☆ 4.5 Article

Synthesis of (Z)-2-[(Z)-3-alkylideneisobenzofuran-1(3H)-ylidene]acetic acid derivatives by sequential coupling-cyclization between 3-(2-iodophenyl)-3-oxopropanoic acid derivatives and terminal alkynes

SYNTHESIS-STUTTGART (2008)

期刊

SYNTHESIS-STUTTGART

卷 -, 期 7, 页码 1094-1098

出版社

GEORG THIEME VERLAG KG

DOI: 10.1055/s-2008-1032120

关键词

alkynes; coupling; furans; palladium; ring closure

类别

Chemistry, Organic

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Reagent

摘要

3-(2-Iodophenyl)-3-oxopropanoic acid derivatives reacted efficiently with various terminal alkynes in the presence of catalytic amounts of dichlorobis(triphenylphosphine)palladium and copper(l) iodide and two molar amounts of triethylamine in N,N-dimethylformamide at room temperature to afford the corresponding (Z)-2- [(Z)-3-alkylideneisobenzofuran-1 (3 H)-ylidene]acetic acid derivatives in reasonable yields.

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