期刊
SYNTHESIS-STUTTGART
卷 44, 期 24, 页码 3789-3796出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1317524
关键词
allenes; axial chirality; desymmetrization; biocatalysis; 5-endo-trig cyclization
资金
- Fonds der Chemischen Industrie
Lipase from Pseudomonas fluorescens efficiently catalyzes the transesterification of prochiral tetrasubstituted allenic diols yielding highly enantioenriched axially chiral allenyl monoesters. In combination with subsequent 5-endo-trig cyclizations geminally disubstituted dihydrofurans are accessible in high optical purity.
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