanced photocatalytic performance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Brahmari Honnappa, T. R. Naveen Kumar, Prince J. J. Sagayaraj, Sulakshana Shenoy, Chitiphon Chuaicham, Manova Santhosh Yesupatham, Anantharaj Sengeni, Bernaurdshaw Neppolian, Keiko Sasaki, Karthikeyan Sekar
Summary: In this article, Cu(OH)(2) with various morphology was synthesized rapidly using an anodization technique. The formation of Cu(OH)(2) was confirmed by XPS, XANES, and EXAFS techniques. Cu(OH)(2) exhibited better stability and charge transfer ability than CuO, and showed good bifunctional activity for OER and MOR.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Sulakshana Shenoy, Chitiphon Chuaicham, Keiko Sasaki, Sungkyun Park, Muthuchamy Nallal, Kang Hyun Park, Karthikeyan Sekar
Summary: A novel one-pot synthesis method was proposed for designing bimetallic oxide-nitride electrocatalysts with tunable morphologies. The method showed remarkable catalytic efficacy and stability without the need for a distinct nitridation process.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
