期刊
SYNTHESIS-STUTTGART
卷 46, 期 10, 页码 1380-1388出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1341026
关键词
N-alkylation; alcohol; theophylline; TsTh; DBU
资金
- Shiraz University of Technology Research Council
A convenient and highly efficient one-pot N-alkylation of theophylline from alcohols via N-7-tosyltheophylline (TsTh) is described. In this protocol, the treatment of primary and/or secondary alcohols with a mixture of TsTh and 1,8-diazabicyclo[5.4.0]undec-7-ene in refluxing acetonitrile affords the corresponding N-7-alkyltheophylline in good to excellent yields; the reaction was optimized for solvent and base. This methodology is highly efficient for various structurally diverse primary and secondary alcohols. A plausible mechanism for the one-pot N-alkylation of theophylline with alcohols via TsTh has been suggested.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据