期刊
SYNTHETIC COMMUNICATIONS
卷 39, 期 2, 页码 197-204出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910701860323
关键词
Aryl iodide; benzo[b]furan; 2-methyl-3-butyn-2-ol; o-iodophenol; Sonogashira reaction
资金
- State Key Laboratory of Applied Organic Chemistry
A simple, convenient, and efficient one-pot method for the preparation of benzofuran is reported. Sonogashira coupling reaction of aryl iodides with 2-methyl-3-butyn-2-ol was used as an acetylene source in the presence of Pd(PPh3)2Cl2 and CuI. Deprotection of the acetylene moiety in the same pot using a strong base and the second Sonogashira coupling/cyclization of and substituted o-iodophenols led to the formation of the appropriate benzo[b]furans. These protocols also can be used in the synthesis of natural products and indoles.
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