期刊
TALANTA
卷 84, 期 1, 页码 235-239出版社
ELSEVIER
DOI: 10.1016/j.talanta.2010.12.026
关键词
Microfluidic; PMMA; Colourimetric assays; Absorption; Microsensors
资金
- UK Natural Environment Research Council (NERC) through National Oceanography Centre, Southampton
- UK Engineering and Physical Sciences Research Council (EPSRC) [EP/E016774/1]
- Engineering and Physical Sciences Research Council [EP/E016774/1] Funding Source: researchfish
- Natural Environment Research Council [noc010003, noc010013] Funding Source: researchfish
- EPSRC [EP/E016774/1] Funding Source: UKRI
- NERC [noc010003, noc010013] Funding Source: UKRI
We describe a novel, cost effective and simple technique for the manufacture of high sensitivity absorption cells for microfluidic analytical systems. The cells are made from tinted polymethyl methacrylate (PMMA) in which microfluidic channels are fabricated. Two windows (typically 250 urn thick, resulting in little optical power loss) are formed at either end of the channel through which light is coupled. Unwanted stray light from the emitter passes through a greater thickness of the tinted substrate (typically the length of the cell) and is preferentially absorbed. In effect, this creates a pin-hole configuration over the length of the absorption cell, providing improved performances (sensitivity. S/N ratios, baseline noise and limit of detection) when used as an absorption cell compared to clear substrates. The method is used to achieve a LOD of 20 nM with a colourimetric iron assay and a LOD of 0.22 milli-absorption units with a pH assay. (c) 2011 Elsevier B.V. All rights reserved.
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