Article
Biochemistry & Molecular Biology
D. V. Estrada-Osorio, Ricardo A. Escalona-Villalpando, L. G. Arriaga, A. Gutierrez, J. Ledesma-Garcia
Summary: Ferrocene-based polymers have been widely studied as redox mediators in glucose biosensors. This work successfully modified poly-L-lysine (PLL) with ferrocene carboxylate and tested its performance as a redox mediator with glucose oxidase. The results showed remarkable activity and high selectivity. Scanning electrochemical microscopy was used to analyze the charged regions of the modified polymer on the electrode surface.
BIOELECTROCHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Betul Cicek Ozkan, Tugba Soganci Aras, Huseyin Turhan, Metin Ak
Summary: Interface design is crucial for biosensor development, as it directly influences the sensing performance. This study synthesized a new electroactive monomer and polymerized it onto chitosan and chitosan-reduced graphene oxide electrodes to create stable and reproducible sensor platforms. These sensors exhibited higher sensitivity, good selectivity, and long-term stability.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Analytical
Amir Zarei, Abdolhamid Hatefi-Mehrjaidi, Mohammad Ali Karimi, Alireza Mohadesi
Summary: In this study, a novel impedimetric glucose biosensor was fabricated using a biocomposite material and successfully applied for the analysis of real human blood serum samples. The biosensor showed a wide linear range, high sensitivity, and low detection limit. The fabrication process of the biosensor was simple and straightforward.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Nicole L. Walker, Jeffrey E. Dick
Summary: The development of a new electrochemical technique - open circuit potential, has been aimed at stable and reliable monitoring of biological metabolites. By immobilizing oxidase enzyme in chitosan hydrogel, the method achieves specificity in monitoring metabolites. This approach can effectively detect metabolites such as glucose and can be extended to detect other analytes.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Chuanfeng Huang, Yujun Cheng, Yiheng Zhang, Kai Zhao, Honglei Liu, Bo Zhang, Jiangyong Cao, Jiangtao Xu, Jingquan Liu
Summary: Using hollow metal cerium oxide (CeO2HNPs) surface continuously generating hydroxyl radicals, molecularly imprinted polymers (MIPs) were prepared under mild conditions with beta-D-glucose as the template molecule. A cascade catalytic system (CeO2HNPs@GOx-MIPs) with high specificity and selectivity for beta-D-glucose detection was obtained. The synthesized beta-D-glucose detection cascade catalytic system has broad application prospects in the precise sensing of monosaccharides and chemical food safety.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Yujun Cheng, Tao Chen, Donglei Fu, Maosheng Liu, Zhongfa Cheng, Yanfei Hua, Jingquan Liu
Summary: It has been found that glucose oxidase can catalyze diverse monosaccharides, which compromises the accuracy of glucose biosensors. In this study, multifunctional bi-nanospheres were constructed and used as a platform to immobilize large amounts of glucose oxidase probes. The biosensors obtained using this method showed selective glucose detection with high sensitivity.
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Materials Science, Multidisciplinary
Guan-Kai Huang, Shivam Gupta, Chi -Young Lee, Nyan-Hwa Tai
Summary: In this study, a noninvasive saliva glucose sensor was developed using polypyrrole (PPy) and acid-treated carbon nanotubes (acid-CNTs) deposited on a fluorine-doped tin oxide (FTO) conductive glass substrate. The sensor exhibited high sensitivity, selectivity, and stability, making it suitable for noninvasive diagnosis of diabetes.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Biophysics
Kavyashree Puttananjegowda, Arash Takshi, Sylvia Thomas
Summary: This study presents an electrochemical enzymatic glucose sensor with SiCNPs-ENFM nanostructure, which can detect glucose concentration with high sensitivity and good stability.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemistry & Molecular Biology
Gabriela Valdes-Ramirez, Laura Galicia
Summary: The biosensing membrane based on ferulic acid and glucose oxidase synthesized via cyclic voltammetry shows a linear response to glucose concentration, with high sensitivity and stability. The developed glucose biosensors exhibit a broader linear response compared to other polymer-based glucose biosensors.
Article
Chemistry, Analytical
Yue Wang, Jifan Zhao, Tian Yang, Yan Zhang, Dongping Tao, Yasushi Hasebe, Zhiqiang Zhang
Summary: Sulfide minerals were employed as a matrix for glucose oxidase immobilization in biosensors, showing good linear range, detection limits, and detection performance for glucose sensing. The results suggest that sulfide minerals are promising platforms for enzyme immobilization in biosensor applications.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yu Cai, Tingting Tu, Tianyu Li, Shanshan Zhang, Bin Zhang, Lu Fang, Xuesong Ye, Bo Liang
Summary: The study on the application of nanomaterials in glucose biosensors demonstrates excellent electrochemical performance, taking a step towards the development of the third-generation glucose biosensor.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Yu Cheng, Yuanhui Ji, Defang Ouyang
Summary: Targeted therapy from cells to mitochondria and combination therapy are hopeful strategies to overcome drug resistance. The self-assembled nanodrugs can inhibit cancer cell proliferation, induce apoptosis, promote reactive oxygen species production and mitochondrial membrane potential loss, block cells in S phase, and inhibit cancer cell movement and migration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Minying Wu, Qian Zhang, Yuanyuan Fang, Chao Deng, Fangzhou Zhou, Yi Zhang, Xingdong Wang, Yi Tang, Yajun Wang
Summary: Two-dimensional nanoreactors with cascade catalytic activity for glucose oxidation and hydrogen peroxide decomposition were prepared by immobilizing GOx on Ti3C2 MXene nanosheets. The GOx-conjugated Ti3C2-PLL nanosheets exhibited excellent enzymatic activities and were further deposited on glassy carbon electrode to construct a high-performance biosensor with a low glucose detection limit.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Analytical
Vygaile Dudkaite, Gintautas Bagdziunas
Summary: Enzymatic biosensors based on glucose oxidase have proven to be an effective strategy for detecting glucose and improving health. The development of third-generation biosensors using direct electron transfer enzymes offers a practical approach. In this study, a simple method was developed to functionalize glucose oxidase with redoxable ferrocene groups in chloroform, allowing for the detection of glucose while minimizing the formation of harmful substances.
Article
Materials Science, Biomaterials
Mehmet Senel, Fatma Ebru Koc
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2020)
Article
Biochemistry & Molecular Biology
Mehmet Senel, Muamer Dervisevic, Lars Esser, Esma Dervisevic, JenniSfer Dyson, Christopher D. Easton, Victor J. Cadarso, Nicolas H. Voelcker
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Analytical
Mehmet Senel, Muamer Dervisevic, Sammy Alhassen, Amal Alachkar, Nicolas H. Voelcker
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Physical
Emre Cevik, Huseyin Tombuloglu, Ismail Anil, Mehmet Senel, Hussein Sabit, Sayed AbdulAzeez, J. Francis Borgio, Mohammad Barghouthi
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2020)
Article
Chemistry, Analytical
Mehmet Senel, Esma Dervisevic, Sammy Alhassen, Muamer Dervisevic, Amal Alachkar, Victor J. Cadarso, Nicolas H. Voelcker
ANALYTICAL CHEMISTRY
(2020)
Article
Biotechnology & Applied Microbiology
Shaimaa Abdel-Ghany, Sara Raslan, Huseyin Tombuloglu, Aly Shamseddin, Emre Cevik, Osama A. Said, Engy F. Madyan, Mehmet Senel, Ayhan Bozkurt, Suriya Rehman, Hussein Sabit
Article
Chemistry, Multidisciplinary
Muamer Dervisevic, Maria Alba, Li Yan, Mehmet Senel, Thomas R. Gengenbach, Beatriz Prieto-Simon, Nicolas H. Voelcker
Summary: The microneedle array-based transdermal sensing system offers a pain-free alternative for continuous glucose monitoring of interstitial fluid. The system demonstrates good selectivity and sensitivity, with accurate correlation to blood glucose levels measured by a commercial glucometer.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Analytical
Mehmet Senel, Zehra Durmus, Amal Alachkar
Summary: The constructed clozapine sensor using reduced graphene oxide nanocomposites showed good linear range, detection limit, reproducibility, and reusability. Experimental results demonstrated a linear dynamic range of 0.05-10 μM clozapine with an actual detection limit of 50 nM under optimal experimental parameters.
Article
Biochemistry & Molecular Biology
Sammy Alhassen, Mehmet Senel, Amal Alachkar
Summary: In this study, we found that L-DOPA forms a stable complex with Scn in the presence of Fe3+ using surface plasmon resonance technique. The affinity constant (Kd) of the DOPA:Fe3+ binding with Scn was lower than L-DOPA plasma peak concentrations, suggesting a significant role for the L-DOPA-Scn complex in the decreased bioavailability of L-DOPA with the progression of PD.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Amal Alachkar, Sammy Alhassan, Mehmet Senel
Summary: In this study, a simple, robust, and stable microfluidic sensor was developed for real-time measurement of dopamine in cerebrospinal fluid from mice, with the advantages of low cost and small volume.
Article
Chemistry, Physical
T. Sagir, M. Huysal, M. Senel, S. Isik, N. Burgucu, O. Tabakoglu, M. Zaim
Summary: Novel folate-receptor-targeted polyamidoamine (PAMAM) dendrimer functional mesoporous silica-coated magnetic nanoparticles were prepared for drug delivery in photodynamic therapy. The nanoparticles showed efficient photodynamic therapy effect on MCF-7 cells, causing apoptosis.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ender Sarigul, Merve Zaim, Mehmet Senel, Tugba Sagir, Sevim Isik
Summary: A novel drug carrier was designed with an interior for drug encapsulation and a biocompatible surface, showing inhibitory effects on the proliferation of gastric adenocarcinoma cells.
Article
Chemistry, Analytical
Mehmet Senel
Summary: With the increasing number of patients suffering from Parkinson's disease, the measurement of drug levels in patient body fluids, particularly for clozapine, has become significantly important. There is a growing demand for a cost-effective platform that can analyze biofluids in real-time and in small volumes. This study aims to measure the level of clozapine using a portable potentiostat and a practical approach. The designed sensor showed good performance in terms of linearity, detection limit, reproducibility, and reusability. It was able to detect clozapine in real samples within a wide range of concentrations.
Article
Engineering, Biomedical
Eliz Selmin Paker, Mehmet Senel
Summary: In this study, PEI-grafted chitosan was successfully prepared for the fabrication of layer-by-layer films, and methylene blue was used as a model drug to investigate the drug loading and release behavior of the films. The results showed that the loading capacity and release rate of the model drug were influenced by ionic strength and pH, and PEI-grafted chitosan was demonstrated to be a suitable material for layer-by-layer films in drug delivery applications.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Biochemical Research Methods
Mehmet Senel, Amal Alachkar
Summary: A novel lab-in-a-pencil graphite microfluidic sensing electrode (mu FSE) was fabricated for real-time flow injection measurement of the antipsychotic drug clozapine (Clz), using a simple, low-cost, and reusable method. The mu FSE has tubular geometry with 800 mu m diameter, providing fast and effective Clz detection with good sensitivity and detection limit.
Article
Materials Science, Multidisciplinary
Katerina Skopalova, Itana Nusa Bubanja, Dragomir Stanisavljev, Nikola Cvjeticanin, Vera Kasparkova, Eliska Dad'ova, Erika Pavlikova, Marek Koutny, Marija Gizdavic-Nikolaidis, Petr Humpolicek
Summary: This study compares the biological properties of PANI prepared by different synthesis methods and oxidizing agents, which improves its potential applications in the biomedical field.
Article
Materials Science, Multidisciplinary
Hui-Ping Li, Cai-Yan Gao, Zhi-Ping Chen, Xin-Heng Fan, Lian-Ming Yang
Summary: In this study, a novel type of D-A non-fused-ring copolymers was designed and synthesized to overcome the trade-off relationship between electrical conductivity and Seebeck coefficient in organic semiconductors. The incorporation of fluorine atoms into the polymer backbone effectively increased the ordered degree of molecular stacking and improved both the electrical conductivity and Seebeck coefficient. The bimodal orientation of polymers played a crucial role in decoupling the correlation between electrical conductivity and Seebeck coefficient.
Article
Materials Science, Multidisciplinary
Mansour A. S. Salem, Amjad Mumtaz Khan, Hatem A. M. Saleh, Khalil M. A. Qasem, Mizna Ahmed, Aadil Shafi Bhat, Abdulaziz Abdullah Qasem Ali, Younes S. A. Ghanem, Ali Alrabie, Abdel-Basit Al-Odayni, Waseem Sharaf Saeed, Basheer Al-Anesi
Summary: This research focuses on the versatile substance, polyaniline/layered double hydroxide (PANI@Nd-Co/LDH), under solvothermal conditions. A thorough analysis of its structure and morphology was conducted using various analytical methods. The findings showed that PANI@Nd-Co/LDH exhibited highly sensitive and specific fluorescence detection of Pb(II) and Al(III), outperforming other heavy metal ions. The sensor demonstrated a turn-off fluorescence response for Pb(II) ions and a turn-on fluorescence response for Al(III) ions. The minimum detectable limits (MDL) were determined to be 9.6 nM for Pb(II) and 220 nM for Al(III). PANI@Nd-Co/LDH could be easily regenerated and reused for multiple cycles. The detection mechanisms involved the inner filter effect (IFE) for Pb(II) and the chelation-enhanced fluorescence (CHEF) effect for Al(III). These results highlight the excellent potential of PANI@Nd-Co/LDH in the detection and recognition of Pb(II) and Al(III) ions.
