Stereoselective Synthesis of the C1-C11 Tetrahydropyran Core Unit of (+)-Zincophorin

Synthesis of the C1-C11 tetrahydropyran core unit of (+)-zincophorin using a desymmetrization strategy is reported. Horner-Wadsworth-Emmons (HWE) and Mitsunobu cyclization reactions are the key transformations.