☆ 4.3 Article

Efficient and Expeditious Synthesis of Di- and Trisubstituted Thiazoles in PEG Under Catalyst-Free Conditions

SYNTHETIC COMMUNICATIONS (2009)

期刊

SYNTHETIC COMMUNICATIONS

卷 39, 期 16, 页码 2895-2906

出版社

TAYLOR & FRANCIS INC

DOI: 10.1080/00397910802691874

关键词

-Haloketone; PEG-400; thiazoles; thioamides; thioureas

类别

Chemistry, Organic

资金

National Key Technology Research and Development Program [2007BAI34B00]
Natural Science Foundation of Zhengjiang Province [Y4080107]
Wenzhou University Postgraduate Innovation Foundation [YCX0716]

向作者/读者索取更多资源

Protocol

Reagent

摘要

An efficient and expeditious catalyst-free protocol was developed for the construction of di- and trisubstituted thiazoles from -haloketones and thioureas/thioamides in PEG. The reaction was carried out at ambient temperature, and the products were obtained in excellent isolated yields (91-98%). Additionally, PEG could be recovered easily and was reused without evident loss in activity.

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