☆ 4.4 Article

Synthesis of 2,4,6-Triarylpyridines Using ZrOCl2 under Solvent-Free Conditions

SYNLETT (2014)

期刊

SYNLETT

卷 25, 期 2, 页码 193-196

出版社

GEORG THIEME VERLAG KG

DOI: 10.1055/s-0033-1340088

关键词

pyridine; multicomponent reactions; zirconium; Krohnke pyridine; solvent-free

类别

Chemistry, Organic

资金

Research Affairs Office of Bu-Ali Sina University [32-1716]
Center of Excellence in Development of Chemical Methods (CEDCM), Hamedan, I. R. Iran

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摘要

An efficient procedure for the synthesis of 2,4,6-triarylpyridines (Krohnke pyridines) by the one-pot multicomponent condensation of aldehydes (1 equiv) with acetophenones (2 equiv) and ammonium acetate (1.2 equiv) in the presence of catalytic amounts of oxozirconium(IV) chloride (ZrOCl2) under solvent-free conditions is described. In this work, four products have been reported for the first time. Easy work-up, simple methodology, clean reaction and reusability of the catalyst are some advantages of this work.

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