Article
Chemistry, Analytical
Qi Wang, Huaqian Xin, Zhou Wang
Summary: A label-free immunosensor for detecting carcinoembryonic antigen (CEA) was constructed with high electron conductivity and excellent antibody fixation ability, demonstrating balanced performance with a wide linear range, low detection limit, and satisfactory selectivity, repeatability, and stability.
Article
Chemistry, Analytical
Ze Zhang, Tao Yao, Hongliang Han, Zhanfang Ma
Summary: In this study, a novel ultrasensitive electrochemical platform was developed for the detection of trace protein biomarkers. By combining electrochemistry with the silver mirror reaction, the assay achieved a zeptomolar level detection of proteins. This strategy offers a universal approach for the ultrasensitive detection of various proteins in clinical diagnostics and point-of-care testing.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Gulam Rabbani, Mohammad Ehtisham Khan, Ejaz Ahmad, Mohsin Vahid Khan, Abrar Ahmad, Anwar Ulla Khan, Wahid Ali, Mazin A. Zamzami, Abdullateef H. Bashiri, Waleed Zakri
Summary: C-reactive protein (CRP) is a biomarker that can be used for the accurate diagnosis of cardiovascular risk, type-2 diabetes, metabolic syndrome, hypertension, and various types of cancers. This study successfully developed a highly sensitive and selective carbon nanotube field-effect transistor (CNT-FET) immunosensor for detecting CRP, with a wide dynamic range, rapid response time, and low variation. The use of this immunosensor can provide a low-cost and rapid clinical detection technology for the early diagnosis of coronary heart disease (CHD) and replace traditional expensive laboratory-based procedures.
BIOELECTROCHEMISTRY
(2023)
Article
Engineering, Electrical & Electronic
Muhammadeziz Tursunniyaz, Joseph Andrews
Summary: The key to fighting global pandemics like COVID-19 is the availability of low-cost, reliable, and fast-response diagnostic tools. Electronic biosensors, particularly printed ones, offer a convenient integration with existing healthcare networks and point-of-care testing devices. This study presents a fully printed capacitive biosensor that utilizes immobilized antibodies on PVDF films to detect the SARS-CoV-2 spike protein with the assistance of gold nanoparticles. The capacitive immunoassay demonstrates potential as a screening and vaccine efficacy assessment tool for resource-limited areas.
IEEE SENSORS JOURNAL
(2023)
Review
Chemistry, Analytical
Shipeng Gao, Jose M. Guisan, Javier Rocha-Martin
Summary: This review discusses the importance of stepwise covalent conjugation in the fabrication of high-efficiency immunosensors, emphasizing the well-orientation of full-length IgGs onto the sensing platform. By combining non-covalent adsorption and covalent conjugation, IgGs can be fixed in a specific orientation, crucial for biosensing efficiency.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Applied
Subhasis Mahari, Akanksha Roberts, Sonu Gandhi
Summary: A novel electrochemical biosensor integrated with gold nanorods was used to explore the interaction between antibodies and Salmonella in this study, leading to the development of a method to detect Salmonella in meat and milk samples. The method has a long shelf life, good repeatability, and reproducibility, making it a potential alternative to conventional analytical approaches.
Article
Chemistry, Applied
Yanbo Wang, Junjie Ma, Huan Li, Jinru Zhou, Hong Zhang, Linglin Fu
Summary: A novel immunoassay for quantitation of shrimp arginine kinase (AK) was developed using gold nanoparticles and quantum dots, showing high sensitivity and specificity.
Article
Multidisciplinary Sciences
S. Reza Mahmoodi, Pengfei Xie, Daniel P. Zachs, Erik J. Peterson, Rachel S. Graham, Claire R. W. Kaiser, Hubert H. Lim, Mark G. Allen, Mehdi Javanmard
Summary: A non-faradaic label-free cortisol sensing platform was developed using a nanowell array design, allowing for rapid and low volume sensing. The sensor, built on a glass substrate, showed a good response to cortisol concentrations and compared well with results from standard ELISA. Nanowell array sensors have potential to be a promising platform for point-of-care testing.
Article
Chemistry, Physical
Ankush Medhi, Susmita Baruah, Jyoti Singh, C. A. Betty, D. Mohanta
Summary: A cost effective, label free, sensitive and selective capacitive immunosensor has been developed based on composites of conducting polymer PEDOT-PSS, graphene oxide (GO) and gold nanoparticles (AuNPs). The sensor showed high sensitivity and flexibility for various sensor applications.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Analytical
Nader Amini, Mojtaba Shamsipur, Kazhal Naderi, Afshin Maleki
Summary: The aim of this study is to develop an immunosensor with the ability to detect antigen G using a novel electrochemical approach. By covalently linking antibody molecules using carboxylic groups and 3-(trimethoxysilyl)propylamine on graphene oxide, a highly sensitive immunosensor was created with low detection limit and excellent activity at physiological pH values.
MICROCHEMICAL JOURNAL
(2022)
Article
Biophysics
Chunling Mao, Lei Wu, Yi Wen, Ximing Tang, Zheng Huang, Longshan Zhao
Summary: A photoelectrochemical immunosensor based on MIL-101(Cr) and CdTe-QDs composites was synthesized to detect the carcinoembryonic antigen (CEA) in human serum and urine samples. The sensor demonstrated altered photocurrent polarity, improved light utilization efficiency, and enhanced separation efficiency of electron-hole pairs. Under optimized conditions, the sensor showed high sensitivity and stability, with detection limits of 0.00018 ng mL-1 and 0.00023 ng mL-1 for anodic and cathodic detection of CEA, respectively.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Thu Zar Ma Ma Moe Min, Sonwit Phanabamrung, Woraphan Chaisriratanakul, Apirak Pankiew, Awirut Srisuwan, Kondee Chauyrod, Cholatip Pongskul, Chamras Promptmas, Chanvit Leelayuwat
Summary: This study demonstrates the ability of the Ion-Sensitive Field-Effect Transistor (ISFET)-based immunosensor to detect antibodies against human leukocyte antigen (HLA) and major histocompatibility complex class-I-related chain A (MICA). The modified ISFET devices with functionalized sensing membrane show excellent analytical performance for immobilizing HLA and MICA proteins. The sensitivity and specificity of the ISFET-based immunosensor make it a promising tool in the field of kidney transplantation.
Article
Chemistry, Multidisciplinary
Tianbao Dong, Chaowei Han, Meng Jiang, Tiantian Zhang, Qing Kang, Pengcheng Wang, Feimeng Zhou
Summary: The study developed a sensor that can simultaneously detect antibodies and viral particles in serum samples, providing information about viral neutralization and antibody efficacy. It has a fast analysis time and good reproducibility. Understanding the disease status and immunity is crucial for controlling the spread of the virus.
Article
Immunology
Asako Murayama, Haruka Momose, Norie Yamada, Keiji Matsubayashi, Masamichi Muramatsu, Isao Hamaguchi, Takanobu Kato
Summary: This study evaluated the performance of thirteen anti-HCV, five HCV RNA, and two HCV Ag kits using International Standards for HCV RNA and HCV Ag. All anti-HCV kits correctly diagnosed specimens in the regional reference panel, while HCV RNA kits quantified the International Standard with minimum deviation and diagnosed the reference panel specimens correctly. However, some HCV Ag kits showed inconsistent quantification of the International Standard.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biophysics
Sun Sang Kwon, Dongwoo Kim, Mijin Yun, Jeong Gon Son, Soo Hyun Lee
Summary: In this study, the sensing performance of electrolyte-gated graphene field-effect transistor sensors for detecting tau protein was improved through a simplified, linker-free antibody immobilization process. The linker-free patterned graphene sensors showed enhanced detection sensitivity and performance, particularly suitable for operation in high ionic concentration electrolytes.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Electrical & Electronic
Quang Khue Vu, Thi Hue Nguyen, Anh-Tuan Le, Ngoc Phan Vu, Xuan Dinh Ngo, Tien Khi Nguyen, Thanh Thuy Nguyen, Chung Van Pham, Thi Luyen Nguyen, Thanh Le Thi Dang, Matteo Tonezzer, Quang Huy Tran
Summary: This paper presents a reliable solution to enhance the electron transfer and stability of screen-printed carbon electrodes (SPCEs) for the direct detection of pathogenic bacteria. By modifying the SPCEs with a nanocomposite of silver nanoparticles (AgNPs) and reduced graphene oxide (rGO), the peak current was increased and the charge transfer resistance was decreased. The modified electrodes could detect Salmonella bacteria directly with a low limit of detection (LoD) of 22 CFU/mL.
JOURNAL OF ELECTRONIC MATERIALS
(2022)
Article
Engineering, Electrical & Electronic
Nguyen Thi Hue, Tuyet Nhung Pham, Ngo Xuan Dinh, Hoang Van Tuan, Nguyen Thi Thu Thuy, Man Hoai Nam, Vu Dinh Lam, Anh-Tuan Le, Tran Quang Huy
Summary: Gold nanoparticles (AuNPs) with a diameter range of 10-20 nm were synthesized and used to modify the working electrode surface of screen-printed carbon electrodes (SPCEs) and screen-printed platinum electrodes (SPPtEs) for the direct detection of chloramphenicol (CAP). The modified electrodes showed significantly enhanced electrochemical performance, especially Au/SPCEs, which exhibited improved conductivity, electrochemically active area, and stability compared to Au/SPPtE. The use of AuNPs to modify SPCEs is a promising approach to enhance the direct detection of CAP.
JOURNAL OF ELECTRONIC MATERIALS
(2022)
Article
Engineering, Electrical & Electronic
Mai Quan Doan, Nguyen Ha Anh, Nguyen Xuan Quang, Ngo Xuan Dinh, Doan Quang Tri, Tran Quang Huy, Anh-Tuan Le
Summary: An electrochemical approach was used to green synthesize gold and silver nanoparticles with high levels of purity and scalability, which were then deposited on aluminum substrates for SERS-based detection of Methylene Blue. The noble-metal nanoparticles exhibited outstanding sensing performance for MB detection with high enhancement factors.
JOURNAL OF ELECTRONIC MATERIALS
(2022)
Article
Chemistry, Physical
Nguyen Ha Anh, Mai Quan Doan, Ngo Xuan Dinh, Tran Quang Huy, Doan Quang Tri, Anh-Tuan Le
Summary: Electrochemically synthesized gold nanoparticles were used to fabricate surface enhanced Raman spectroscopy sensors for monitoring thiram and CAP in food samples. The SERS performance of the sensors was closely associated with the molecular structure of the analytes, and the adsorption abilities of the analytes on the nanoparticles surface and in the nano-gaps were studied. Thiram showed better adsorption ability than CAP due to its sulfur-containing structure and smaller steric hindrance.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Physical
Quan Doan Mai, Ha Anh Nguyen, Thi Lan Huong Phung, Ngo Xuan Dinh, Quang Huy Tran, Tri Quang Doan, Anh-Tuan Le
Summary: This study investigates the influence of energy levels and alignments of molecular orbitals on the charge transfer process and surface-enhanced Raman scattering (SERS) phenomenon. Experimental results show that the detection of antibiotics on electrochemically synthesized colloidal silver nanoparticles (e-AgNPs) as substrates differs due to the different energy levels of the antibiotics. The hypothesis is confirmed by testing other organic compounds. The study reveals a clear correlation between the energy level of analytes and their SERS signals.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Electrochemistry
Tuyet Nhung Pham, Xuan Nui Pham, Hoa Thi Nguyen, Thanh Pham, Quang Huy Tran, Anh-Tuan Le
Summary: MIL-53(Fe), MIL-101(Cr), and MIL-53(A1) were successfully prepared and selected as promising modifying materials on electrode surface for chloramphenicol (CAP) detection. Among them, MIL-101(Cr)/SPE and MIL-53(Fe)/SPE exhibited excellent electrochemical performance, while MIL-53(Al)/SPE showed poor performance due to weak electron conductivity and lack of electrocatalytic active sites. Further optimization of the conductivity and adsorption capacity balance in MIL materials is needed for electrochemical sensors.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Polymer Science
Thuy Thi Thu Nguyen, Huu The Nguyen, Hai Thi Trinh, Trang Thi Thu Bui, Anh-Tuan Le, Tran Quang Huy
Summary: In this study, the adsorption capacity of electrospun PVDF/GO membranes for Pb2+ was compared. The results showed that the adsorption performance increased with higher GO contents. The diameter of the electrospun PVDF/GO fibers did not significantly affect the adsorption capacity. The addition of PEG improved the hydrophilicity of the fibers and increased the Pb2+ adsorption. The adsorption behavior was influenced by contact time and pH. The PVDF/GO/PEG membranes maintained a high Pb2+ removal rate after six adsorption-desorption cycles.
MACROMOLECULAR RESEARCH
(2022)
Article
Metallurgy & Metallurgical Engineering
Nguyen Trong Hung, Le Ba Thuan, Tran Chi Thanh, Nguyen Thanh Thuy, Doan Thi Thu Tra, Khoai Do Van, Masayuki Watanabe, Pham Quang Minh, Hoang Sy Than, Nguyen Duc Vuong, Dinh Van Phuc, Jin-Young Lee, Jong Hyuk Jeon, Rajesh Kumar Jyothi
Summary: This study systematically investigated a continuous counter-current extraction method for the selective recovery of thorium and uranium from rare earth concentrate leach solutions in Vietnam. Using primary amine N1923 as the extractant, thorium and uranium were efficiently recovered through continuous mixer-settler extraction, scrubbing, and back-extraction steps.
Article
Nanoscience & Nanotechnology
Hue Thi Nguyen, Tuyet Nhung Pham, Anh-Tuan Le, Nguyen Thanh Thuy, Tran Quang Huy, Thuy Thi Thu Nguyen
Summary: This study prepared nanoformulation of berberine to enhance its solubility and improve its antibacterial effectiveness against hospital-acquired infections. The prepared BBR nanoparticles showed a narrow size distribution and significantly enhanced antibacterial activity compared to pure BBR at the same concentration.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Quan Doan Mai, Ha Anh Nguyen, Ngo Xuan Dinh, Nguyen Thi Thu Thuy, Quang Huy Tran, Pham Cong Thanh, Anh-Tuan Pham, Anh-Tuan Le
Summary: In-paper flexible SERS chips were prepared by immersing filter paper into e-AgNP solution and drying naturally at room temperature. The chips allowed for two sample collecting approaches, the dip and dry method for soluble target analytes and the paste and peel off procedure for analytes on surfaces. These chips were used for in-situ detection of methylene blue dye in river water and thiram pesticide on apple skin, with detection limits of 10-10 M and excellent recovery rates. The simple procedures and versatility of the e-AgNPs-based in-paper SERS chips bring SERS techniques closer to real applications.
Article
Chemistry, Medicinal
Nguyen Thi Thu Thuy, Hoang Thi Minh Hien, Nguyen Cam Ha, Le Thi Thom, Dang Diem Hong, Nguyen Van Thinh, Nguyen Trong Dan, Nguyen Dang Hoi, Vu Thi Loan, Hoang Duc Quang, Dan Thi Thuy Hang, Phan Van Kiem, Nguyen Tien Dat, Nguyen Xuan Nhiem
Summary: This study isolated and identified 17 compounds from the methanol extract of the marine microalga Thraustochytrium pachydermum TSL10, and evaluated their antimicrobial activities. It was found that the newly discovered sterol (24R)-ergosta-7,22-diene-3 beta,5 alpha,9 alpha-triol exhibited significant antimicrobial activity.
NATURAL PRODUCT COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Hue Thi Nguyen, Tuyet Nhung Pham, Le Thi Le, Tien Khi Nguyen, Anh-Tuan Le, Tran Quang Huy, Thuy Thi Thu Nguyen
Summary: This study introduces the bioformulations of Ag/BBR and ZnO/BBR complexes against pathogenic bacteria in the gastrointestinal tract. The presence of BBR significantly influenced the nanoparticle growth, resulting in the formation of core/shell structured Ag/BBR and ZnO/BBR NPs with small particle sizes. The antibacterial test showed that BBR, Ag, or ZnO components all contributed to the increase of antibacterial ability of Ag/BBR and ZnO/BBR NPs against both methicillin-resistant Staphylococcus aureus (MRSA) and Salmonella enteritidis (S. enteritidis).
Proceedings Paper
Engineering, Environmental
Pham Viet Hai, Nguyen Thi Diem Thuy, Phan Thi Thanh Hang, Dao Nguyen Khoi
Summary: This study assessed the level of sustainable development in the Ly Son and Phu Quy island districts of Vietnam using the sustainable development index (SDI). The results showed that the two districts had similar levels of sustainable development, but there is room for improvement in certain indicators such as sex ratio at birth, employment ratios, and forestland area. To increase sustainable development, local managers should focus on improving poverty reduction policies and ensuring social security.
ADVANCES IN RESEARCH ON WATER RESOURCES AND ENVIRONMENTAL SYSTEMS
(2023)
Article
Chemistry, Multidisciplinary
Dao Thi Nguyet Nga, Nguyen Le Nhat Trang, Van-Tuan Hoang, Xuan-Dinh Ngo, Pham Tuyet Nhung, Doan Quang Tri, Nguyen Duy Cuong, Pham Anh Tuan, Tran Quang Huy, Anh-Tuan Le
Summary: This study explored the use of electrochemically exfoliated graphene oxide (GO)-modified screen-printed carbon electrodes for the detection of the nitrofuran antibiotic furazolidone (FZD). By designing GO samples with different oxygen functional group content/defect density, the researchers observed significant changes in the kinetic parameters of electron transfer reactions, leading to improved electrochemical response for FZD detection. The proposed electrochemical nanosensor showed promising applications in food-producing animal safety monitoring.
Review
Chemistry, Multidisciplinary
Nguyen Ha Anh, Mai Quan Doan, Ngo Xuan Dinh, Tran Quang Huy, Doan Quang Tri, Le Thi Ngoc Loan, Bui Van Hao, Anh-Tuan Le
Summary: Modern society is facing serious health problems, such as food safety, diseases and illness. Therefore, it is urgent to develop analysis methods for the detection and control of food contaminants, disease biomarkers, and pathogens. Gold nanoparticles (AuNPs) have emerged as promising transducers for optical sensing systems due to their simple preparation, high surface-to-volume ratio, excellent biocompatibility, and unique optical properties. This review provides an overview of the synthesis of AuNPs and their optical properties, as well as the recent advances in the development of AuNP-based optical nanosensors for monitoring food contaminants, disease biomarkers, and pathogens. The challenges and future directions in the application of these nanosensors are also discussed.
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
