期刊
SYNTHESIS-STUTTGART
卷 -, 期 22, 页码 3913-3917出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1258249
关键词
spirooxindole; 1,4-dihydropyridine; malononitrile; 1,n-diamine; 1,1-bis(methylthio)-2-nitroethylene; multicomponent reaction
An efficient, one-pot synthetic protocol toward spirooxindole derivatives containing 1,4-dihydropyridine-fused 1,3-diaza-heterocycle fragments, a class of biologically active compounds starting from 1,1-bis(methylthio)-2-nitroethylene, 1, n-diamine, isatin, or its derivatives, and malononitrile is described. The reaction proceeds in ethanol in the presence of 10 mol% of piperidine as a basic catalyst under reflux conditions to produce the title compounds in 74-85% yields.
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