期刊
SYNLETT
卷 -, 期 20, 页码 2875-2879出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1317478
关键词
hydroamination; allenes; N,O-acetal; piperidines; diversity
资金
- National Research Foundation
- Korean government [NRF-2009-0073749]
- KOSEF through EPB center [2012-0000534]
- National Research Foundation of Korea [2009-0073749, 2008-0061957] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Developing chemical reactions that rapidly introduce molecular diversity in a controlled manner represents a prime goal in synthetic organic chemistry. In this regard, our recent studies on the asymmetric synthesis and utilization of stereodefined N,O-acetal opens up a conceptually new methodology. The synthesis of labile N,O-acetals was accomplished by highly efficient and chemoselective Pd-catalyzed asymmetric hydroamination of alkoxyallenes. Furthermore, the utility of the stereodefined N,O-acetals as a stereodiversity-generating element was established by the gold-catalyzed cycloisomerization. In addition to these results, new aspects of the N,O-acetals as diversity-generating elements are also discussed.
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