Article
Chemistry, Analytical
Zahra Afzali, Alireza Mohadesi, Mohammad Ali Karimi, Fariba Fathirad
Summary: A novel sensor was developed for the determination of patulin toxin using a glassy carbon electrode modified with a composite material, providing high sensitivity and accuracy.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Xin Yuan, Kwanpyung Lee, J. R. Schmidt, Kyoung-Shin Choi
Summary: This study demonstrates that halide adsorption on Cu electrode can effectively suppress the hydrogen atom transfer (HAT) reaction during the reductive upgrading of 5-hydroxymethylfurfural (HMF), leading to enhanced production of 2,5-dimethylfuran (DMF). The identity and concentration of the halide, as well as the reduction conditions, were found to affect the halide adsorption on Cu, and optimal halide coverages were identified to maximize the selectivity for DMF. Experimental and computational results provide a detailed understanding of the effects of halide adsorption at the atomic level.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Giancosimo Sanghez de Luna, Adriano Sacco, Simelys Hernandez, Francesca Ospitali, Stefania Albonetti, Giuseppe Fornasari, Patricia Benito
Summary: In this study, a highly selective electrochemical reduction of 5-hydroxymethylfurfural to 2,5-bishydroxymethylfuran was achieved using an AgCu foam electrocatalyst. The selectivity depended on the current density and reaction time, with optimal conditions resulting in high BHMF selectivity and production, albeit with co-generation of hydrogen gas.
Review
Chemistry, Multidisciplinary
Olja Simoska, Zayn Rhodes, Samali Weliwatte, Jaime R. Cabrera-Pardo, Erin M. Gaffney, Koun Lim, Shelley D. Minteer
Summary: The development of electrochemical catalytic conversion of 5-hydroxymethylfurfural (HMF) has gained attention recently, but is still in its early stages with limited practical applications due to low catalytic activity and product selectivity. Understanding catalytic processes and designing electrocatalysts are crucial for achieving selective and complete conversion.
Article
Biochemical Research Methods
Mustafa Celebier, Aysegul Dogan, Incilay Suslu, Sacide Altinoz
Summary: This study aimed to develop a square-wave stripping voltammetric method for determining roflumilast in its pharmaceutical dosage forms, and investigate the electrochemical behavior of roflumilast. The method was validated with good results in terms of linearity, sensitivity, repeatability, accuracy, precision, selectivity, recovery, robustness, and ruggedness, demonstrating its potential for routine applications in determining roflumilast content.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Food Science & Technology
Guillaume Legrand Ngolong Ngea, Qiya Yang, William Tchabo, Raffaello Castoria, Xiaoyun Zhang, Hongyin Zhang
Summary: This study isolated 11 lactic acid bacteria from apple surface, with strain LB7 showing inhibitory activity against Penicillium expansum and the ability to detoxify patulin in fruit juices. These LABs have potential application in food biocontrol and biopreservation strategies.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Chemistry, Physical
Yongfang Zhou, Yi Shen, Xuanli Luo
Summary: The study focuses on establishing a rigorous assessment protocol for the electrochemical conversion of HMF, revealing the effects of electrolyte pH, support material properties, electrolyte impurities, and other factors on HMF conversion.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Alaleh Zoghi, Kianoush Khosravi Darani, Azita Hekmatdoost
Summary: Recent research has shown that the potential of NaOH-treated Lactobacillus plantarum ATCC 8014 cells in detoxifying patulin-contaminated apple juices is significant. The stability of the LAB-patulin complex was assessed under simulated gastrointestinal conditions, showing promising results.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Chemistry, Analytical
Jianbo Liu, Jing Liu, Yonghui Shang, Jinqiong Xu, Xinyang Wang, Jianbin Zheng
Summary: A multiplex electrochemical immunosensor was developed for the simultaneous detection of two lung cancer markers, CEA and CA125, with high sensitivity and accuracy.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Lanting Qian, Abigail van Riesen, Joshua van der Zalm, Richard Manderville, Aicheng Chen
Summary: Investigations on the electrochemical behaviors of merocyanine dyes revealed their strong dependence on the type of electrode used, as well as the presence of substituent functional groups. The inclusion of these functional groups led to reduced fouling and affected electron transfer kinetics. Understanding the influence of substituents allows for the design and synthesis of aptamer-binding merocyanine dyes for highly robust and sensitive electrochemical sensors in medical and environmental applications.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Aleksandra Masulovic, Jelena D. Lovic, Jelena Ladarevic, Vesna Vitnik, Zeljko Vitnik, Milka Avramov Ivic, Dusan Mijin
Summary: In this study, the electrooxidation ability of nine pyridones was evaluated using cyclic and square-wave voltammetry in aqueous buffer solutions. The influence of pyridone structure on electrochemical activity was investigated through experimental spectra and quantum chemical calculations. The presence of -OH group at position 6 of the pyridone ring was found to determine the electrochemical activity. The most stable forms, both protonated and deprotonated, were defined using UV-Vis spectra and DFT calculations, with the deprotonated anionic form identified as the most electrochemically active. Additionally, the impact of the substituent at position 3 of the pyridone scaffold was discussed.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Mogomotsi N. Ranku, Gloria E. Uwaya, Omolola E. Fayemi
Summary: An electrochemical sensor for dopamine was designed using a SPCE-Fe3O4/SPEEK electrode, with successful synthesis of Fe3O4 nanoparticles confirmed. The sensor showed good detection limits and sensitivity for dopamine, with practical applicability demonstrated in dopamine injections.
Article
Food Science & Technology
Xia Lu, Baoshan He, Ying Liang, Jinshui Wang, Qiang Jiao, Yong Liu, Rui Guo, Min Wei, Huali Jin, Wenjie Ren, Zhiguang Suo
Summary: In this study, a dual-enzymes-driven electrochemical aptasensor was constructed for ultra-sensitive detection of patulin (PAT) in fruits. The aptasensor showed favorable selectivity, reproducibility, and long-term stability. In real sample analysis, the aptasensor demonstrated good accuracy and precision.
Review
Chemistry, Multidisciplinary
Lei Guo, Xiaoxue Zhang, Li Gan, Lun Pan, Chengxiang Shi, Zhen-Feng Huang, Xiangwen Zhang, Ji-Jun Zou
Summary: This review presents recent advances in electrochemical oxidation of 5-hydroxymethylfural (HMF), ranging from reaction mechanism to reactor design. The systematic summary of the reaction mechanism and pathway, along with the emphasis on often overlooked parameters, provides a deeper understanding of HMF electrochemical oxidation. Comprehensive reviews of electrocatalysts for different products and introductions of reactors are also included. Prospective future efforts on exploring reaction mechanism, electrocatalysts, and reactor design are discussed. This review is expected to promote the economical and efficient electrochemical conversion of biomass for industrial applications.
Article
Chemistry, Multidisciplinary
Mengxiao Sun, Yue Wang, Chunsen Sun, Yan Qi, Jia Cheng, Yumei Song, Lixue Zhang
Summary: A controllable nitrogen doping strategy is employed to enhance the catalytic activity of Co3O4 nanowires for the electro-oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) into 2,5-furandicarboxylic acid (FDCA) with high selectivity.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).