期刊
SYNLETT
卷 -, 期 8, 页码 1181-1186出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1290666
关键词
palladium; cross-coupling; amination; aryl chlorides; phosphine
资金
- Research Grants Council of Hong Kong (CERG) [PolyU5005/07P]
- PolyU [A-PG13]
- SKL of Chirosciences
This study describes the efficacy of benzimidazolyl phosphine ligands, which are easily synthesized from inexpensive and commercially available o-phenylenediamine, 2-bormobenzoic acid, and chlorophosphines, in the Buchwald-Hartwig amination of aryl chlorides. Primary and secondary aromatic/aliphatic amines are effective substrates in this catalytic system. Functional groups such as keto and esters are also compatible. The catalyst loading can be reduced to 0.1 mol% Pd.
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