Article
Chemistry, Applied
Gonzalo Vera, Reynald Mangeant, Silvia Stiebing, Yohann Berhault, Frederic Fabis, Thomas Cailly, Valerie Collot
Summary: A site-selective and thiol-free thiofunctionalization of electron-rich heteroarenes was reported in this study. By conducting a selective ortho-magnesiation and using S-8, direct access to S-alkyl or -aryl derivatives was achieved, followed by in situ oxidation to provide sulfoxide and sulfone derivatives. Using this protocol, Cerlapirdine was synthesized in 4 steps with an overall yield of 28%.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Mario Andres Gomez Fernandez, Corentin Lefebvre, Alexander Sudau, Pierre Genix, Jean-Pierre Vors, Manabu Abe, Norbert Hoffmann
Summary: This study explores the Paterno-Buchi reactions between heteroaromatics, trifluoromethylphenyl ketone, and electron-rich alkenes to form oxetanes. A comprehensive investigation is conducted on the reaction of aromatic ketones with fluorinated alkenes. The results explain the regioselectivity and open perspectives for oxetanes as core structures for biologically active compounds.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Giovanni M. Fusi, Zelong Lim, Stephen D. Lindell, Enrique Gomez-Bengoa, Malcolm R. Gordon, Silvia Gazzola
Summary: This study demonstrates that the isomerization of purin-2- and 6-yl Grignards to 8-yl Grignards can be stopped by conducting the reaction in dichloromethane (DCM), allowing direct reactions with various aldehydes. In addition, functionalization of purine with ketones has been achieved with the presence of LaCl3·2LiCl. Density functional theory calculations provide an explanation for the role of solvent in this chemistry, indicating that the polarity of the C-Mg bond is influenced by the solvent.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Camila R. S. Bertallo, Leonardo S. Berlim, Danilo S. Olivier, Thais R. Arroio, Amando S. Ito, Giuliano C. Clososki
Summary: In this study, 20 novel fluorescent 5-carbonylated 2-arylindolizines derivatives were synthesized through the reaction between organolithium intermediates with different electrophiles. The photophysical properties, including electronic absorption spectra, fluorescence emission, quantum yield, and Stokes shift, were evaluated to investigate the effects of substituents. The results showed variations in absorbance peaks, fluorescence emission, decay times, quantum yield values, and Stokes shifts, with DFT calculations also performed for further analysis.
Article
Chemistry, Organic
E. H. Nisala Fernando, Jose Cortes Vazquez, Jacqkis Davis, Weiwei Luo, Vladimir N. Nesterov, Hong Wang
Summary: The formation of enamine from primary arylamines was studied and confirmed, with the necessity of a radical quencher for detection. A direct synthesis of alpha-enaminones from primary arylamines and ketones was developed, and a mechanistic investigation suggested the involvement of an amine radical cation. The reactivity and utility of alpha-enaminones were explored, showing different properties from enamines and advancing understanding in organic chemistry.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Artem P. Dysin, Anton R. Egorov, Omar Khubiev, Roman Golubev, Anatoly A. Kirichuk, Victor N. Khrustalev, Nikolai N. Lobanov, Vasili V. Rubanik, Alexander G. Tskhovrebov, Andreii S. Kritchenkov
Summary: In this study, new Cu(II)/chitosan-based systems were designed and evaluated for their catalytic properties in various organic transformations. The use of different treatments and coatings resulted in efficient catalysts for different types of reactions. The reactions were conducted in water and the product was easily isolated from the catalyst.
Article
Chemistry, Applied
Tianlong Zeng, Jingyang Kong, Hongkai Wang, Lingyan Liu, Weixing Chang, Jing Li
Summary: Substituent-controlled divergent cascade cycloaddition reactions of chalcones and arylalkynols in the presence of PtI2 were reported, yielding either spiroketals or oxa-bridged fused heterocycles depending on the substituent on the chalcone. Control experiments elucidated the high chemoselectivity, providing a method for the synthesis of a diverse array of structurally complex oxygen-containing heterocycles.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Ekaterina A. Lystsova, Maksim V. Dmitriev, Andrey N. Maslivets, Ekaterina E. Khramtsova
Summary: A new synthetic approach to pyrrolobenzothiazoles is developed based on 1,4-thiazine ring contraction in 3-aroylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones under the action of nucleophiles. The proposed approach works well with alkanols, benzylamine, and arylamines. The synthesized pyrrolobenzothiazole derivatives represent an interest to pharmaceutics for targeted cancer therapy development.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Rui Chang, Yubing Pang, Juntao Ye
Summary: This study reports a photoinduced approach for hydroarylation of unactivated olefins using 4-hydroxycoumarins as the arylating reagent. The key to the success of this reaction is the conversion of nucleophilic 4-hydroxycoumarins into electrophilic carbon radicals through photocatalytic arene oxidation. This method not only overcomes the polarity-mismatch issue encountered under ionic conditions but also allows for a broad substrate scope and inhibits side reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Tsukasa Tawatari, Ritsuki Kato, Riku Kudo, Kiyosei Takasu, Hiroshi Takikawa
Summary: In this study, we report on the intramolecular (3+2) cycloaddition reactions between ynamides and benzyne. These reactions involve the formation of two bonds and are facilitated by using benzyne precursors containing a chlorosilyl group. The intermediate indolium ylide in these reactions exhibits both nucleophilic and electrophilic properties at its C2 atom.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yi Gong, Cai Wang, Feng Zhou, Kui Liao, Xi-Yu Wang, Ying Sun, Yan-Xue Zhang, Zhi Tu, Xin Wang, Jian Zhou
Summary: This study presents the first highly selective kinetic resolution of racemic alpha-chiral azides through Cu-catalyzed azide-alkyne cycloaddition (CuAAC). Newly developed pyridine-bisoxazoline (PYBOX) ligands bearing a C4 sulfonyl group enabled effective kinetic resolution and asymmetric CuAAC of racemic azides derived from privileged scaffolds such as indanone, cyclopentenone, and oxindole, leading to alpha-tertiary 1,2,3-triazoles with high to excellent ee values. DFT calculations and control experiments revealed that the C4 sulfonyl group decreased the Lewis basicity of the ligand and increased the electrophilicity of the copper center for better recognition of azides, while also functioning as a shielding group to enhance the efficacy of the chiral pocket of the catalyst.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Hao Fu, Dan Yang, Di Qiu, Chun Hua Yan, Ren Cai, Yaping Du, Weihong Tan
Summary: A facile colloidal chemistry method is reported to obtain three-dimensional supercuboids from two-dimensional ZnSe nanosheets. The highly stable supercuboids can be readily transformed back to nanosheets through an exfoliation process. The potential application of ZnSe nanosheets in catalysis is demonstrated in the aldol condensation reaction.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Organic
Shi-Yi Zhuang, Jin-Yi Liu, Hui Guo, Yong-Xing Tang, Xiang-Long Chen, Jin-Tian Ma, Yan-Dong Wu, An-Xin Wu, Kai-Lu Zheng
Summary: A metal-free multicomponent cascade annulation reaction using an I2-DMSO mediator has been developed, which involves trifunctionalization of the substrate and cleavage of bonds to obtain pyrrolo[2,1-a]isoquinoline derivatives with a quaternary carbon center.
Article
Chemistry, Physical
Kennosuke Itoh, Nanase Ishii, Atsushi Takashino, Aya Hara, Satoshi Kon, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Yoshio Shibagaki, Kenichiro Nagai, Noriko Sato, Ken Tokunaga, Mitsuaki Suzuki, Masashi Hashimoto, Hideaki Fujii
Summary: In this study, a new method for synthesizing pharmacological drugs using a photosensitizer was proposed. The study showed that imidazolidines can be synthesized through a photocycloaddition reaction under specific conditions. A reaction mechanism was proposed based on quenching experiments, quantum yield, and potential measurements.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Hui-Rong Lu, Hui Geng, Guan-Tian Ding, Pei-Qiang Huang
Summary: We report a catalyst- and solvent-free method to synthesize enantioenriched secondary amides. The method is simple, mild, versatile, and efficient with high selectivity, and can be applied to different types of asymmetric products and alpha-branched primary amines.
Editorial Material
Pediatrics
Katherine Brown, John Pappachan, Martin McKee
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Health Care Sciences & Services
Martin McKee, Olivier J. Wouters
Summary: Regulation of health technologies, especially artificial intelligence in healthcare, needs to be rigorous to build trust. This commentary outlines the scope and challenges regulators face in dealing with AI applications in healthcare. It is crucial for the regulatory environment to keep up with the fast-evolving healthcare industry to anticipate and prevent potential risks.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2023)
Editorial Material
Public, Environmental & Occupational Health
Martin McKee, Anthony Staines
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Manuel Serrano-Alarcon, Yuxi Wang, Alexander Kentikelenis, Martin Mckee, David Stuckler
Summary: This study examines the association between far-right politics and vaccine hesitancy during the COVID-19 vaccine roll-out in Spain. The findings show that far-right supporters were initially more vaccine-hesitant, but this decreased with a successful vaccine roll-out. However, vaccine hesitancy rebounded among far-right voters when their party leaders promoted anti-vax discourse.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Lucinda Hiam, Danny Dorling, Martin McKee
Summary: This study explores the views of public health experts on the adverse trends in life expectancy in England and Wales over the past decade, their causes and possible solutions, as well as their opinions on how the pre-pandemic situation influenced the UK's COVID-19 response. The findings show a lack of consensus among experts on the significance and explanations of the decline in life expectancy during this period. Some attributed it to data misinterpretation, widening health inequalities, and disinvestment in public services, while others emphasized social factors. The majority called for increased investment and implementation of existing evidence on reducing health inequalities, highlighting the need to address these underlying issues for pandemic preparedness.
Article
Health Care Sciences & Services
Peter Binyaruka, Antonio Andreoni, Dina Balanova, Martin Mckee, Eleanor Hutchinson, Blake Angell
Summary: This study examined the preferences of health providers for policy interventions to address informal payments in Tanzania using a discrete choice experiment. The results showed that health providers generally preferred incentive payments for non-infraction and opportunities for private practice, but disliked disciplinary measures. Preferences varied across different groups, suggesting the need for tailored interventions.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2023)
Article
Public, Environmental & Occupational Health
Jonathan Cylus, Jessica Walters, Martin McKee, Peter Cowley
Summary: Covid-19 vaccination rollouts not only save lives and relieve pressures on health systems but also support economic growth and generate additional tax revenues. Meeting the 85% adult population target can partially offset the costs of vaccine programs by increasing consumption tax revenues.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Editorial Material
Medicine, General & Internal
Lucinda Hiam, Danny Dorling, Martin McKee
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
(2023)
Article
Medicine, General & Internal
Sharon Friel, Jeff Collin, Mike Daube, Anneliese Depoux, Nicholas Freudenberg, Anna B. Gilmore, Paula Johns, Amos Laar, Robert Marten, Martin McKee, Melissa Mialon
Summary: This paper discusses the future role of the commercial sector in global health and health equity. It does not propose the overthrow of capitalism or full support for corporate partnerships. There is no single solution to eliminate the harms caused by commercial determinants of health, but evidence suggests that progressive economic models, international frameworks, government regulation, compliance mechanisms, and strategic civil society mobilisation can collectively bring about systemic, transformative change to reduce these harms and promote human and planetary wellbeing. The question is not whether the world has the resources or will to act, but whether humanity can survive without making these efforts.
Article
Economics
Gabor Scheiring, Aytalina Azarova, Darja Irdam, Katarzyna Doniec, Martin McKee, David Stuckler, Lawrence King
Summary: An unprecedented mortality crisis occurred in Eastern Europe during the 1990s, resulting in around seven million excess deaths. This study examines the relationship between deindustrialization and mortality in Eastern Europe and proposes a theoretical framework that identifies deindustrialization as a process of social disintegration caused by shock therapy. The findings show that deindustrialization directly influenced male mortality rates and was indirectly mediated by hazardous drinking as a coping strategy.
CAMBRIDGE JOURNAL OF ECONOMICS
(2023)
Article
Medicine, General & Internal
Peter Binyaruka, Blake Angell, Martin McKee, Antonio Andreoni, Masuma Mamdani, Eleanor Hutchinson, Dina Balabanova
Summary: This study developed a discrete choice experiment (DCE) to address informal payments in the health sector in Tanzania. Through a mixed-methods approach, the researchers identified six attributes for the DCE and validated them through a pilot study. The findings provide important insights for policy interventions.
Editorial Material
Medicine, General & Internal
Martin Mckee
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Mark A. Green, Martin McKee, Olivia K. L. Hamilton, Richard J. Shaw, John Macleod, Andy Boyd, Srinivasa Vittal Katikireddi
Summary: This study examined the association between disrupted access to healthcare during the covid-19 pandemic and the risk of avoidable hospital admissions. The findings showed that people who experienced disrupted access had a higher likelihood of potentially preventable hospital admission. This highlights the importance of increasing healthcare investment to address the implications of the pandemic and protect treatments and procedures during future pandemics.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Review
Health Care Sciences & Services
Alexander Kentikelenis, Abdul Ghaffar, Martin McKee, Livia Dal Zennaro, David Stuckler
Summary: Health policy and systems research (HPSR) is a neglected area in global health financing, with only 2% of funding calls including a discernible HPSR component. Efforts should be made to convince global health funders to institutionalize the inclusion of HPSR components in all funding calls.
HEALTH POLICY AND PLANNING
(2023)
Article
Medicine, General & Internal
Lucinda Hiam, Theodore Estrin-Serlui, Danny Dorling, Martin Mckee, Jon Minton
Summary: The number of deaths occurring in private homes in England and Wales, particularly from 2020, has been increasing rapidly. Media reports and research have linked decomposing bodies found in private homes with pandemic-related social isolation. This study aims to determine whether these incidents are isolated or part of a larger trend.
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
(2023)
