期刊
SYNTHESIS-STUTTGART
卷 45, 期 12, 页码 1659-1666出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1338844
关键词
domino reactions; ketones; amides; cyclizations; cycloalkanes; stereoselectivity; catalysis; thioureas
资金
- Agence Nationale pour la Recherche [ANR-11-BS07-0014]
- Centre National de la Recherche Scientifique (CNRS)
- Aix-Marseille Universite
- Agence Nationale de la Recherche (ANR) [ANR-11-BS07-0014] Funding Source: Agence Nationale de la Recherche (ANR)
Several reactive sites of 1,2- and 1,3-ketoamides were successively exploited in two complementary domino transformations for the synthesis of polysubstituted monocyclic or bridged bicyclic cyclohexanes, with the creation of up to six stereogenic centers. In both cases, a chiral bifunctional thiourea organocatalyst allowed efficient control of chirality in the final carbocycle.
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