期刊
SYNTHESIS-STUTTGART
卷 -, 期 23, 页码 4010-4014出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1217052
关键词
alkylation; carbazoles; indole; tert-butyl alcohol; hexane-2,5-diol; montmorillonite K-10; microwave heating; annulation
Alcohols are considered environmentally benign alkylating agents since the only by-product generated in their reactions is water. Herein, we report a microwave-assisted Friedel-Crafts alkylation and electrophilic annulation of indoles using alcohols as alkylating agents. Alkylation of indoles using tert-butyl alcohol gives 3-substituted tert-butylindoles. A domino electrophilic annulation/aromatization of indoles using hexane-2,5-diol results in the formation of substituted carbazoles. The reaction is catalyzed by a strong, solid-acid catalyst montmorillonite K-10. The products were obtained in good yields and high selectivities.
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