Article
Chemistry, Organic
Xiaoyun Ma, Dan Liu, Zhengjian Chen
Summary: Trichloroacetonitrile is an efficient dehydrating agent for converting various aldoximes into nitriles, including aromatic and heterocyclic aldoximes, with moderate to good yields. The dehydration reactions can occur in non-acetonitrile media without the need for a metal catalyst, and trichloroacetonitrile itself undergoes conversion into trichloroacetamide during the reaction.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Microbiology
Robert Radisch, Miroslav Patek, Barbora Kristkova, Margit Winkler, Vladimir Kren, Ludmila Martinkova
Summary: This review focuses on the contribution of enzymes to plant-bacteria interactions, specifically discussing substrate specificities, taxonomic and ecological distribution, and importance in selected plant symbionts. The data shows that these enzymes are abundant in Actinobacteria and Proteobacteria and play important roles in breaking through plant defenses, utilizing aldoximes or nitriles as nutrients, and potentially contributing to the synthesis of the phytohormone indole-3-acetic acid.
Article
Environmental Sciences
Weilai Wang, Kaixuan Wang, Lei Xu, Yang Li, Junfeng Niu
Summary: Raney nickel coupled with nascent hydrogen (Nas-H-2) can efficiently catalyze the reduction of nitrate and nitrite (NOX-). The micro/nano-sized Nas-H-2 bubbles with fine dispersion of hydrogen molecules exhibit increased reactivity, and the alkaline environment positively maintains the activity of R-Ni. By introducing fine hydrogen resources, an efficient catalytic hydrogenation technique without noble metals can be developed.
Article
Chemistry, Applied
Bouchaib Mouhsine, Abdallah Karim, Clement Dumont, Isabelle Suisse, Mathieu Sauthier
Summary: A clean method has been developed for the a-allylation of phenyl and alpha alkyl phenyl acetonitrile with allylic alcohols, catalyzed by nickel complexes in situ at 80 degrees C in methanol. The protocol, which only yields water as a side-product, can synthesize many allylic nitriles with good yields.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Changzhou Chen, Dichao Wu, Peng Liu, Jing Li, Haihong Xia, Minghao Zhou, Jianchun Jiang
Summary: The study showed that by using 2D carbon nanostructure Ni3S2-CS catalysts with different compositions and temperatures, lignin model compounds could be effectively hydrogenolyzed to obtain corresponding ethylbenzene and phenol with high yields. The catalyst facilitated the cleavage of lignin ether bonds and showed good dispersion on carbon nanosheets, leading to optimal conversion rates.
Article
Chemistry, Analytical
Megan X. Y. Ravindran, N. Asikin-Mijan, H. C. Ong, Darfizi Derawi, M. R. Yusof, M. S. Mastuli, H. Lee, W. N. A. S. Wan Mahmood, M. S. Razali, G. Abdulkareem Al-Sultan, Y. H. Taufiq-Yap
Summary: This study investigated the catalytic reduction of oxygen-containing compounds in palm kernel oil using a microwave system approach. The use of Raney nickel and magnetite activated carbon-based catalysts significantly increased the yield and selectivity of bio-jet fuel. The study also revealed the important role of the catalyst's porous structure and active oxygen-containing groups in enhancing the deoxygenation reaction and improving the catalyst's reusability.
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
(2022)
Article
Chemistry, Organic
Masahiro Abe, Sayasa Nitta, Erina Miura, Tetsutaro Kimachi, Kiyofumi Inamoto
Summary: Herein, we present a simple method for the synthesis of nitriles via base-promoted intramolecular nucleophilic aromatic substitution. This process eliminates the need for toxic cyanide species and transition metals, while maintaining redox-neutral conditions. Our method demonstrates excellent scope and compatibility with various functional groups, resulting in good to excellent yields of (hetero)aromatic nitriles.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Engineering, Chemical
Xin Zhang, Wei-Kun Jiang, Bao-Ju Wang, Xiang-Yang Cui, Zhi-Yong Tang, Hai-Kui Zou, Guang-Wen Chu, Yong Luo
Summary: The intrinsic kinetics of catalytic hydrogenation of p-nitroanisole (PNA) to p-aminoanisole have been investigated in this study. Experimental and theoretical analyses were conducted under different conditions to determine the kinetic characteristics. Power law analysis revealed reaction orders for hydrogen and PNA, and Eley-Rideal and Langmuir-Hinshelwood-Hougen-Watson (LHHW) models were used to fit the data. The adsorption of dual-site dissociative H2 was identified as the rate-controlling step based on the LHHW model.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2022)
Article
Chemistry, Organic
Hongjie Gao, Jia-Yi Chen, Zhiqiang Peng, Lei Feng, Chen-Ho Tung, Wenguang Wang
Summary: Inspired by OxdA, we have developed an efficient iron catalyst that converts aldoximes to nitriles at room temperature. The catalysis involves redox activation of the N-O bond by the iron catalyst, offering a general method for the preparation of nitriles.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Run-Kai Fang, Zheng-Chun Yin, Jun-Shen Chen, Guan-Wu Wang
Summary: A convenient and efficient [3 + 2] cycloaddition reaction of alkenes and alkynes with the in situ generated nitrile oxides from aldoximes in the presence of NaCl, Oxone and Na2CO3 has been developed to afford a series of isoxazoles and isoxazolines at room temperature in yields up to 85% and 86%, respectively. The current methodology exhibits a wide substrate scope, (hetero)aromatic and aliphatic aldoximes, alkenes including acrylate esters, acrylonitrile, chalcone, styrene, N-methylmaleimide and [60]fullerene, phenylacetylene, and alkynes containing CH2OH, SiMe3, COCH3 or CO2CH3 group can be employed. The present protocol features good functional group tolerance, short reaction time, mild reaction conditions and high atom economy, providing an efficient and environmentally friendly access to isoxazoles and isoxazolines.
GREEN CHEMISTRY LETTERS AND REVIEWS
(2022)
Article
Chemistry, Physical
Patrick M. Barboun, Luke L. Daemen, Craig Waitt, Zili Wu, William F. Schneider, Jason C. Hicks
Summary: The study reports INS observations of alumina-supported Ni particles after treatment with N-2 and H-2 plasmas, revealing the presence of NHx species and hydrides, generated through plasma-facilitated surface reactions. Experimental assignments of surface intermediates through INS spectra support the direct implication of plasma stimulation of dinitrogen in generation of surface-bound reactions. The results suggest that these reactions can be driven thermally or with H(2) plasma.
ACS ENERGY LETTERS
(2021)
Article
Chemistry, Organic
P. Purnachandra Rao, Shaik Nowshuddin, Anjali Jha, B. Leela Maheswara Rao, Murali K. Divi, M. N. A. Rao
Summary: Bmpc, in the presence of a base, efficiently converts primary amides into nitriles, with enantiomeric integrity maintained and high yields achieved.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Physical
Jianghao Zhou, Jing Guo, Alexander Moiseevich Mebel, Govinda Ghimire, Feng Liang, Shuai Chang, Jin He
Summary: Investigated the dehydration reaction of primary amides in visible-light driven self-assembled gold nanoparticle-aromatic primary amide-gold nanoelectrode junctions. Used time-resolved surface enhanced Raman spectroscopy (SERS) to study the reaction dynamics and intermediates, revealing the role of gold surface adatoms and picocavities in stabilizing and amplifying the intermediates.
Article
Chemistry, Applied
Wang Yin, Hanwen Gu, Monique Bernardes Figueiredo, Shuqian Xia, Robertus Hendrikus Venderbosch, Hero Jan Heeres
Summary: The study focused on catalytic hydrotreatment of fast pyrolysis liquids from lignocellulosic biomass using different types of Raney nickel catalysts, with Mo-promoted Ra-Ni catalyst showing the highest hydro-(deoxy)genation activity and lowest charring tendency of the product oil. The analyses of product oils revealed the presence of a significant amount of phenolics, indicating the potential of commercially available Raney nickel catalysts, particularly the Mo-promoted ones, for mild hydrotreatment of pyrolysis liquids.
FUEL PROCESSING TECHNOLOGY
(2021)
Article
Chemistry, Applied
Young Hwa Yun, Kwangsoo Kim, Changsoo Lee, Byeong-Seon An, Ji Hee Kwon, Sechan Lee, Minjoong Kim, Jongsu Seo, Jong Hyeok Park, Byung-Hyun Kim, Hyun-Seok Cho
Summary: In this study, Ni-based porous electrocatalysts with excellent hydrogen evolution activity were prepared by controlling the chemical state of Ni using plasma vapor deposition (PVD) and subsequent heat treatment, selective Al leaching, and electrochemical reduction. The presence of NiAl intermetallic compound at the interfaces facilitated the partial reduction of Ni(OH)2 and enhanced the efficiency of hydrogen evolution. This research is of great importance for improving the hydrogen production reaction in alkaline water electrolysis.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Chemistry, Organic
Dilek Isik Tasgin, Irem Bayraktar
Summary: We present a synthetic method for pyrrolizine-3-one derivatives and investigate their photophysical properties. These compounds are prepared through a series of reactions involving substituted pyrroles in one-pot, two-step oxidation, and intramolecular cyclization processes. The photophysical properties of the synthesized compounds are studied using UV-Vis and fluorescence spectroscopy in various solvents. The introduction of pyrrolyl substituents has a significant impact on Stokes shifts and quantum yield values.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Satish Kumar Burra, Vaikunta Rao Lakinani, Raghunadh Akula, Chiranjeevi Yankkanti
Summary: A novel and green strategy for the construction of biologically relevant substituted indolyl-4H-chromenes scaffolds is reported, using L-proline as a catalyst and water as a promoter solvent. This catalytic system offers wider applicability, shorter reaction times, and high yields, making it an ideal condition for green chemistry.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Abouelhaoul El Alami, Amine El Maraghi, Fatima Youssoufi, Assiya Atif, Hamid Sdassi
Summary: Nitrobenzimidazoles have become increasingly important in the design of new compounds in medicinal, therapeutic and chemical fields. This review provides an overview of the synthesis strategies and biological activities of nitrobenzimidazole derivatives.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Nilesh Raghunath Khedkar, Alex Joseph, Milind Sindkhedkar
Summary: In this study, a new library of 3-(2-(pyrimidin-5-yl)thiazol-4-yl)-1,2,4-oxadiazole compounds was designed and synthesized as potential anticancer agents using in silico fragment-based drug design. The compounds were tested for their anticancer activity in vitro, and one compound exhibited excellent activity against multiple cancer cell lines.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Terungwa H. Iorkula, Bryce A. Tolman, Scott R. Burt, Matt A. Peterson
Summary: A new method for synthesizing C-6 substituted products has been discovered in this study, which utilizes lower doses of fluoride and CsF as a catalyst, with high reaction yields and cost-effectiveness under suitable conditions.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Ranjana Aggarwal, Swati Sharma
Summary: This review article mainly focuses on the synthesis of 3(5)-trifluoromethylpyrazoles via condensation reaction of trifluoromethyl-beta-diketones with hydrazines. It emphasizes the importance of fluorine-containing compounds and pyrazoles in the field of biology. The literature reported condensation reactions of trifluoromethyl-beta-diketones with hydrazines are covered.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
F. M. Alshareef, Sami A. Al-Harbi, Esam S. Allehyani, Omeima Abdullah, Magdy A. Ibrahim
Summary: This study aimed to construct a novel category of linear annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines. The chemical reactivity of the synthesized compounds was investigated, and they showed significant antimicrobial activity against various strains.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Preethi Dhanapal, S. L. Manju
Summary: Thiazole based Schiff base scaffolds have become an integral part of drug development in recent years, playing a versatile role as building blocks for lead drug molecules. This study presents a facile one pot synthetic method for producing novel 4-aryl thiazoles with high yield, shorter reaction time, and milder conditions, without the need for catalysts or purification techniques.
SYNTHETIC COMMUNICATIONS
(2024)
