Advances in aluminum hydroxide-based adjuvant research and its mechanism

CpG/Poly (I:C) mixed adjuvant priming enhances the immunogenicity of a DNA vaccine against eastern equine encephalitis virus in mice

(2014) JinZhu Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Engineering an Effective Immune Adjuvant by Designed Control of Shape and Crystallinity of Aluminum Oxyhydroxide Nanoparticles

(2013) Bingbing Sun et al.   ACS Nano

Particulate Adjuvant and Innate Immunity: Past Achievements, Present Findings, and Future Prospects

(2013) Etsushi Kuroda et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Coadministration of Polyinosinic:Polycytidylic Acid and Immunostimulatory Complexes Modifies Antigen Processing in Dendritic Cell Subsets and Enhances HIV Gag-Specific T Cell Immunity

(2013) K. M. Quinn et al.   JOURNAL OF IMMUNOLOGY

Th1 immune responses can be modulated by varying dimethyldioctadecylammonium and distearoyl-sn-glycero-3-phosphocholine content in liposomal adjuvants

(2013) Mohammed Jubair Hussain et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

(2013) A. de Titta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucosal application of cationic poly(d,l-lactide-co-glycolide) microparticles as carriers of DNA vaccine and adjuvants to protect chickens against infectious bursal disease

(2013) Tamiru Negash et al.   VACCINE

Mechanism of Immunopotentiation and Safety of Aluminum Adjuvants

(2013) Harm HogenEsch   Frontiers in Immunology

Responses to multiple injections with alum alone compared to injections with alum adsorbed to proteins in mice

(2012) Xuan-Yi Wang et al.   IMMUNOLOGY LETTERS

Targeting tumor antigens to dendritic cells using particulate carriers

(2012) Medha D. Joshi et al.   JOURNAL OF CONTROLLED RELEASE

Adjuvants and inactivated polio vaccine: A systematic review

(2012) Jennifer Hawken et al.   VACCINE

Antigen depot is not required for alum adjuvanticity

(2011) Sharon Hutchison et al.   FASEB JOURNAL

Getting Closer to the Dirty Little Secret

(2011) Karin Pelka et al.   IMMUNITY

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

(2011) Etsushi Kuroda et al.   IMMUNITY

An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma

(2011) Mirjam Kool et al.   IMMUNITY

Chitosan Nanoparticles Act as an Adjuvant to Promote both Th1 and Th2 Immune Responses Induced by Ovalbumin in Mice

(2011) Zheng-Shun Wen et al.   Marine Drugs

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

The effect of adjuvants on the immune response induced by a DBL4ɛ-ID4 VAR2CSA based Plasmodium falciparum vaccine against placental malaria

(2011) V.V. Pinto et al.   VACCINE

Macrophagic Myofaciitis a Vaccine (alum) Autoimmune-Related Disease

(2010) Eitan Israeli et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

New adjuvants for human vaccines

(2010) M Lamine Mbow et al.   CURRENT OPINION IN IMMUNOLOGY

Characterization of the freeze sensitivity of a hepatitis B vaccine

(2010) Dexiang Chen et al.   Human vaccines & immunotherapeutics

H5N1 Influenza Vaccine Formulated with AS03A Induces Strong Cross-Reactive and Polyfunctional CD4 T-Cell Responses

(2010) Philippe Moris et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Evaluation of the intramuscular administration of Cervarix™ vaccine on fertility, pre- and post-natal development in rats

(2010) Lawrence Segal et al.   REPRODUCTIVE TOXICOLOGY

The immunobiology of aluminium adjuvants: how do they really work?

(2010) Christopher Exley et al.   TRENDS IN IMMUNOLOGY

Mechanism of action of clinically approved adjuvants

(2009) Bart N Lambrecht et al.   CURRENT OPINION IN IMMUNOLOGY

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

MF59®-Adjuvanted H5N1 Vaccine Induces Immunologic Memory and Heterotypic Antibody Responses in Non-Elderly and Elderly Adults

(2009) Angelika Banzhoff et al.   PLoS One

Mechanism of action of licensed vaccine adjuvants

(2009) Elaine Tritto et al.   VACCINE

Safety and immunogenicity of a new hepatitis B vaccine for the protection of patients with renal insufficiency including pre-haemodialysis and haemodialysis patients

(2008) Jiri Beran   EXPERT OPINION ON BIOLOGICAL THERAPY

AS04-adjuvanted human papillomavirus-16/18 vaccination: recent advances in cervical cancer prevention

(2008) Tino F Schwarz   Expert Review of Vaccines

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine

(2008) Amber Clausi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome

(2008) Christopher Exley et al.   MEDICAL HYPOTHESES

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice

(2008) Andreas Wack et al.   VACCINE

Cross-protection by MF59™-adjuvanted influenza vaccine: Neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses

(2008) Filippo Ansaldi et al.   VACCINE

Development of a freeze-stable formulation for vaccines containing aluminum salt adjuvants

(2008) LaToya Jones Braun et al.   VACCINE