期刊
SYNTHESIS-STUTTGART
卷 45, 期 7, 页码 874-887出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1318325
关键词
radical reaction; nitriles; photochemistry; cyanation; C-H functionalizations
资金
- Funding Program for Next Generation World-Leading Researchers (JSPS)
A general and practical synthetic protocol for the direct transformation of unreactive C(sp(3))-H bonds to C(sp(3))-CN bonds has been developed. The homolytic cleavage of the C-H bond is initiated by photo-excited benzophenone, and the resulting carbon radical subsequently reacts with tosyl cyanide to afford the corresponding nitrile in a highly efficient manner. The present methodology is widely applicable to various starting materials including ethers, alcohols, amine derivatives, alkanes, and alkylbenzenes. This newly developed C-H cyanation protocol provides a powerful tool for selective one-carbon elongation for the construction of architecturally complex molecules.
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