Review
Biotechnology & Applied Microbiology
Xianchao Jiang, Zhen Du, Xinran Zhang, Fakhar Zaman, Zihao Song, Yuepeng Guan, Tengfei Yu, Yaqin Huang
Summary: Drug delivery nanosystems (DDnS) using gelatin as a biomaterial have been widely developed. Gelatin, with its hydrophilic and amphoteric properties, can effectively enhance the utilization of anticancer drugs and minimize side effects. The versatility of gelatin allows for crosslinking and further modifications, making it suitable for various requirements of DDnS. This review focuses on the properties of gelatin and their correlation with anticancer DDnS, as well as the applications of gelatin-based DDnS in cancer treatments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Imran Deen, Gurpreet Singh Selopal, Zhiming M. Wang, Federico Rosei
Summary: Coatings with bioactive and biodegradable properties were fabricated using electrophoretic deposition with composite collagen, chitosan, and copper-doped phosphate glass. Variations in the coating composition were achieved by altering the concentrations of collagen and chitosan in the solutions, as well as by depositing phosphate glass with different levels of copper dopant. The ability to deposit these polymer-phosphate glass coatings offers potential for tailored orthopaedic implants with enhanced bioactivity and reduced risk of rejection.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Andrii Fedorchuk, Alain Walcarius, Magdalena Laskowska, Neus Vila, Pawel Kowalczyk, Krzysztof Cpalka, Lukasz Laskowski
Summary: A chemical procedure was developed to prepare highly ordered and vertically aligned mesoporous silica films containing selected contents of silver ions. The functionalization level can be finely tuned by controlling the co-condensation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physics, Multidisciplinary
Changhang Huang, Yanyan Zhu, Xingkun Man
Summary: Block copolymers (BCPs) are a special type of polymeric system with chemically distinct homopolymer blocks tethered together, used in bulk and thin film forms for nanotechnology applications. Progress in tailoring mesoscopic and nanoscopic structures of BCP thin films using external fields relies on precise control of structural orientation, local alignment, and long-range ordering, with conventional polymer field theory and numerical solution schemes playing a key role. Experimental and theoretical insights into the next generation of strategies for obtaining desired BCP thin film patterns and their industrial applications are also provided.
PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS
(2021)
Article
Polymer Science
Aleksandra A. A. Patlay, Andrei S. S. Belousov, Vladimir E. E. Silant'ev, Roman A. A. Shatilov, Mikhail E. E. Shmelev, Valeri V. V. Kovalev, Irina V. V. Perminova, Ivan N. N. Baklanov, Vadim V. V. Kumeiko
Summary: We developed films and nanoparticles based on low-esterified pectin hydrogel for drug delivery systems in adjuvant anticancer therapy. These nanostructured biomaterials showed tunable properties and good biocompatibility, and exhibited potential antitumor activity against human glioblastoma cells.
Article
Polymer Science
Beatriz Cotting Rossignatti, Amanda Portes Vieira, Martin Schwellberger Barbosa, Luis Miguel Gomes Abegao, Hugo Jose Nogueira Pedroza Dias Mello
Summary: This study explores the relationship between the composition of nanocomposites and the sensitivity and linearity of electrochemical pH sensors. The study found that the ECS sensitivity of PANI/CeO2 increased by 213% compared to metal oxide, and the ECS linearity of PANI/WO3 increased by 64% compared to polymeric sensitivity. This study provides important evidence for the application of nanocomposite thin films of PANI with metal oxides in electrochemical sensors.
Review
Chemistry, Multidisciplinary
Raphael Lamare, Romain Ruppert, Corinne Boudon, Laurent Ruhlmann, Jean Weiss
Summary: This review discusses the combination of porphyrins and polyoxometalates, highlighting the challenges faced in optimizing hybrid materials for applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Selvakumari Ulagesan, Madhappan Santhamoorthy, Thi Phan Vy Phan, Krishnapandi Alagumalai, Kokila Thirupathi, Seong-Cheol Kim, Taek-Jeong Nam, Youn-Hee Choi
Summary: In this study, a mesoporous silica material containing amidoxime ligand groups was successfully synthesized through surface modification. The resulting SBA-15@AMI NPs exhibited a high concentration of amidoxime ligands on the surface, making them suitable for pH-responsive drug delivery applications in cancer therapy.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Engineering, Biomedical
Yu Zhang, Pan He, Peng Zhang, Xuan Yi, Chunsheng Xiao, Xuesi Chen
Summary: Polypeptides are important biodegradable polymers widely used in drug delivery for cancer treatment. Conjugating anticancer drugs with polypeptides offers advantages in improving pharmacokinetics, enhancing targeting, and controlling drug release, contributing to enhanced therapeutic outcomes with reduced side effects.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Isha Bhorkar, Abhishek S. Dhoble
Summary: This study examined the crucial advancements in the synthesis and functionalization of self-assembling biomaterials for biomedical applications, presenting the vast potential in basic and applied research as well as the exponential growth in tools and techniques for developing and controlling self-assembled biomaterials. The study also highlighted the differences in pace of new developments for different types of biomolecular materials and emphasized self-assembly as a potent tool for the synthesis of functional biomaterials.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Inho Song, Liyan You, Ke Chen, Won-June Lee, Jianguo Mei
Summary: Homogeneous chiral electrochromics using chiral assembly of conjugated polymers have been developed through a transient solidification process with molecular chiral templates. The circular dichroism can be tuned by adjusting the doping level of the electrochemically active polymer films. The differential circularly polarized transmission in the chiral see-through display can make a well-resolved color change, demonstrating proof-of-concept devices for information encryption.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Satoshi Kodama, Yoshiaki Miyamoto, Shun Itoh, Takashi Miyata, Hiroaki Wada, Kazuyuki Kuroda, Atsushi Shimojima
Summary: In this study, self-healing silsesquioxane thin films were designed by the self-assembly process, showing efficient spontaneous and rapid crack healing. These films demonstrated significantly enhanced crack-healing ability, hardness, and adhesion compared to conventional silica-based films, due to the higher flexibility and swelling ratio of the silsesquioxane networks, as well as the interlamellar cross-linking with a long bridging organic group. These results will contribute to the practical applications of self-healing silsesquioxane materials.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Applied
Pritiranjan Mondal, Kaushik Chatterjee
Summary: The researchers developed a polysaccharide-based double network hydrogel with excellent thixotropic and self-healing properties, as well as high compressive fracture strength. Encapsulated cells remained viable within the hydrogel and released drugs effectively killed cancer cells or inhibited bacterial growth. This work demonstrates the potential of using the hydrogel as a minimally-invasive platform for drug and cell delivery.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Muhammad Asif Javaid, Sobia Jabeen, Noureen Arshad, Khalid Mahmood Zia, Muhammad Tahir Hussain, Inam Ullah, Saliha Ahmad, Muhammad Shoaib
Summary: In this study, chitosan and amylopectin blends were used to engineer poly-urethanes for sustained drug release systems. The synthesis of polyurethanes was monitored using spectroscopic techniques and the molecular weights of the prepared polymers were measured. The thermal degradation behavior of the samples was also recorded. Polyurethane prepared with equimolar blends of chitosan and amylopectin showed minimum release of the drug compared to pristine chitosan and amylopectin based poly-urethanes.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Polymer Science
Sherif Madkour, Marcel Gawek, Andreas Hertwig, Andreas Schoenhals
Summary: The thermodynamic behavior of thin PVME films with an irreversible adsorbed layer on the substrate was studied. Various techniques, including leaching, AFM, ellipsometry, and dielectric spectroscopy, were used to investigate growth kinetics, critical film thickness, influence on glass transition temperature, and molecular dynamics of the adsorbed layer. The study revealed strong percolation effects of the adsorbed layer on thin films.
Article
Multidisciplinary Sciences
Martin Olsen, Renyun Zhang, Jonas Ortegren, Henrik Andersson, Ya Yang, Hakan Olin
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Analytical
Renyun Zhang, Magnus Hummelgard, Joel Ljunggren, Hakan Olin
Article
Chemistry, Physical
Renyun Zhang, Magnus Hummelgard, Jonas Ortegren, Ya Yang, Henrik Andersson, Enkeleda Balliu, Nicklas Blomquist, Magnus Engholm, Martin Olsen, Zhong Lin Wang, Hakan Olin
Article
Physics, Applied
Weichao Wang, Jiawei Zhang, Yaju Zhang, Fangqi Chen, Heyi Wang, Mengjun Wu, Hui Li, Quanyong Zhu, Haiwu Zheng, Renyun Zhang
APPLIED PHYSICS LETTERS
(2020)
Article
Chemistry, Multidisciplinary
Renyun Zhang, Christina Dahlstrom, Haiyang Zou, Julia Jonzon, Magnus Hummelgard, Jonas Ortegren, Nicklas Blomquist, Ya Yang, Henrik Andersson, Martin Olsen, Magnus Norgren, Hakan Olin, Zhong Lin Wang
ADVANCED MATERIALS
(2020)
Review
Chemistry, Physical
Renyun Zhang, Magnus Hummelgard, Jonas Ortegren, Martin Olsen, Henrik Andersson, Ya Yang, Haiwu Zheng, Hakan Olin
Summary: Triboelectrification, first mentioned in a dialogue by Plato around 400 B.C., describes the attraction between amber and dry hair worn by people. While initially discovered on the human body, most research on triboelectrification now focuses on materials like polymers. The invention of triboelectric nanogenerators has led to increased interest in the human body's triboelectricity in both fundamental and applied research.
Review
Nanoscience & Nanotechnology
Renyun Zhang, Jonas Ortegren, Magnus Hummelgard, Martin Olsen, Henrik Andersson, Hakan Olin
Summary: This article emphasizes the importance of material development, particularly composite materials, in studying triboelectric nanogenerators. Composite materials exhibit new properties, such as dielectric performance, mechanical strength, and charge affinities, which contribute to enhancing the performance of triboelectric nanogenerators.
Article
Chemistry, Physical
Renyun Zhang, Magnus Hummelgard, Jonas Ortegren, Min Song, Martin Olsen, Henrik Andersson, Nicklas Blomquist, Hakan Olin
Summary: This article discusses the hetero-triboelectric effects of half-cell plant skins and introduces the applications of single-material TENGs fabricated using these plant skins, including energy harvesting, gas sensing, and humidity sensing.
Review
Nanoscience & Nanotechnology
Renyun Zhang, Hakan Olin
Summary: Triboelectric nanogenerators (TENGs) that utilize triboelectrification and electrostatic induction to convert mechanical energy to electricity have attracted increasing interest in the last 10 years. Organic polymers are mainly used as triboelectric materials in TENGs, but the application of inorganic nanomaterials has also been intensively studied due to their unique properties that can improve TENG performance. A review on how inorganic nanomaterials are utilized in TENGs provides insight into the progress in this area.
ACS NANOSCIENCE AU
(2021)
Review
Chemistry, Multidisciplinary
Bangsen Ouyang, Yuanhao Wang, Renyun Zhang, Hakan Olin, Ya Yang
Summary: Photoelectric devices converting light information into electrical signals are widely studied with various mechanisms like photovoltaic, photothermoelectric, and photoelectrochemical effects. The polarity of the photocurrent is sensitive to multiple parameters, impacting their design and potential applications. Recent developments focus on working mechanisms, polarity control strategies, and potential applications in biosensing and wavelength discrimination.
CELL REPORTS PHYSICAL SCIENCE
(2021)
Review
Chemistry, Physical
Renyun Zhang, Hakan Olin
Review
Chemistry, Physical
Yiding Song, Nan Wang, Yuanhao Wang, Renyun Zhang, Hakan Olin, Ya Yang
ADVANCED ENERGY MATERIALS
(2020)
Article
Engineering, Electrical & Electronic
Henrik Andersson, Pavol Suly, Goeran Thungstroem, Magnus Engholm, Renyun Zhang, Jan Maslik, Hakan Olin
JOURNAL OF LOW POWER ELECTRONICS AND APPLICATIONS
(2019)
Article
Chemistry, Physical
Renyun Zhang, Magnus Hummelgard, Jonas Ortegren, Martin Olsen, Henrik Andersson, Ya Yang, Haken Olin
ACS APPLIED ENERGY MATERIALS
(2018)
Article
Chemistry, Physical
Renyun Zhang, Magnus Engholm, Magnus Hummelgard, Henrik Andersson, Jonas Ortegren, Hakan Olin
ACS APPLIED ENERGY MATERIALS
(2018)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
