Article
Oncology
Allison Staley, Katherine Tucker, Yajie Yin, Xin Zhang, Yali Fan, Yingao Zhang, Ziwei Fang, Wenchuan Sun, Hongyan Suo, Xiaoling Zhao, Ziyi Zhao, Varun Vijay Prabhu, Joshua E. Allen, Chunxiao Zhou, Victoria L. Bae-Jump
Summary: ONC206 demonstrates greater potency than ONC201 in inhibiting proliferation of EC cells by inducing cellular stress, apoptosis, and G1 phase cell cycle arrest. Additionally, ONC206 inhibits EC tumor growth in both obese and lean mice, showing potential clinical value for treatment of endometrial cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Anna Kruyer, Jeffrey Parrilla-Carrero, Courtney Powell, Lasse Brandt, Stefan Gutwinski, Ariana Angelis, Reda M. Chalhoub, Thomas C. Jhou, Peter W. Kalivas, Davide Amato
Summary: Antipsychotic-induced dopamine supersensitivity is a problematic consequence of long-term antipsychotic treatment, characterized by motor abnormalities, refractory symptoms, and rebound psychosis. This phenomenon is associated with long-lasting synaptic plasticity and hyperexcitability in a subpopulation of D2 receptor-expressing neurons, leading to behavioral endophenotypes of treatment resistance and substance use disorder. Chemogenetic restoration of inhibitory postsynaptic currents may offer a novel therapeutic direction for preventing antipsychotic-induced supersensitivity.
MOLECULAR PSYCHIATRY
(2021)
Article
Cell Biology
Xiao-Yu Liu, Li-Fei Zheng, Yan-Yan Fan, Qian-Ying Shen, Yao Qi, Guang-Wen Li, Qi Sun, Yue Zhang, Xiao-Yan Feng, Jin-Xia Zhu
Summary: In this study, the researchers investigate the effect of dopamine on gastric pepsinogen secretion through dopamine receptors expressed on chief cells or potential D2 receptors expressed on D cells. The findings suggest that dopamine promotes gastric pepsinogen secretion directly through D1-like receptors on chief cells and indirectly through D2 receptor-mediated suppression of somatostatin release.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yarim Elideth De la Luz-Cuellar, Ulises Coffeen, Francisco Mercado, Vinicio Granados-Soto
Summary: This study investigated the impact of sex on the antiallodynic activity of spinal dopamine D1 and D2-like receptors in a model of fibromyalgia-type pain in rats. The results showed that drugs targeting these receptors had a greater effect on female rats compared to male rats. Sex differences were also observed in a nerve injury model. These findings suggest that the antiallodynic effect of dopamine receptors in fibromyalgia-type pain is influenced by hormonal receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Richard B. Mailman, Yang Yang, Xuemei Huang
Summary: Research suggests that selective D-1 agonists may play a critical role in the treatment of Parkinson's disease, providing profound symptomatic relief even when current drugs are ineffective. Existing Parkinson's medications have limited efficacy in severe cases, but high intrinsic activity D-1 agonists could offer a major therapeutic advance in improving patients' quality of life.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ginna Uruena-Mendez, Andrea Dimiziani, Lidia Belles, Raphael Goutaudier, Nathalie Ginovart
Summary: Current research suggests that alterations in dopamine transmission in the striatum contribute to impulsivity and novelty-seeking, and may be related to a higher susceptibility to drug abuse. However, there is still debate about whether this susceptibility results from a hyperdopaminergic or hypodopaminergic state. In this study, rats with high impulsivity and novelty-seeking behaviors exhibited lower availability of D2/3 receptors and higher amphetamine-induced dopamine release in the striatum, which predicted higher levels of cocaine intake. Cocaine self-administration did not affect D2/3 receptor availability or impulsivity in these rats. Importantly, cocaine exposure led to a baseline-dependent decrease in stimulated dopamine release in high-impulsive/high novelty-seeking rats only, and to a baseline-dependent increase in novelty-seeking in low-impulsive/low novelty-seeking rats only. Overall, this study suggests that susceptibility to drug abuse is associated with an innate hyper-responsive dopamine system that promotes impulsive and novelty-seeking behaviors, and leads to stronger initial drug-reinforcing effects. However, with repeated cocaine use, tolerance to drug-induced dopamine elevations develops, resulting in compensatory increases in drug consumption to overcome reduced reward effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
B. F. G. Queiroz, F. C. S. Fonseca, R. C. M. Ferreira, T. R. L. Romero, A. C. Perez, I. D. G. Duarte
Summary: This study investigated the role of dopamine and its receptors in the peripheral processing of the nociceptive response in mice using a pharmacological approach and the paw pressure test. The results showed that dopamine at small doses produced antinociceptive effects via the activation of D-2-like receptors, while at higher doses it caused hyperalgesia via the activation of D-1-like receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Leili Mortazavi, Tristan J. Hynes, Chloe S. Chernoff, Shrishti Ramaiah, Hannah G. Brodie, Brittney Russell, Brett A. Hathaway, Sukhbir Kaur, Catharine A. Winstanley
Summary: Dopamine agonist therapies used to treat Parkinson's disease can exacerbate impulse control and gambling disorders, but the underlying mechanisms are unclear. Recent studies have found that adding win-paired cues to the rat gambling task increases risky decision-making and impulsivity via the dopamine system. Ropinirole treatment in male rats transiently increased motor impulsivity and choice of high-risk/high-reward options, especially during acquisition of the cued gambling task. The drug enhanced model-free learning and suppressed the activity of dopaminergic midbrain neurons, leading to perpetuated risky choice.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Katina C. Calakos, Aleksandra Rusowicz, Brian Pittman, Jean-Dominique Gallezot, Marc N. Potenza, Kelly P. Cosgrove, David Matuskey
Summary: Social factors are associated with psychiatric outcomes and brain function. This study found that living in a populous area with fewer educational resources may lead to higher availability of dopamine D2/3 receptors. This suggests that the social environment has an impact on an individual's brain function.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Lidia Belles, Andrea Dimiziani, Francois R. Herrmann, Nathalie Ginovart
Summary: Our study suggests that the early rearing environment influences impulsivity and novelty preference, as well as striatal dopamine D-2/3-receptor availability and amphetamine-induced dopamine release. Rats raised in enriched environments showed a higher propensity for drug addiction and increased dopamine release. The correlation between impulsivity, novelty preference, D-2/3-receptor availability, and dopamine release is affected by environmental factors.
PSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Lidia Belles, Andrea Dimiziani, Stergios Tsartsalis, Philippe Millet, Francois R. Herrmann, Nathalie Ginovart
Summary: The study revealed a strong relationship between impulsivity and novelty preference in rats. The availability of D2/3 receptors in the striatum is closely associated with these traits, while dopamine release in both ventral and dorsal striatum further impacts this correlation.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Bai-Lin Song, Jie Zhou, Yi Jiang, Lai-Fu Li, Ying-Juan Liu
Summary: The dopamine system and the lateral septum play important roles in social hierarchies. Mice living in social groups form linear dominance hierarchies, with subordinates showing increased anxiety. D2 receptors in the intermediate region of the lateral septum are elevated in subordinates, and pharmacological studies show that simultaneous D2 receptor activation in dominants and inhibition in subordinates can switch the original dominant-subordinate relationship.
Review
Psychiatry
Vanja Mandic-Maravic, Roberto Grujicic, Luka Milutinovic, Ana Munjiza-Jovanovic, Milica Pejovic-Milovancevic
Summary: Autism spectrum disorders (ASD) are characterized by impairment in social communication and repetitive behaviors. The causes of ASD are complex, involving both genetic and environmental factors. Current treatments only target the non-specific symptoms, and no specific treatment for the core symptoms of ASD has been developed.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Oncology
Anna K. Laskowska, Mateusz Szudzik, Aneta Sciezynska, Michal Komorowski, Edina Szucs, David Gombos, Bartlomiej Baczek, Jowita Lipka-Miciuk, Sandor Benyhe, Patrycja Kleczkowska
Summary: Pancreatic cancer is difficult to treat and current medications have serious side effects. This study evaluated the anticancer effects of ranatensin, a naturally occurring peptide, and found that it may affect cancer cells through different receptors. Despite this, the peptide may be a potential effective agent for cancers expressing specific receptors.
Article
Neurosciences
Bo Xing, Nancy R. Mack, Yu-Xiang Zhang, Erin P. McEachern, Wen-Jun Gao
Summary: Neuronal activity in the prefrontal cortex (PFC) controls dominance hierarchies, and dopamine plays a key role through D1 and D2 receptors. D1R+ neurons determine dominance while D2R+ neurons determine subordination. The synaptic strengths of D1R+ neurons and neuronal excitability of D2R+ neurons are important factors in intermale social rank determination.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Christopher T. Smith, Jennifer L. Crawford, Linh C. Dang, Kendra L. Seaman, M. Danica San Juan, Aishwarya Vijay, Daniel T. Katz, David Matuskey, Ronald L. Cowan, Evan D. Morris, David H. Zald, Gregory R. Samanez-Larkin
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
Article
Neurosciences
Jaime J. Castrellon, Kendra L. Searnan, Jennifer L. Crawford, Jacob S. Young, Christopher T. Smith, Linh C. Dang, Ming Hsu, Ronald L. Cowan, David H. Zald, Gregory R. Samanez-Larkin
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Christopher T. Smith, Linh C. Dang, Leah L. Burgess, Scott F. Perkins, M. Danica San Juan, Darcy K. Smith, Ronald L. Cowan, Nam T. Le, Robert M. Kessler, Gregory R. Samanez-Larkin, David H. Zald
PSYCHOPHARMACOLOGY
(2019)
Article
Neurosciences
Kendra L. Seaman, Christopher T. Smith, Eric J. Juarez, Linh C. Dang, Jaime J. Castrellon, Leah L. Burgess, M. Danica San Juan, Paul M. Kundzicz, Ronald L. Cowan, David H. Zald, Gregory R. Samanez-Larkin
HUMAN BRAIN MAPPING
(2019)
Article
Nursing
Sebastian W. Atalla, Laura Beth Kalvas, Jenna L. Campbell, Alison R. Anderson, Ronald L. Cowan, Kathy Wright, Angela C. Humbel, Todd B. Monroe
Article
Nursing
Sebastian W. Atalla, Ronald L. Cowan, Alison R. Anderson, Mary S. Dietrich, Larkin Iversen, Laura Beth Kalvas, Karen O. Moss, Kathy Wright, Todd B. Monroe
Summary: This study aims to examine sex- and age-associated differences in pain processing across the adult lifespan using psychophysics and functional magnetic resonance imaging methods. Understanding these differences will help improve personalized pain medicine for older adults, reducing the risk of poor pain management and associated negative impacts on quality of life and healthcare costs.
JOURNAL OF ADVANCED NURSING
(2021)
Article
Neurosciences
Raymond R. Romano, Michael A. Carter, Mary S. Dietrich, Ronald L. Cowan, Stephen P. Bruehl, Todd B. Monroe
Summary: The study found that cognitively healthy individuals with the APOE4 gene exhibit differences in pain sensitivity to experimentally-induced stimuli and experience greater levels of unpleasantness. These results suggest that altered evoked pain perception could potentially be used as a phenotypic biomarker of late-onset AD risk prior to disease onset.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Health Care Sciences & Services
Alison R. Anderson, W. Larkin Iversen, Michael A. Carter, Karen O. Moss, Ronald L. Cowan, Todd B. Monroe
Summary: Experimental studies using psychophysics show that individuals with Alzheimer's disease (AD) experience pain similarly to or more unpleasantly than cognitively intact older adults, despite cognitive impairment. This suggests amplified pain unpleasantness in people with AD. Best practices for pain assessment and management in AD should include a combination of patient reports, caregiver/surrogate reports, medical record review, analgesic trials, and regular reassessments.
JOURNAL OF THE AMERICAN ASSOCIATION OF NURSE PRACTITIONERS
(2022)
Review
Nursing
Wm. Larkin Iversen, Ronald L. Cowan, Sebastian Atalla, Sydney S. Englehart, Tanya R. Gure, Karen O. Moss, Claire M. Ryan, Douglas W. Scharre, Kathy D. Wright, Todd B. Monroe
Summary: The manuscript summarizes research on how experimental pain is experienced by adults with Alzheimer's disease and translates results into implications for nurses through discussing clinical vignettes and introducing research-related psychophysics. It emphasizes the importance of exploring pain characteristics in AD that differ from cognitively intact controls to provide high quality care to this population. Nurses are encouraged to consider research methodology and address pain issues in adults with AD.
Article
Anesthesiology
Paul A. Beach, Angela Humbel, Mary S. Dietrich, Stephen Bruehl, Ronald L. Cowan, Karen O. Moss, Todd B. Monroe
Summary: This study compared thermal pain sensitivity between patients with vascular dementia (VaD) and healthy controls, finding that while pain thresholds did not differ significantly, unpleasantness ratings were higher in the VaD group. These results suggest that VaD may increase sensitivity to pain affect.
Article
Endocrinology & Metabolism
Elizabeth Roof, Cheri L. Deal, Shawn E. McCandless, Ronald L. Cowan, Jennifer L. Miller, Jill K. Hamilton, Elizabeth R. Roeder, Shana E. McCormack, Tamanna R. Roshan Lal, Hussein D. Abdul-Latif, Andrea M. Haqq, Kathryn S. Obrynba, Laura C. Torchen, Alaina P. Vidmar, David H. Viskochil, Jean-Pierre Chanoine, Carol K. L. Lam, Melinda J. Pierce, Laurel L. Williams, Lynne M. Bird, Merlin G. Butler, Diane E. Jensen, Susan E. Myers, Oliver J. Oatman, Charumathi Baskaran, Laura J. Chalmers, Cary Fu, Nathalie Alos, Scott D. McLean, Ajay Shah, Barbara Y. Whitman, Brent A. Blumenstein, Sarah F. Leonard, Jessica P. Ernest, Joseph W. Cormier, Sara P. Cotter, Davis C. Ryman
Summary: In this study, researchers found that intranasal carbetocin, an analog of oxytocin, was safe and effective in treating symptoms of PWS, especially in reducing hyperphagia and anxiety and distress behaviors. Although the enrollment was prematurely stopped due to the COVID-19 pandemic, the results suggest that intranasal carbetocin is a promising therapy for PWS.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Meeting Abstract
Clinical Neurology
Michelle D. Failla, Ted Dimitrov, Larkin Iversen, Rachel Romestan, Asvena Siva, Ronald L. Cowan, Todd B. Monroe
Meeting Abstract
Clinical Neurology
Alison Anderson, Todd B. Monroe, Mary S. Dietrich, Stephen P. Bruehl, Larkin Iversen, Ronald L. Cowan, Michelle Failla
Article
Gerontology
Eric J. Juarez, Jaime J. Castrellon, Mikella A. Green, Jennifer L. Crawford, Kendra L. Seaman, Christopher T. Smith, Linh C. Dang, David Matuskey, Evan D. Morris, Ronald L. Cowan, David H. Zald, Gregory R. Samanez-Larkin
PSYCHOLOGY AND AGING
(2019)
Meeting Abstract
Clinical Neurology
Rawan Tarawneh, Ronald L. Cowan, Sebastian Atalla, Todd Monroe
ANNALS OF NEUROLOGY
(2019)
Article
Neurosciences
E. A. Kelly, T. M. Love, J. L. Fudge
Summary: Dopamine is involved in stress-related illnesses, and corticotropin-releasing factor plays a role in stress responses. This study examined the synaptic terminals between dopamine and non-dopamine cells and found that dopamine regulation may occur indirectly through contacts with non-dopamine neurons.
