Article
Chemistry, Multidisciplinary
Kurt F. Hoffmann, David Battke, Paul Golz, Susanne M. Rupf, Moritz Malischewski, Sebastian Riedel
Summary: In this study, two different routes for the synthesis of the perfluorinated trityl cation were presented, enabling the handling of the free, uncoordinated species in organic solvents for the first time. The weakly coordinating anion [Al(OTeF5)(4)](-) and its derivatives were used for the characterization of this species through NMR spectroscopy and single-crystal X-ray diffraction. The study demonstrated the high hydride ion affinity and oxidative potential of the cation, and successfully synthesized the ammoniumyl radical cation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Kensuke Kiyokawa, Naruyo Urashima, Satoshi Minakata
Summary: In this study, a method for the C3 cyanoalkylation of indoles using cyanohydrins in the presence of a B(C6F5)(3) catalyst was reported. Mechanistic investigations revealed the unique reactivity of the B(C6F5)(3) catalyst in promoting the decomposition of cyanohydrins. Additionally, a catalytic three-component reaction using indoles, aldehydes, and acetone cyanohydrin was developed for the synthesis of various types of indole-3-acetonitrile derivatives.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Electrochemistry
Parth Raval, Margot Dhennin, Herve Vezin, Tomasz Pawlak, Pascal Roussel, Thuc-Quyen Nguyen, G. N. Manjunatha Reddy
Summary: This study investigates the p-type doping of the hole-transporting material spiromadad in perovskite solar cells. The results provide insights into the doping process and distribution in the blended material, which is crucial for improving the stability and efficiency of hybrid perovskite photovoltaics.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Organic
Kensuke Kiyokawa, Ikumi Noguchi, Takaya Nagata, Satoshi Minakata
Summary: In this study, we present a bromocyanation reaction of styrene derivatives using cyanogen bromide in the presence of tris(pentafluorophenyl)borane as a Lewis acid catalyst. The reaction proceeds through a stereospecific syn-addition and provides a straightforward approach to beta-bromonitriles.
Article
Chemistry, Organic
Kensuke Kiyokawa, Ikumi Noguchi, Takaya Nagata, Satoshi Minakata
Summary: In this study, we demonstrate the bromocyanation of styrene derivatives with cyanogen bromide using tris(pentafluorophenyl)borane as a Lewis acid catalyst. This protocol enables a stereospecific syn-addition and provides an accessible route to beta-bromonitriles.
Review
Chemistry, Organic
Gautam Kumar, Sourav Roy, Indranil Chatterjee
Summary: Tris(pentafluorophenyl)borane (BCF) has gained significant attention in the synthetic chemistry community as a potential Lewis acid catalyst due to its thermal stability and commercial availability. Recent research has focused on exploring BCF's role in metal-free catalysis, with many new catalytic reactivities under investigation. The review mainly categorizes different types of organic transformations mediated through BCF catalysis for the formation of C-C and C-heteroatom bonds.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Jinbiao Jia, Jia Dong, Beibei Shi, Jihuai Wu, Yangqing Wu, Bingqiang Cao
Summary: Passivating defects to suppress recombination is an effective strategy to improve the performance of third-generation perovskite-based solar cells. The incorporation of tris(pentafluorophenyl)borane in SnO2-based planar perovskite solar cells effectively passivates Pb-0 defects, decreases grain boundaries quantity, enhances carrier transportation capability, and leads to a higher efficiency of 21.42%. Furthermore, the stability tests demonstrate that incorporating tris(pentafluorophenyl)borane in perovskite solar cells contributes to the device's stability.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Masatoshi Shibuya, Miki Matsuda, Yoshihiko Yamamoto
Summary: The study presents a novel single-step 1,2-dicarbofunctionalization method involving arylacetylene with an allylsilane and tris(pentafluorophenyl)borane [B(C6F5)(3)], leading to the formation of tetrafluoronaphthalenes. The unique reactivity of B(C6F5)(3) enables smooth reaction progress and can also result in ring opening in reactions with 2-substituted furan.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Ahmed E. Mansour, Ross Warren, Dominique Lungwitz, Michael Forster, Ullrich Scherf, Andreas Opitz, Moritz Malischewski, Norbert Koch
Summary: This study presents a simple method to enhance the oxidation strength of molecular dopants for organic semiconductors, while reducing diffusion in polymer hosts. Experimental results demonstrate higher efficiency of the new dopant complex compared to traditional molecular dopants.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Ayan Dasgupta, Rasool Babaahmadi, Sanjukta Pahar, Katarina Stefkova, Lukas Gierlichs, Brian F. Yates, Alireza Ariafard, Rebecca L. Melen
Summary: The study focuses on metal-free organic synthesis using triarylboranes as catalysts for the selective synthesis of N-substituted pyrazoles through the generation of carbenium species. DFT studies reveal that the in situ generation of a carbenium species serves as an autocatalyst to prompt the regiospecific formation of N-substituted pyrazoles in good to excellent yields (up to 81 %).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Hetian Gao, Andrew Battley, Erin M. Leitao
Summary: This article explores the broad utility of a commercially available and stable strong Lewis acid catalyst, tris(pentafluorophenyl)borane, highlighting its use in the synthesis of various siloxane products. By varying reaction conditions, precursor functionalities, reagent or catalyst loading, and considering the mechanistic factors, this catalyst offers different outcomes in a controlled and selective manner. It emphasizes the utility of tris(pentaflurophenyl)borane in the synthesis of linear, cyclic and macrocyclic siloxanes, aryl-/alkoxysiloxanes, and other bespoke products.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Xiao-Yang Wu, Wen-Xia Gao, Yun-Bing Zhou, Miao-Chang Liu, Hua-Yue Wu
Summary: A tris(pentafluorophenyl)borane-catalyzed oxidation reaction of alpha-diazoesters (alpha-diazo amides) with dimethyl sulfoxide has been developed to afford a series alpha-ketoesters and alpha-ketoamides under metal free conditions. The synthetic utility of this protocol is demonstrated through synthetic transformations and scaled-up synthesis.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Inorganic & Nuclear
Tommaso Giovenzana, Elena Lucenti, Lucia Carlucci, Giuseppe D'Alfonso, Daniela Maggioni, Angelo Sironi, Elena Cariati
Summary: In this study, Tris(pentafluorophenyl)silanol was prepared by an unconventional controlled hydrolysis method, and its reactivity with various bases and carbonyl complexes was investigated. The results showed that the Si-C6F5 bond can be easily cleaved, preventing the synthesis of certain derivatives.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Xiuling Wen, Peiquan Lu, Yong Shen, Haojie Peng, Zhuofeng Ke, Cunyuan Zhao
Summary: This study used density functional theory (DFT) calculations to elucidate the mechanism and origin of the diastereoselective cyclopropanation reaction of aryldiazodiacetate and styrene derivatives catalyzed by B(C6F5)(3). The most probable reaction mechanism was proposed, and the origin of diastereoselectivity was explained based on favorable interactions. The calculated results not only provide a detailed explanation of the mechanism but also have guiding significance for other catalytic cyclopropanation reactions.
Article
Chemistry, Organic
Steven M. Langdon, Michel Gravel
Summary: A route for the synthesis of 1,2,4-triazolium salts via oxidation of a thione precursor is demonstrated, with overall yields of 20-63%. Isolation and purification of the salts are simplified compared to traditional synthetic routes, and a variety of salts can be synthesized by late-stage selection of the counterion. These salts exhibit an appreciable counterion effect in both Stetter and cross-benzoin reactions.
Article
Chemistry, Applied
Teik Beng Goh, Rhun Yian Koh, Mun Fei Yam, Mat Easa Azhar, Mohd Nizam Mordi, Sharif Mahsufi Mansor
Article
Chemistry, Multidisciplinary
Teik Beng Goh, Mohd Nizam Mordi, Mas Rosemal Hakim Mas Haris, Sharif Mahsufi Mansor
MAGNETIC RESONANCE IN CHEMISTRY
(2015)
Article
Multidisciplinary Sciences
T. B. Goh, M. N. Mordi, S. M. Mansor
Article
Biology
Mohammed Nooraldeen Al-Qattan, Mohd Nizam Mordi, Sharif Mahsofi Mansor
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Armaghan Shafaei, Md Shamsuddin Sultan Khan, Abdalrahim F. A. Aisha, Amin Malik Shah Abdul Majid, Mohammad Razak Hamdan, Mohd Nizam Mordi, Zhari Ismail
Article
Chemistry, Organic
Ramu Meesala, Ahmad Saifuddin Mohamad Arshad, Mohd Nizam Mordi, Sharif Mahsufi Mansor
Article
Chemistry, Multidisciplinary
Mazlin Mohideen, Nur Azzalia Kamaruzaman, Ramu Meesala, Mohd Mustaqim Rosli, Mohd Nizam Mordi, Sharif Mahsufi Mansor
MOLECULAR CRYSTALS AND LIQUID CRYSTALS
(2017)
Article
Chemistry, Multidisciplinary
Mazlin Mohideen, Nur Azzalia Kamaruzaman, Mohd Mustaqim Rosli, Mohd Nizam Mordi, Sharif Mahsufi Mansor
MOLECULAR CRYSTALS AND LIQUID CRYSTALS
(2017)
Article
Pharmacology & Pharmacy
Hafiz Muhammad Irfan, Mohd Zaini Asmawi, Nurzalina Abdul Karim Khan, Amirin Sadikun, Mohd Nizam Mordi
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2017)
Article
Chemistry, Organic
Ramu Meesala, Ahmad Saifuddin Mohamad Arshad, Mallikarjuna Rao Pichika, Mohd Nizam Mordi, Sharif Mahsufi Mansor
Article
Biochemistry & Molecular Biology
Siti R. Yusof, Mahathir Mohd Uzid, Eng-Huat Teh, Nur Aziah Hanapi, Mazlin Mohideen, Ahmad Saifuddin Mohamad Arshad, Mohd Nizam Mordi, Irena Loryan, Margareta Hammarlund-Udenaes
Review
Pharmacology & Pharmacy
Yusuf Oloruntoyin Ayipo, Mohd Nizam Mordi, Muzaimi Mustapha, Thenmoly Damodaran
Summary: Neuropsychiatric disorders are complex diseases of the central nervous system, with treatment options remaining challenging. Beta-Carboline alkaloids, with their unique structural features, show promise for potential therapeutic agents against these disorders, although our understanding of their biological mechanisms in treating neuropsychiatric conditions is still limited.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yusuf Oloruntoyin Ayipo, Iqrar Ahmad, Yahaya Sani Najib, Sikirat Kehinde Sheu, Harun Patel, Mohd Nizam Mordi
Summary: In this study, four compounds with potential anti-SARS-CoV-2 activity were identified from the IBScreen database, among which STOCK1N-45901 was considered the most promising candidate and showed strong interactions with nsp3 and nsp12 enzymes. These compounds have the potential to be further developed as antiviral and anti-inflammatory agents.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biology
Yusuf Oloruntoyin Ayipo, Sani Najib Yahaya, Halimah Funmila Babamale, Iqrar Ahmad, Harun Patel, Mohd Nizam Mordi
Summary: The study screened 1497 beta C analogues and found that beta C ligands 129, 584, 1303, and 1323 showed higher binding affinities to the receptor, suggesting their potential as promising anti-SARS-CoV-2 candidates.
TURKISH JOURNAL OF BIOLOGY
(2021)
Article
Chemistry, Organic
Dilek Isik Tasgin, Irem Bayraktar
Summary: We present a synthetic method for pyrrolizine-3-one derivatives and investigate their photophysical properties. These compounds are prepared through a series of reactions involving substituted pyrroles in one-pot, two-step oxidation, and intramolecular cyclization processes. The photophysical properties of the synthesized compounds are studied using UV-Vis and fluorescence spectroscopy in various solvents. The introduction of pyrrolyl substituents has a significant impact on Stokes shifts and quantum yield values.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Satish Kumar Burra, Vaikunta Rao Lakinani, Raghunadh Akula, Chiranjeevi Yankkanti
Summary: A novel and green strategy for the construction of biologically relevant substituted indolyl-4H-chromenes scaffolds is reported, using L-proline as a catalyst and water as a promoter solvent. This catalytic system offers wider applicability, shorter reaction times, and high yields, making it an ideal condition for green chemistry.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Abouelhaoul El Alami, Amine El Maraghi, Fatima Youssoufi, Assiya Atif, Hamid Sdassi
Summary: Nitrobenzimidazoles have become increasingly important in the design of new compounds in medicinal, therapeutic and chemical fields. This review provides an overview of the synthesis strategies and biological activities of nitrobenzimidazole derivatives.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Nilesh Raghunath Khedkar, Alex Joseph, Milind Sindkhedkar
Summary: In this study, a new library of 3-(2-(pyrimidin-5-yl)thiazol-4-yl)-1,2,4-oxadiazole compounds was designed and synthesized as potential anticancer agents using in silico fragment-based drug design. The compounds were tested for their anticancer activity in vitro, and one compound exhibited excellent activity against multiple cancer cell lines.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Terungwa H. Iorkula, Bryce A. Tolman, Scott R. Burt, Matt A. Peterson
Summary: A new method for synthesizing C-6 substituted products has been discovered in this study, which utilizes lower doses of fluoride and CsF as a catalyst, with high reaction yields and cost-effectiveness under suitable conditions.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Ranjana Aggarwal, Swati Sharma
Summary: This review article mainly focuses on the synthesis of 3(5)-trifluoromethylpyrazoles via condensation reaction of trifluoromethyl-beta-diketones with hydrazines. It emphasizes the importance of fluorine-containing compounds and pyrazoles in the field of biology. The literature reported condensation reactions of trifluoromethyl-beta-diketones with hydrazines are covered.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
F. M. Alshareef, Sami A. Al-Harbi, Esam S. Allehyani, Omeima Abdullah, Magdy A. Ibrahim
Summary: This study aimed to construct a novel category of linear annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines. The chemical reactivity of the synthesized compounds was investigated, and they showed significant antimicrobial activity against various strains.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Preethi Dhanapal, S. L. Manju
Summary: Thiazole based Schiff base scaffolds have become an integral part of drug development in recent years, playing a versatile role as building blocks for lead drug molecules. This study presents a facile one pot synthetic method for producing novel 4-aryl thiazoles with high yield, shorter reaction time, and milder conditions, without the need for catalysts or purification techniques.
SYNTHETIC COMMUNICATIONS
(2024)
