Article
Chemistry, Organic
Charles S. Jolly, Emma Kochanowski, Cayden J. Dodd, Savannah J. Post, Harrison M. Hill, Mark Turlington
Summary: The stereoselective synthesis of terminal bromosubstituted propargylamines via in situ generation of lithium bromoacetylide from 1,2-dibromoethene and addition to Ellman chiral N-tert-butanesulfinyl aldimines is reported. The method allows for the direct use of the prepared propargylamines in Cadiot-Chodkiewicz coupling to produce functionalized diynes, increasing the structural diversity of these compounds.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Hyun-Jong Lee, Ji-Hyun Cha, Duk-Young Jung
Summary: Heterometallic Cu-In and Cu-Ga complex salts, [Cu(III)(dedtc)2][In(III)Cl4] and [Cu(III)(dedtc)2][Ga(III)Cl4], were synthesized through oxidation reactions of Cu(II)(dedtc)2, In(III)Cl3, and Ga(III)I3. The crystal structures of Cu-In and Cu-Ga complexes were confirmed and exhibited distorted octahedral structures with Cu-S chains surrounded by dimeric [M(III)Cl4]- and benzene.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Applied
Akash Kumar, Shelly Kujur, Jyoti Prabha Kujur, Richa Sharma, Devendra Deo Pathak
Summary: In this study, a copper-triazine-dendrimer-functionalized graphene oxide (CTD-GO) catalyst was synthesized for the first time and its structure was confirmed using various techniques. The catalyst showed excellent catalytic activity and recyclability in the A(3)-coupling reaction in water.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Thermodynamics
Lijiang Guo, Quanbao Zhou, Dewen Zeng
Summary: Water activities of CuCl2-MCl2-H2O (M=Mg, Ca) ternary systems and their sub-binary systems were measured at 298.15K, with results showing that the Reaction model successfully predicted the water activity and solubility in these systems. The Pitzer model and PSC model were found to be inconsistent in representing the thermodynamic properties of these systems. The study also demonstrated how the Reaction model accounted for the distribution of Cu-bearing species in relation to MgCl2 (CaCl2) molalities and the influence of electrolyte solution structure variation on macroproperties.
FLUID PHASE EQUILIBRIA
(2021)
Article
Chemistry, Organic
Hyun Jo Kim, Ji Eun Lee, Ganesh Koyyada, Mohan Lakavathu, Jae Hong Kim
Summary: In this study, a straightforward approach using 1,10-phenanthroline copper(I) complexes as a catalyst for the coupling reaction between alkynes and amines was reported. This method can be used to generate polyfunctional amino analogues. The addition of zinc halide or the use of Sc(OTf)(3) allowed the transformation of the products into different compounds.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Jeehye Kim, Youn Jeong Jang, Woonhyuk Baek, A. Reum Lee, Jae-Yup Kim, Taeghwan Hyeon, Jae Sung Lee
Summary: This study demonstrates a highly efficient type II heterojunction photoanode composed of non-toxic CuIn1.5Se3 (CISe) quantum dots and a mesoporous TiO2 film, with ZnS/SiO2 double overlayers deposited on the photoanodes to passivate surface defect sites on the CISe QDs. The combination of wide light absorption range of CISe QDs and reduced interfacial charge recombination by the overlayers results in a remarkable photocurrent density of 8.5 mA cm(-2) under 1 sun illumination, setting a record for PEC sulfite oxidation based on non-toxic QD photoanodes.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Zhongwen Sun, Lijun Chen, Kaixiong Qiu, Bo Liu, Hongtao Li, Fang Yu
Summary: A catalytic enantioselective addition of C-alkynyl imines with hydroperoxides catalyzed by chiral BINOL calcium phosphate was reported, yielding a broad range of enantioenriched alpha-peroxy propargylamines in good yields (80-99%) with high enantioselectivities (up to 94% ee). The protocol is characterized by mild conditions, easy accessibility, and good practicability.
CHEMICAL COMMUNICATIONS
(2022)
Article
Materials Science, Ceramics
F. Z. Nouasria, D. Selloum, A. Henni, D. Zerrouki, S. Tingry
Summary: This study successfully synthesized and characterized Cu-doped ZnO nanorods by an electrochemical method in the presence of two different Cu precursors, aiming to enhance photocurrent generation. The doped ZnO nanorods showed significant changes in morphology distortion, increased transmittance, and reduced energy gap, while photoelectrochemical tests demonstrated improved photocurrent density under Cu doping, indicating enhanced efficiency in separating photogenerated electron-hole pairs. These results hold promise for optoelectronic and photocatalysis applications.
CERAMICS INTERNATIONAL
(2021)
Article
Nanoscience & Nanotechnology
Yijin Wang, Junli Nie, Zhang He, Yuanhong Zhi, Xiaohua Ma, Peng Zhong
Summary: This study reports a composite photothermal membrane based on MXene nanoflakes and copper indium selenide nanoparticles for highly efficient solar-driven interface evaporation in water treatment. The results show that the composite membrane has advantages in improving light-to-heat conversion efficiency and impurity removal ability, and it also exhibits excellent durability and adaptability to light intensity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Metallurgy & Metallurgical Engineering
Flavio Luiz Martins, Versiane Albis Leao
Summary: The increasing demand for copper worldwide has led to the need for processing larger amounts of copper ores. However, the refractory nature of chalcopyrite, the most abundant copper mineral, hinders efficient hydrometallurgical processes. Researchers have suggested using high temperatures and reagents such as sodium chloride to overcome this refractoriness. Bioleaching has been proposed as an economic and environmentally friendly alternative to traditional chemical processes. However, the tolerance of acidophilic microorganisms used in bioleaching to high chloride concentrations remains a challenge.
Article
Chemistry, Physical
Chenqi Shen, Pengtang Wang, Leigang Li, Xiaoqing Huang, Qi Shao
Summary: Syngas is a crucial feedstock for producing synthetic fuels and chemicals, and utilizing copper-indium catalysts with modulated structure and phase can efficiently produce syngas with tunable CO/H2 ratios. This strategy highlights a simple yet efficient approach for designing potential electrocatalysts for producing syngas with widely adjustable CO/H2 ratios.
Article
Chemistry, Physical
Mingzhen Quan, Yan Xiong, Yiliang Xu, Mingyang Li, Mingyue Chen, Jindong Cao, Jing Zhao, Quanlin Liu
Summary: In this study, two zero-dimensional indium-based halides were reported, and 1% antimony-doped (C3H12N2)3In2Cl12 center dot 2 H2O exhibited more intense, broader emission with a larger Stokes shift compared to 1% antimony-doped (C3H12N2)2InCl7.
JOURNAL OF ALLOYS AND COMPOUNDS
(2024)
Article
Chemistry, Organic
Li-Qin Yan, Zhenzhen Yin, Xinwei He, Qianqian Li, Ruxue Li, Jiahui Duan, Keke Xu, Qiang Tang, Yongjia Shang
Summary: A novel and versatile approach has been developed for the construction of 12-phenacyl-11H-benzo[b]xanthene-6,11(12H)-dione derivatives through a copper-catalyzed cascade reaction. This method provides a highly efficient synthesis of these derivatives in a single step from readily available starting materials, forming new bonds and a heterocycle.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Meng-Hao Yi, Hai-Shan Jin, Ru-Bing Wang, Li-Ming Zhao
Summary: An efficient copper-catalyzed cascade annulation of o-hydroxyphenyl propargylamines and pyrazolin-5-ones is described, leading to the rapid assembly of a series of valuable pyrano[2,3-c]pyrazoles with good yields across a wide range of substrates in a simple fashion. The mechanistic elucidation is well supported by control experiment and literature precedents.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Deewakar Poudel, Benjamin Belfore, Tasnuva Ashrafee, Shankar Karki, Grace Rajan, Angus Rockett, Sylvain Marsillac
Summary: Post-deposition treatments with indium bromide vapor at 400 and 500 degrees Celsius lead to larger grains and higher conductivity in Cu(In,Ga)Se-2 thin films compared to simple annealing under selenium. These properties are attributed to a modification of elemental profiles, particularly for gallium and sodium.
Article
Chemistry, Organic
Farrukh Sajjad, Alavala Gopi Krishna Reddy, Dong Xing, Suzhen Dong, Wenhao Hu
Summary: An unprecedented synthetic route towards a variety of 3-anilino-1H-indoles has been achieved through a domino ruthenium-catalyzed annulation and subsequent iron-promoted fragmentation and rearrangement. The strategy is applicable to deliver diversely substituted indole esters, with compound 4i exhibiting the best inhibitory activity with an IC50 value of 0.05 mu M, paving the way for the discovery of promising lead compounds in the future.
Article
Chemistry, Multidisciplinary
Guizhi Dong, Ming Bao, Xiongda Xie, Shikun Jia, Wenhao Hu, Xinfang Xu
Summary: The study presents an unprecedented catalytic asymmetric allylation of isatins and isatin-derived ketimines via a gold and chiral organocatalyst cooperative catalysis strategy, leading to the expeditious synthesis of chiral 2,5-disubstituted alkylideneoxazolines with vicinal stereogenic centers. The mechanism involves an alkylgold intermediate, and the X-ray crystal structure of the allylgold species reveals its unique stability and reactivity. Additionally, an asymmetric formal hetero-ene reaction of the gold intermediate is enabled with the assistance of a quinine-derived squaramide catalyst, extending the synthetic applications of gold complexes and the versatility of gold catalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Medicinal
G. Lakshma Reddy, Rupam Sarma, Shuhao Liu, Weifeng Huang, Jinping Lei, Jiasheng Fu, Wenhao Hu
Summary: This study describes the design and synthesis of novel benzo[4,5]imidazo[1,2-a]pyrazin-1-amine derivatives, which showed promising A(2A) adenosine receptor antagonist activity, with compound 27 demonstrating good activity and potential application in T-cell activation. Molecular docking studies were conducted to explain the observed binding affinity of compound 27.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ming Bao, Jinzhou Chen, Chao Pei, Sujie Zhang, Jinping Lei, Wenhao Hu, Xinfang Xu
Summary: An unprecedented gold-catalyzed ketene C=O/C=C bifunctionalization method has been developed, initiated by gold-catalyzed Wolff rearrangement of diazoketone to form the ketene intermediate, followed by nucleophilic addition and terminated with two divergent cyclization processes. Depending on the nucleophiles used, different cyclization pathways are observed, leading to the formation of different products, providing a novel reaction pattern for the ketene dual functionalization.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Applied
Ming Bao, Xiongda Xie, Wenhao Hu, Xinfang Xu
Summary: A gold-catalyzed carbocyclization/C=N bond formation cascade reaction has been developed for the synthesis of polyfunctionalized 4-iminonaphthalenones and indenes in good to high yields under mild reaction conditions. The resulting products could be converted into multi-substituted 2-naphthol derivatives in high yields.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Physical
Kemiao Hong, Shanliang Dong, Xinxin Xu, Zhijing Zhang, Taoda Shi, Haoxuan Yuan, Xinfang Xu, Wenhao Hu
Summary: An enantioselective intermolecular Mannich-type interception of phenolic oxonium ylides with imines has been developed using cooperative catalysis with achiral dirhodium complex and chiral phosphoric acid. The synthesis of enantioenriched 2,2-disubstituted dihydrobenzofurans with good to high yield and high to excellent enantioselectivity under mild conditions was achieved. Preliminary antitumor activity study showed high anticancer potency of the reduction product 7 against human lung adenocarcinoma cells (A549 cells, IC50 = 9.13 mu M).
Article
Chemistry, Multidisciplinary
Zhenghui Kang, Wenju Chang, Xue Tian, Xiang Fu, Wenxuan Zhao, Xinfang Xu, Yong Liang, Wenhao Hu
Summary: The study presents a novel asymmetric allylation reaction through ternary cooperative catalysis, enabling the expedient access to chiral alpha,alpha-disubstituted ketones with high enantioselectivity. Experimental and computational studies have elucidated the mechanism and origin of enantioselectivity in this three-component reaction.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Organic
Xiangrong Liu, Xue Tian, Jiawu Huang, Yu Qian, Xinfang Xu, Zhenghui Kang, Wenhao Hu
Summary: An enantioselective three-component reaction of alpha-propargylic-3-indolymethanol with diazoindolinone and alcohol has been achieved under the cocatalysis of Rh(II) and chiral phosphoric acid (CPA). The reaction proceeds through regio- and enantiospecific addition of an in situ formed oxonium ylide to the alpha-propargylic indole iminium ion, providing an efficient access to chiral propargylic indole derivatives with high yields and enantioselectivities.
Article
Chemistry, Physical
Yong-Liang Su, Geng-Xin Liu, Luca De Angelis, Ru He, Ammar Al-Sayyed, Kirk S. Schanze, Wen-Hao Hu, Huang Qiu, Michael P. Doyle
Summary: This study demonstrates the efficient generation of functionalized derivatives through photocatalyzed multicomponent reactions using nitrogen aromatic heterocycles, alkenes, and diazo compounds. The reaction shows high functional group tolerance and exacting regioselectivities. Mechanistic studies, including photophysical measurements, provide insights into this radical cascade reaction.
Article
Chemistry, Organic
Xiang Fu, Jie Tang, Ruyu Hua, Xiaoqian Li, Zhenghui Kang, Huang Qiu, Wenhao Hu
Summary: This study reports two DNA-compatible reactions with alkenes and diazo compounds, providing hydroalkylation and cyclopropanation products in moderate to excellent yields. These transformations not only offer new access to C(sp3)-C(sp3) bond formation in DELs with excellent functional group tolerance, but also represent practical ligation methods to introduce functionalized molecules into DNA.
Article
Chemistry, Organic
Su Zhou, Qianqian Liu, Ming Bao, Jie Huang, Junjian Wang, Wenhao Hu, Xinfang Xu
Summary: A new synthesis method for 2-indolyl indolone N-oxides via gold(i)-catalyzed cascade reaction of o-nitroalkynes with indoles has been developed, leading to highly efficient conversion into 2-indolylbenzoxazinone with strong blue fluorescence. The synthesized compounds were also evaluated for their antitumor activity in small cell lung cancer, with compounds 3d and 4s showing high anticancer potency against SCLC cells.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Kai Zhou, Ming Bao, Hongkai Sha, Guizhi Dong, Kemiao Hong, Xinfang Xu, Wenhao Hu
Summary: A Rh-catalyzed diastereoselective three-component reaction has been developed for the efficient synthesis of vicinal diamine derivatives with two tertiary stereocenters in high yields (75%->95%) and high to excellent diastereoselectivities. The generated product can be easily converted to free diamines via hydrolysis of the imine motif under mild conditions.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Farrukh Sajjad, Yanmei Chen, Xue Tian, Suzhen Dong, Alavala Gopi Krishna Reddy, Wenhao Hu, Dong Xing
Summary: An efficient strategy for the construction of 1,4-oxazines from simple alpha-amino ketones and diazo pyruvates catalyzed by RuCl3 was reported, showing promising anticancer activities towards HCT116. This transformation involves a tandem N-H insertion/cyclization sequence via an enol formation under mild reaction conditions with broad functional group tolerance.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Qiyao Zheng, Hui Dong, Jianshan Mo, Yi Zhang, Jie Huang, Shumin Ouyang, Shuo Shi, Kai Zhu, Xinming Qu, Wenhao Hu, Peiqing Liu, Yuanxiang Wang, Xiaolei Zhang
Summary: Constitutive activation of STAT3 is common in NSCLC and plays a crucial role in cancer progression and acquired resistance to targeted therapies. W2014-S, a novel STAT3 inhibitor, demonstrated significant anti-tumor activities by disrupting STAT3 signaling and sensitizing resistant NSCLC cells to EGFR-TKIs in vitro and in vivo. Combining W2014-S with gefitinib could be a promising strategy to overcome EGFR-TKIs acquired resistance in NSCLC patients.
Article
Chemistry, Organic
Jiuling Li, Bin Li, Juan Chen, Xinyu Jia, Min Wang, Chengjun Hao, Xinhua Zheng, Hongmei Dai, Wenhao Hu
Summary: A series of gem-chlorosulfurization products bearing difluoromethyl substituents were synthesized directly from p-toluenesulfonyl difluorodiazoethane (TsCF2CHN2), disulfides, and PhICl2 in high to excellent yields without the need for any catalysts or additives. The products showed high functional group compatibility and could be efficiently converted to sulfur-containing and aryl substituted difluoromethyl derivatives through a feasible multi-component operation.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
