Article
Biophysics
Yuanyuan Wang, Dexiang Feng, Xianwen Kan
Summary: In this study, a facile strategy for the design of highly efficient electrochemiluminescence (ECL) sensor was proposed for the sensitive and accurate detection of prostate-specific antigen (PSA). The integration of carboxylated graphitic carbon nitride (g-C3N4) nanosheet (CCN) and tris (2, 2'-Bipyridyl) ruthenium (II) (Ru(bpy)32+) encapsulated in silica nanospheres (RuSi NPs) allowed for a shortened electron-transfer path and increased resonance energy transfer (RET) efficiency. The ECL signal was remarkably decreased through the introduction of aptamer, PSA, and ferroceneboronic acid (FcBA), enabling the ultrasensitive detection of PSA with high selectivity.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Hui Dong, Zhanglei Wu, Shanghua Liu, Yueyuan Li, Feng Jiang, Qing Liu, Ping Wang, Zhen Xu, Yueyun Li
Summary: A signal-off Electrochemiluminescence (ECL) biosensing platform based on Glutathione-Au nanoclusters covered reduced graphene oxide (GSH-Au NCs@rGO) and Au nanoparticles functionalized copper oxide (Au@CuO) was fabricated. The proposed platform enables high sensitivity and intensity for detecting biomarkers in early clinical diagnosis of diseases.
Article
Chemistry, Multidisciplinary
Xiuling Chu, Desong Zhu, Min Liu, Lingrang Kong, Shiyun Ai
Summary: In this study, a scissor double fluorescent triple helix molecular switch based on triple helix DNA was developed for the ultrasensitive biosensing of Bt transgene. The nanosensor showed high sensitivity, generality in design, and simplicity in operation.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yijie Wu, Zhaode Mu, Feng Gong, Min Qing, Jing Zhou, Keyu Chen, Lijuan Bai
Summary: This paper reports a high-efficiency luminescent material, which exhibits improved emission efficiency when hybridized with other substances, and applies it to the diagnosis of non-small-cell lung cancer. By anchoring the material in an ordered structure, the disadvantages of poor luminescence are eliminated.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Analytical
Juan Lu, Xiangyu Shan, Qian Wu, Zhuo Sun, Xin Zhang, Yingjie Zhao, Li Tian
Summary: A novel solid-state electrochemiluminescence (ECL) sensor for CPF detection was constructed using ZIF-67 NFs. The modified electrode exhibited stable and obvious ECL signal, with a detection limit of 3.3 x 10(-14) M.
Article
Chemistry, Multidisciplinary
An-Yi Chang, Samar S. Sandhu, P. U. Ashvin I. Fernando, Gilbert. K. Kosgei, Caitlin Bresnahan, Jared S. Cobb, Jose F. Morales, Jiachi Zhou, Shichao Ding, Ashley Hanna, Johanna Jernberg, Joseph Wang
Summary: This study reports a new di-boronic acid-functionalized ferrocene (FDBA) molecular receptor for noncovalent F- recognition, which is used to develop a solid-state miniaturized voltammetric fluoride sensor capable of direct and reversible F- detection in drinking water and community water. The sensing mechanism is based on the conformational change of FDBA facilitated by the unique linkage of two electron-accepting phenylboronic acid moieties with the electron-donating ferrocene moiety. The performance of the sensor is compared to traditional potentiometric F-ISEs, showing significant advantages.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Qingyue Han, Suqing Wang, Wenhao Ren, Fangdan Zhang, Zhanbo Tang, Ju Wang, Haihui Wang
Summary: Poly (ethylene oxide) (PEO)-based electrolytes are widely studied for their safety, low cost, and easy scalability. However, poor ionic conductivity, slow reaction kinetics, and uneven lithium deposition hinder their practical use. This study introduces ferrocene (Fc) as a redox mediator filler in PEO-based electrolytes to improve the performance of all-solid-state Li-metal batteries. Fc enhances the ionic conductivity and regulates lithium flux over the Li metal, preventing dendrite growth. It also accelerates the electron transfer and reaction kinetics of the LiFePO4 cathode. The resulting all-solid-state LiFePO4/PEO electrolyte/Li battery with Fc addition exhibits excellent cycling stability, with a high capacity retention of 92.5% after 300 cycles.
JOURNAL OF POWER SOURCES
(2023)
Article
Multidisciplinary Sciences
Chikkili Venkateswara Raju, Shanmugam Senthil Kumar
Summary: The development of a self-enhanced solid-state ECL platform using polyluminol gold nanocomposite on a glassy carbon electrode has shown promising potential for sensitive and selective detection of Hg2+ ions. The presence of gold nanoparticles enhances electron transfer kinetics, leading to improved ECL intensity and label-free detection. This platform could pave the way for on-site monitoring in clinical bioassays and immunosensors.
SCIENTIFIC REPORTS
(2021)
Article
Spectroscopy
Megha, Paramjit Kaur, Kamaljit Singh
Summary: This study presents the stimuli modulated fluorescence properties of an imidazole-based molecular probe in the solid state. The probe displayed aggregation induced emission activity and intense solid-state fluorescence emission, as well as repetitive cycles of reversible mechanochromism and acidochromism. The solid-state emission was attributed to intermolecular interactions in the highly twisted conformation of the probe.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Review
Chemistry, Inorganic & Nuclear
Wenjun Xu, Fanhao Zeng, Qiurui Han, Zhili Peng
Summary: In this review, recent developments in the preparation and application of solid-state emissive carbon dots are summarized and discussed. The advantages, challenges, and prospects of solid-state emissive carbon dots are also proposed.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Analytical
Fanyong Yan, Chunhui Yi, Jingru Sun, Yueyan Zang, Yao Wang, Ming Xu, Jinxia Xu
Summary: Traditional CDs suffer from aggregation-induced quenching, limiting the preparation and luminescence performance of SCDs. Current research aims to address this issue. SCDs have broad application prospects in luminescent devices, anti-counterfeiting, and detection fields.
Article
Chemistry, Physical
Zhe Hu, Hanqing Dai, Wenjie Zhou, Jinxin Wei, Hongbin Zhang, Zhaoqi Ye, Yi Qiu, Yuanyuan Chen, Zhongtao Duan, Jing Wang, Wanlu Zhang, Fengxian Xie, Ruiqian Guo
Summary: A corrosion resistant solid-state CDs@Silicalite-1 (CDs@S-1) composite with high photoluminescence quantum yield and exceptional stability in various organic solvents and pH conditions was successfully synthesized. The composite shows great potential as a fluorescent label for various substrates and has promising applications in forensic science for latent fingerprints detection.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Electrochemistry
Huanhuan Xing, Hongyin Xia, Yongchao Fan, Yuan Xue, Chao Peng, Jiangtao Ren, Jing Li, Erkang Wang
Summary: Highly conductive MXene-Ti3C2 was employed as nanocarriers to anchor ECL luminophore Ru(bpy)(3)(2+), forming Ti3C2-Ru composite within seconds. The solid-state ECL platform was constructed with the assistance of Nafion, providing good electron transfer capacity and stable loading of Ru(bpy)(3)(2+) for bioanalysis.
Article
Spectroscopy
Slim Elleuch, Houcine Ammar, Younes Abid
Summary: The solid state photophysical properties of a symmetrical biscoumarin material were studied through optical spectroscopy and theoretical calculations. The biscoumarin exhibited bicomponent UV-Visible absorption with Intramolecular Charge Transfer (ICT), and showed bright blue-green emission with a large stokes shift. The research suggests potential for optoelectronic applications due to its good optical properties and emission stability.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Yue Li, Zhifang Ding, Ying Bao, Kexin Han, Guixin Li
Summary: A signal-off electrochemiluminescence (ECL) biosensor was developed for the specific sequence of BCR/ABL gene related to chronic myelogenous leukemia based on a mesoporous gold nanoparticle (AuNP)-luminol-silica nanocomposite. The detection method relies on the linear relationship between the reduced ECL intensity and the concentration of the target DNA, with a detection limit of 4.6 x 10(-16) mol/L.
ANALYTICAL LETTERS
(2022)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).