期刊
SYNLETT
卷 -, 期 16, 页码 2359-2362出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1260313
关键词
glycosylation; carbohydrates; stereoselective synthesis; carbocation; natural products
资金
- JSPS/MEXT [22310136, 21106008, 23241074, 20-870]
- Osaka University
- Naito Foundation
- JSPS [LR025]
- CSTP
- Grants-in-Aid for Scientific Research [23241074, 22310136, 21106008] Funding Source: KAKEN
A practical and efficient stereoselective synthesis of 3-deoxy-D-manno-2-octulosonic acid (Kdo) glycoside was achieved using N-trifluoroacetoimidate as the glycosyl donor with both batch and microfluidic methods. The method used a conformationally constrained glycosyl donor, which has a bulky isopropylidene group at the 4,5-O-position. The strained conformation directed the coordination of the acetonitrile solvent, which led to the enhancement of reactivity and alpha-selectivity in the glycosylation.
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