Article
Chemistry, Organic
Jie Zheng, Meng-Yu Rong, Fang-Fang Feng, Fa-Guang Zhang, Chi Wai Cheung, Jun-An Ma
Summary: In this study, the organocatalytic asymmetric aza-Friedel-Crafts-type reaction of indol-3-ones with 1- and 2-naphthols was performed using spirocyclic chiral phosphoric acids and quinine-incorporated squaramides as the organocatalysts. Two classes of structurally distinct chiral compounds, namely 2-(hydroxylnaphthyl)-indolin-3-ones and tetrahydrofuroindoles, were formed. These quaternary centre-containing indoline derivatives may have applications in the synthesis of biologically active molecules.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yuki Saito, Shu Kobayashi
Summary: The article discusses the application of chiral heterogeneous Sc catalysts in continuous-flow reactions, achieving efficient synthesis of compounds through noncovalent interactions and the crucial role of heteropoly acid.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Byungjun Kim, Sukwoo Lee, Sarah Yunmi Lee
Summary: In this study, a new method was reported to successfully promote the catalytic asymmetric Diels-Alder reactions using a chiral catalyst in conjunction with a chiral isothiourea catalyst or a Bronsted acid, resulting in the synthesis of densely functionalized cyclohexenes with multiple stereocenters.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Review
Chemistry, Organic
Anup Biswas
Summary: The aza-Friedel-Crafts reaction allows for the efficient coupling of electron-rich aromatic systems with imines, facilitating the incorporation of aminoalkyl groups into the aromatic ring. This reaction offers a wide range of forming aza-stereocenters, which can be controlled by different asymmetric catalysts. This review highlights recent advances in asymmetric aza-Friedel-Crafts reactions mediated by organocatalysts and provides mechanistic insights into the origin of stereoselectivity.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Huimiao Zhang, Patrick H. Toy
Summary: A halogen bond donor based on a 2,2'-bipyridine framework has been synthesized and used to catalyze Friedel-Crafts reactions of furans, yielding good reaction yields with moderate catalyst loading at low temperatures. The catalyst design allows for the potential development of an enantioselective version for stereo-selective catalysis.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Applied
You-Song Cheng, Shih-Hsien Chan, Gunda Ananda Rao, Ramani Gurubrahamam, Kwunmin Chen
Summary: An asymmetric organocatalytic aza-Friedel-Crafts reaction was developed to synthesize enantioenriched Delta(4)-isoxazoline scaffold with a quaternary-substituted stereogenic center in good-to-excellent yields and enantioselectivity. This protocol involves the in situ generation of isoxazolium ions in the presence of a chiral phosphoric acid followed by heteroarene addition through asymmetric counteranion-directed catalysis.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Applied
I-Ting Chen, Ren-You Guan, Jeng-Liang Han
Summary: In this study, a catalytic asymmetric vinylogous Mannich/annulation/acylation reaction was developed for the synthesis of chiral spiro-oxindole piperidine derivatives with polyaromatic scaffolds. The reaction provided the desired products in good yields and high enantioselectivity. DFT computational calculations were used to explain the mechanism and origin of the observed enantioselectivity and O-acetylated products.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Feng-Tao Sheng, Shuang Yang, Shu-Fang Wu, Yu-Chen Zhang, Feng Shi
Summary: A new strategy for the enantioselective synthesis of axially chiral 3,3'-bisindoles was developed by directly coupling two indole rings using the C3-umpolung reactivity of 2-indolylmethanols. The synthesized compounds can be further modified to create axially chiral 3,3'-bisindole-based organocatalysts for asymmetric catalysis.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Mohd Jubair Aalam, Deepa, Surendra Singh
Summary: In this study, imidazolium ionic liquids containing second-generation MacMillan catalysts were synthesized and used as organocatalysts for enantioselective Friedel-Crafts reaction. The results showed that the organocatalyst exhibited good catalytic activity and enantioselectivity towards different substrates and substituents under suitable reaction conditions. However, a decrease in catalytic activity and enantioselectivity was observed with increasing reaction cycles.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Bo-Bo Gou, Yue Tang, Yan-Hong Lin, Le Yu, Qing-Song Jian, Huai-Ri Sun, Jie Chen, Ling Zhou
Summary: A new type of chiral all-carbon tetrasubstituted VQMs was successfully prepared via nucleophilic addition of 2-alkynylnaphthols to o-quinone methides or imines, catalyzed by chiral phosphoric acids. The method showed high efficiency and excellent diastereoselectivities and enantioselectivities, leading to the synthesis of naphthyl-2H-chromenes with axially and centrally chiral elements and axially chiral quinone-naphthols. The obtained axially chiral naphthols could further be converted into valuable phosphine ligands and other functional molecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Editorial Material
Chemistry, Organic
Nimisha Bania, Dipankar Barman, Subhas Chandra Pan
Summary: An organocatalytic asymmetric oxa-Michael-Michael reaction was developed for the synthesis of spirotetrahydropyranopyrazolones. By utilizing a quinine-derived squaramide catalyst, the reaction achieved moderate yields, excellent diastereomeric ratios, and high to excellent enantioselectivities under mild reaction conditions.
Article
Chemistry, Physical
Ryoya Tajima, Takaaki Saito, Takayoshi Arai
Summary: The conventional acid-catalyzed aza-Friedel-Crafts reaction of phenols with imines typically shows ortho-selectivity. However, a chiral bis(imidazolidine) pyridine (PyBidine)-Ni(OAc)(2) catalyst can switch the regioselectivity to para-selectivity. This switch is facilitated by the bulky PyBidine-Ni(OAc)(2) catalyst with a Ph2CHCH2 substituent, resulting in highly para-selective aza-Friedel-Crafts reactions (up to 99:1 para/ortho selectivity).
Article
Chemistry, Organic
Martina Sotolova, Martin Kamlar, Marek Remes, Pierre-Yves Geant, Ivana Cisarova, Martin Sticha, Jan Vesely
Summary: An organocatalytic asymmetric domino Michael/alpha-alkylation reaction has been developed for the synthesis of 1,2,3-trisubstituted cyclopentane carbaldehydes. The reaction, catalyzed by chiral secondary amines, exhibits high diastereo- and enantioselectivities.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Esra Dundar, Cihangir Tanyeli
Summary: A series of chiral bifunctional squaramide organocatalysts were evaluated for their application in Friedel-Crafts alkylation of indoles, showing high enantioselectivity and moderate yields. This new asymmetric transformation provides a simple, efficient, clean, and environmentally friendly route for chemical synthesis.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Organic
Sk Md Samim Akhtar, Sukanta Bar, Saumen Hajra
Summary: A proficient stereoselective aminoarylation reaction of N-cinnamylanilines was developed based on a two-step protocol involving catalytic enantioselective aziridination and subsequent 6-endo-tet Friedel-Crafts cyclization. The reaction showed excellent diastereo- and enantioselectivity in the synthesis of trans-3-amino-4-aryltetrahydroquinolines, with the potential for concise synthesis of bioactive compounds.
Article
Engineering, Environmental
Novitri Hastuti, Kyohei Kanomata, Takuya Kitaoka
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2018)
Article
Engineering, Environmental
Chaniga Chuensangjun, Kyohei Kanomata, Takuya Kitaoka, Yusuf Chisti, Sarote Sirisansaneeyakul
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2019)
Article
Biochemistry & Molecular Biology
Naliharifetra Jessica Ranaivoarimanana, Kyohei Kanomata, Takuya Kitaoka
Article
Chemistry, Multidisciplinary
Kyohei Kanomata, Yuki Nagasawa, Yukihiro Shibata, Masahiro Yamanaka, Fuyuki Egawa, Jun Kikuchi, Masahiro Terada
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Kyohei Kanomata, Naoya Fukuda, Takuma Miyata, Pui Ying Lam, Toshiyuki Takano, Yuki Tobimatsu, Takuya Kitaoka
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2020)
Review
Chemistry, Multidisciplinary
Yoshihiro Sohtome, Kyohei Kanomata, Mikiko Sodeoka
Summary: The review outlines the rapid expansion in the scope of cross-coupling reactions involving tertiary carbon-centered radicals over the past decade, with a focus on the reactivity and selectivity relationships of persistent tertiary carbon-centered radicals derived from carbonyl- or related compounds. Selected recent examples of cross-coupling reactions are presented to demonstrate their versatility as a synthetic tool for structural diversification of small molecules.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2021)
Article
Chemistry, Organic
Izuru Tsuchimochi, Shuhei Hori, Yasuo Takeuchi, Masahiro Egi, Tomo-o Satoh, Kyohei Kanomata, Takashi Ikawa, Shuji Akai
Summary: This study successfully carried out four different reactions (1,3-migration of a hydroxy group, kinetic resolution, racemization, and an intramolecular Diels-Alder reaction) from readily available tertiary alcohols in a one-pot process with high yields and high enantioselectivities, under the co-catalysis of lipase and oxovanadium compounds. The key discovery was that a silyl group attached to the vinyl moiety's terminal carbon controlled the direction of hydroxy group migration.
Article
Chemistry, Organic
Tomoya Nishio, Shin Yoshioka, Kai Hasegawa, Kenzo Yahata, Kyohei Kanomata, Shuji Akai
Summary: The direct nucleophilic substitution of alcohols with thiols or carbon nucleophiles was achieved using a mesoporous silica-supported oxovanadium catalyst (VMPS4). The VMPS4 catalyst exhibited excellent chemoselectivity towards alcohols and could be easily recycled through simple centrifugation.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Materials Science, Paper & Wood
Novitri Hastuti, Hendrik Setiawan, Kyohei Kanomata, Takuya Kitaoka
Summary: This study investigates the integration of nanocellulose into an alginate matrix to enhance water-ethanol separation. The results indicate that incorporating nanocellulose derived from oil palm waste improves the water adsorption capacity of the membrane.
CELLULOSE CHEMISTRY AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Satoshi Horino, Tomoya Nishio, Shinji Kawanishi, Shinya Oki, Koichi Nishihara, Takashi Ikawa, Kyohei Kanomata, Karla Wagner, Harald Groeger, Shuji Akai
Summary: In this study, a method for obtaining S enantiomers from secondary 3-(trialkylsilyl)propargyl alcohols was achieved by using a well-known R-selective Pseudomonas fluorescens lipase in combination with a racemization catalyst VMPS4, in which the silyl group reverses the size relationship of substituents near the carbinol moiety. Immobilization of the lipase on Celite was found to be important for achieving a high efficiency of the dynamic kinetic resolution.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Physical
Jihoon Moon, Takusho Kin, Karin Mizuno, Shuji Akai, Kyohei Kanomata
Summary: This study presents a chemoenzymatic dynamic kinetic resolution (DKR) of racemic sec-alcohols using immobilized lipase and aqueous sulfuric acid as catalysts for kinetic resolution and racemization, respectively. The use of nanoparticle-stabilized phase separation in a Pickering emulsion allowed the use of these incompatible catalysts in a single vessel. The racemization reaction in the aqueous sulfuric acid solution effectively suppressed side reactions, resulting in high yields and optical purities.
Article
Chemistry, Organic
Makoto Sako, Kyohei Kanomata, Mohamed S. H. Salem, Tomohiro Furukawa, Hiroaki Sasai, Shinobu Takizawa
Summary: The nucleophilic addition and aryl migration of triarylphosphines to alkynyl esters in the presence of water leads to the formation of 3-(diarylphosphoryl)-3-aryl propanoic acid derivatives through a metal-free C(aryl)-P bond cleavage process. Experimental and computational investigations demonstrate that the rapid formation of hydroxy-lambda(5)-phosphane as a key intermediate plays a crucial role in facilitating the smooth C(aryl)-P bond cleavage.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Kengo Kasama, Kyohei Kanomata, Yuya Hinami, Karin Mizuno, Yuta Uetake, Toru Amaya, Makoto Sako, Shinobu Takizawa, Hiroaki Sasai, Shuji Akai
Summary: A new chemical reaction was successfully achieved by using a mesoporous silica-supported oxovanadium catalyst.
Article
Chemistry, Multidisciplinary
Naliharifetra Jessica Ranaivoarimanana, Xin Habaki, Takuya Uto, Kyohei Kanomata, Toshifumi Yui, Takuya Kitaoka
Article
Chemistry, Multidisciplinary
Yusaku Hirayama, Kyohei Kanomata, Mayumi Hatakeyama, Takuya Kitaoka