期刊
TALANTA
卷 81, 期 1-2, 页码 187-196出版社
ELSEVIER
DOI: 10.1016/j.talanta.2009.11.055
关键词
Enantioselectivity; Molecularly imprinted polymer-carbon; composite; Fiber sensor; Differential pulse anodic stripping; voltammetry; L- and D-Tryptophan
资金
- Council of Scientific and Industrial Research, New Delhi
- Department of Science and Technology [SR/S1/1C-18/2006]
Electrochemical sensors demonstrating enantioselectivity to tryptophan enantiomers, with high selectivity and sensitivity, were fabricated by the use of a monolithic fiber of molecularly imprinted polymer-carbon composite. The recognition mechanism and performance of these sensors were evaluated by differential pulse anodic stripping voltammetry. The sensor imprinted for L-tryptophan not only discriminated the target from its analogues and other amino acids but also responded specifically in racemic mixture in aqueous, biological, and pharmaceutical samples. The binding kinetics of L-tryptophan was also established with the help of anodic stripping cyclic voltammetry and chronocoulometry. The detection limit for L-tryptophan was as low as 0.24 ng mL(-1) (signal/noise = 3) which is appropriate for biomarking diseases, caused by an acute tryptophan-depletion, in clinical setting. (c) 2009 Elsevier B.V. All rights reserved.
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