期刊
TALANTA
卷 99, 期 -, 页码 247-255出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2012.05.047
关键词
Carbamazepine; Extraction; LDTD-APCI-MS/MS; Wastewater; Wastewater sludge
资金
- Natural Sciences and Engineering Research Council of Canada [355254]
- Fonds Quebecois de la Recherche sur la Nature et les Technologies (FQRNT), Quebec
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Phytronix Technologies, Quebec
In this study, the distribution of the anti-epileptic drug carbamazepine (CBZ) in wastewater (WW) and aqueous and solid phases of wastewater sludge (WWS) was carried out. A rapid and reliable method enabling high-throughput sample analysis for quicker data generation, detection, and monitoring of CBZ in WIN and WWS was developed and validated. The ultrafast method (15 s per sample) is based on the laser diode thermal desorption-atmospheric pressure chemical ionization (LDTD-APCI) coupled to tandem mass spectrometry (MS/MS). The optimization of instrumental parameters and method application for environmental analysis are presented. The performance of the novel method was evaluated by estimation of extraction recovery, linearity, precision and detection limit. The method detection limits was 12 ng L-1 in WIN and 3.4 ng g(-1) in WWS. The intra- and inter-day precisions were 8% and 11% in WW and 6% and 9% in WINS, respectively. Furthermore, three extraction methods, ultrasonic extraction (USE), microwave-assisted extraction (MAE) and accelerated solvent extraction (ASE) with three different solvent condition such as methanol, acetone and acetonitrile:ethyle acetate (5:1, v/v) were compared on the basis of procedural blank and method recovery. Overall, ASE showed the best extraction efficiency with methanol as compared to USE and MAE. Furthermore, the quantification of CBZ in WW and WINS samples showed the presence of contaminant in all stages of the treatment plant. (C) 2012 Elsevier B.V. All rights reserved.
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