期刊
SYNLETT
卷 24, 期 13, 页码 1599-1605出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1339284
关键词
cyanuric chloride; nucleophilic substitution; solid-phase; solution-phase; library synthesis
资金
- Damon Runyon Cancer Research Foundation [DRR-18-12]
- Smith Family Foundation
- Boston College
1,3,5-Triazine derivatives have widespread applications in the pharmaceutical, material, and agrochemical industries. In the biological arena, small-molecule libraries of 2,4,6-trisubstituted 1,3,5-triazines have yielded selective and potent chemical probes for diverse protein families. The structural symmetry and ease of functionalization of the 1,3,5-triazine core renders it a powerful scaffold for the rapid generation of diverse molecular libraries. Numerous synthetic routes, both solid-phase and solution-phase, have been developed to arrive at alkyl/aryl amino-and oxy-substituted triazine libraries. Here, we feature a subset of the recent synthetic advances towards generating 2,4,6-trisubstituted 1,3,5-triazines and highlight biologically active compounds that have resulted from these endeavors.
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