Biosynthesis of Resveratrol Dimers by Regioselective Oxidative Coupling Reaction

A wide array of natural resveratrol dimers was prepared by the regioselective oxidative coupling reaction of 3,5-di-(tert-butyl) resveratrol using several types of metal oxidants (Ag(2)O, Ag(2)CO(3), MnO(2), and FeCl(3)center dot 6H(2)O) in different solvent systems (benzene-acetone and dichloromethane). Subsequent debutylation of these coupling products resulted in racemic pallidol and ampelosin F.