期刊
TALANTA
卷 115, 期 -, 页码 381-385出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2013.05.054
关键词
Glutathione; Nihcf/CTAB/AuNPs Pt UME; Electrochemical detection; Microsensor
资金
- National Natural Science Foundation of China [21175108, 21165015]
- Science and Technology Support Projects of Gansu Province [1011GKCA025]
A novel method for glutathione (GSH) detection in real blood sample with a nickel hexacyanoferrate (NiHCF) film modified Pt ultramicroelectrode (UME) was proposed. The electrochemical properties of NiHCF film modified Pt UME were improved by introducing cetyltrimethylammonium bromide (CTAB) and Au nanoparticles (AuNPs) into NiHCF film. The novel hybrid films (NiHCF/CTAB/AuNPs) were prepared by electrodepositing NiHCF and AuNPs in the presence of CAB on the surface of Pt UME. The results indicated that the prepared NiHCF/CTAB/AuNPs Pt UME had a sensitive respond toward the oxidation of GSH and could be used for its selective determination in the presence of other coexisting interferents in real blood samples. The calibration curve for GSH was found to be linear from 0.2-1 mu M, and the limit of detection (S/N=3) was 0.08 mu M. The strategy explored here might provide a new pathway to design NiHCF/CTAB/AuNPs film microsensor for in situ detecting GSH, which had unique characteristics and potential applications in the fields of sensor and medical diagnosis. (C) 2013 Elsevier B.V. All rights reserved.
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