Article
Clinical Neurology
Martin J. Lan, Francesca Zanderigo, Spiro P. Pantazatos, M. Elizabeth Sublette, Jeffrey Miller, R. Todd Ogden, J. John Mann
Summary: Disturbance of serotonin system function is associated with both the diagnosis of BD and its severity of depression. Pretreatment 5HT1AR binding did not predict SSRI antidepressant outcome.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Allison S. Cohen, Joe Grudzinski, Gary T. Smith, Todd E. Peterson, Jennifer G. Whisenant, Tiffany L. Hickman, Kristen K. Ciombor, Dana Cardin, Cathy Eng, Laura W. Goff, Satya Das, Robert J. Coffey, Jordan D. Berlin, H. Charles Manning
Summary: PET imaging using C-11-glutamine is safe and effective for noninvasively visualizing metastatic colon cancer lesions in multiple organs, providing potential utility for cancer imaging and monitoring treatment response.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Hugo Helbert, Ines Farinha Antunes, Gert Luurtsema, Wiktor Szymanski, Ben L. Feringa, Philip H. Elsinga
Summary: This study presents the cross-coupling of aryl bromides with [C-11]CH3Li for labelling various tracers for PET imaging. The radiolabelled products were obtained in high yields at room temperature and short reaction times, compatible with the short half-life of C-11. Investigating the automation of this protocol on a synthesis module is seen as a crucial step towards a rapid method for synthesizing C-11-labelled compounds for PET imaging.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Cynthia M. Co, Aditi Mulgaonkar, Ning Zhou, Shelby Harris, Orhan K. Oz, Liping Tang, Xiankai Sun
Summary: The increasing prevalence of invasive fungal infections (IFIs) has led to a greater need for rapid diagnosis. A radiotracer derived from D-amino acids (DAAs) shows promise as a more accurate way to detect bacterial and fungal pathogens. This study demonstrates the potential of D-[5-11C]-glutamine as a radiotracer for noninvasive PET imaging of IFIs.
ACS INFECTIOUS DISEASES
(2022)
Article
Chemistry, Medicinal
Shuhei Takatani, Tsuyoshi Tahara, Mieko Tsuji, Daiki Ozaki, Nina Shibata, Yoshinobu Hashizume, Masaaki Suzuki, Hirotaka Onoe, Yasuyoshi Watanabe, Hisashi Doi
Summary: Efficient synthesis of L-[5-C-11]leucine and L-alpha-[5-C-11]methylleucine was achieved using a two-step sequence, with promising potential of L-alpha-[5-C-11]methylleucine as a probe for visualizing tumors confirmed through tissue distribution analysis.
Article
Biochemistry & Molecular Biology
Chloe Laurencin, Sophie Lancelot, Ines Merida, Nicolas Costes, Jerome Redoute, Didier Le Bars, Philippe Boulinguez, Benedicte Ballanger
Summary: For the first time, [C-11]yohimbine was used to directly quantify alpha 2 adrenergic receptors (a(2)-ARs) availability in the living human brain. The results showed the highest binding in the hippocampus, occipital lobe, cingulate gyrus, and frontal lobe. Substantial variations in receptor binding within most structures were observed when the brain was divided into anatomical subregions.
Article
Biochemical Research Methods
Jinsoo Hong, Sanjay Telu, Yi Zhang, William H. Miller, H. Umesha Shetty, Cheryl L. Morse, Victor W. Pike
Summary: The production of radiotracers for human positron emission tomography studies needs to comply with current good manufacturing practice. This study demonstrates the translation of experimental radiosynthesis into a process that meets current good manufacturing practice guidelines, using the synthesis of [C-11]ER176 as an example.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, David Matuskey, Adam Mecca, Nabeel B. Nabulsi, David Labaree, Jim Ropchan, Robert T. Malison, Deepak Cyril D'Souza, Irina Esterlis, Kamil Detyniecki, Christopher H. van Dyck, Yiyun Huang, Richard E. Carson
Summary: This study compared SUVR-1 with BPND to select the optimal time window in healthy and neuropsychiatric subjects, finding that SUVR-1 showed greater correlation and less bias at later time windows. The 60-90 min period provided the best match between SUVR-1 and BPND.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pierre Courault, Sophie Lancelot, Nicolas Costes, Matthieu Colom, Didier Le Bars, Jerome Redoute, Florent Gobert, Frederic Dailler, Sibel Isal, Thibaut Iecker, Adrian Newman-Tancredi, Ines Merida, Luc Zimmer
Summary: This study characterizes the brain labeling of 5-HT1A receptors by [F-18]F13640 in humans and proposes a simplified model for its quantification. The results demonstrate high uptake values of [F-18]F13640 in raphe nuclei and cortical regions. The LREF method shows better reproducibility and reliability, and cerebellum white matter and frontal lobe white matter are identified as suitable reference regions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mika Naganawa, Nabeel Nabulsi, Shannan Henry, David Matuskey, Shu-Fei Lin, Lawrence Slieker, Adam J. Schwarz, Nancy Kant, Cynthia Jesudason, Kevin Ruley, Antonio Navarro, Hong Gao, Jim Ropchan, David Labaree, Richard E. Carson, Yiyun Huang
Summary: This study investigated the PET radiotracer C-11-LSN3172176 for M1 muscarinic acetylcholine receptors in healthy participants, finding that the 1TC and SRTM2 models are most suitable for quantitative analysis. The cerebellum was identified as a suitable reference region for the tracer. Overall, C-11-LSN3172176 demonstrated excellent test-retest reproducibility and holds promise for quantifying M1 receptors in the human brain.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Neurosciences
Ronan Yves Depoortere, Agnes Laure Auclair, Adrian Newman-Tancredi
Summary: NLX-101, a biased agonist at post-synaptic cortical 5-HT1A receptors, was found to protect against scopolamine-induced cognitive impairment, reversing deficits at 5 and 10 s delays. Compared to the acetylcholinesterase inhibitor tacrine, NLX-101 exhibited stronger and more dose-dependent effects.
Article
Oncology
Kazuhide Shimizu, Kaoru Tamura, Shoko Hara, Motoki Inaji, Yoji Tanaka, Daisuke Kobayashi, Takashi Sugawara, Hiroaki Wakimoto, Tadashi Nariai, Kenji Ishii, Ichiro Sakuma, Taketoshi Maehara
Summary: This study aimed to investigate the correlation between preoperative MET-PET signals and intraoperative 5-ALA-induced fluorescence in malignant brain tumor surgery. The results showed that strong tumor fluorescence correlated with high MET-PET uptake and cellular proliferation, providing valuable tumor biology information for surgery in situations where MET-PET is not accessible.
Article
Radiology, Nuclear Medicine & Medical Imaging
Manabu Kubota, Chie Seki, Yasuyuki Kimura, Keisuke Takahata, Hitoshi Shimada, Yuhei Takado, Kiwamu Matsuoka, Kenji Tagai, Yasunori Sano, Yasuharu Yamamoto, Maki Okada, Tatsuya Kikuchi, Masanori Ichise, Kazunori Kawamura, Ming-Rong Zhang, Makoto Higuchi
Summary: The study successfully visualized PDE7 in human brains using PET imaging with C-11-MTP38, demonstrating the potential of this novel ligand for quantitative investigation of central PDE7. The results showed high retentions in specific brain regions and the reversibility of C-11-MTP38 binding, with excellent agreements between different quantification methods, suggesting the practicality of MRTMO and SUVR for clinical use of C-11-MTP38-PET.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Biochemistry & Molecular Biology
Yasuyoshi Watanabe, Aya Mawatari, Kazuki Aita, Yuzuru Sato, Yasuhiro Wada, Takayoshi Nakaoka, Kayo Onoe, Emi Yamano, Go Akamatsu, Akihito Ohnishi, Keiji Shimizu, Masahiro Sasaki, Hisashi Doi, Michio Senda
Summary: This study investigated the whole-body pharmacokinetics of [C-11]TTFD in human healthy volunteers using PET imaging and radiation dosimetry. The results showed different uptake patterns of the compound in various tissues, with a relatively low effective radiation dose calculated.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Britt T. J. van Hagen, Nick P. van Goethem, Ellis Nelissen, Dean Paes, Karin Koymans, Scott van Hoof, Rudy Schreiber, Mark Varney, Adrian Newman-Tancredi, Jos Prickaerts
Summary: The aim of this study is to investigate the effects of pre- and post-synaptic 5-HT1A receptor activity on pattern separation. Male Wistar rats were treated acutely and chronically with 5-HT1AR biased agonists and their performance in object pattern separation (OPS) was measured. The results showed that acute treatment with F13714 impaired OPS performance, but chronic treatment normalized it. Acute and chronic treatment with NLX-101 enhanced OPS performance and caused an acute drop in body temperature. Chronic NLX-101 treatment increased the number of doublecortin positive neurons in the dorsal hippocampus.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jeff Zarp Petersen, Cristina Varo, Cecilie F. Skovsen, Caroline V. Ott, Hanne L. Kjaerstad, Eduard Vieta, Catherine J. Harmer, Gitte M. Knudsen, Lars V. Kessing, Julian Macoveanu, Kamilla W. Miskowiak
Summary: Cognitive impairment in bipolar disorder originates from the failure to recruit key regions in the cognitive control network (CCN) and to suppress task-irrelevant default mode network (DMN) activity during cognitive performance.
Article
Clinical Neurology
Amir G. Baroumand, Anca A. Arbune, Gregor Strobbe, Vincent Keereman, Lars H. Pinborg, Martin Fabricius, Guido Rubboli, Camilla Gobel Madsen, Bo Jespersen, Jannick Brennum, Otto Molby Henriksen, Pieter van Mierlo, Sandor Beniczky
Summary: This study presents the clinical validation of an automated EEG source imaging (ESI) for seizure EEG signals. The results show that the automated ESI has a high accuracy for localizing the seizure onset zone, which can facilitate its implementation in the presurgical evaluation.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Messoud Ashina, Michel Lanteri-Minet, Patricia Pozo-Rosich, Anders Ettrup, Cecilie Laurberg Christoffersen, Mette Krog Josiassen, Ravinder Phul, Bjorn Sperling
Summary: This study investigated the safety and efficacy of eptinezumab for patients with migraine and two-to-four previous preventive treatment failures, showing significant migraine preventive effects compared to placebo.
Article
Clinical Neurology
Patricia Pozo-Rosich, David W. Dodick, Anders Ettrup, Joe Hirman, Roger Cady
Summary: This post hoc analysis found that treatment with eptinezumab can reduce headache frequency and improve diagnostic category in migraine patients participating in the PROMISE clinical trials. This has important implications for reducing personal and societal burden.
Article
Biochemistry & Molecular Biology
Jens D. Mikkelsen, Sanjay S. Aripaka, Sif Kaad, Burcu A. Pazarlar, Lars Pinborg, Bente Finsen, Andrea Varrone, Benny Bang-Andersen, Jesper F. Bastlund
Summary: A newly developed radioligand [JNJ-64413739] that selectively binds to the purinergic receptor P2X7R has been found to detect neuroinflammation in the brain. The binding properties of JNJ-64413739 in human brain tissue were investigated, and it was found to have different binding abilities in gray and white matter. These findings demonstrate that JNJ-64413739 is suitable for evaluating the distribution and expression of P2X7R in the human brain.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Peter J. Goadsby, Piero Barbanti, Giorgio Lambru, Anders Ettrup, Cecilie Laurberg Christoffersen, Mette Krog Josiassen, Ravinder Phul, Bjorn Sperling
Summary: In a clinical trial, eptinezumab showed significant improvements in patient health and quality of life compared to placebo.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Gjertrud Louise Laurell, Pontus Plaven-Sigray, Annette Johansen, Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Jacob Madsen, Hanne Demant Hansen, Lene Lundgaard Donovan, Gitte Moos Knudsen, Adriaan A. Lammertsma, R. Todd Ogden, Claus Svarer, Martin Schain
Summary: The traditional design of PET target engagement studies involves baseline scan and subsequent scans after drug administration. Researchers propose an alternative design, the displacement study, where the drug is administered during an ongoing scan, resulting in reduced radiation exposure and costs. They develop kinetic models to analyze PET displacement data, modifying existing compartment models to accommodate time-variant increase in occupancy. Through simulations and application to PET data from pigs, the proposed models show promise in estimating target occupancy from a single displacement scan.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Medicine, General & Internal
Martin Prener, Giske Opheim, Zahra Shams, Christian Baastrup Sondergaard, Ulrich Lindberg, Henrik B. W. Larsson, Morten Ziebell, Vibeke Andree Larsen, Mark Bitsch Vestergaard, Olaf B. Paulson
Summary: In this exploratory study, the potential clinical implication of using single-voxel MRS at 7T to assess metabolic information on lesions in patients with grade II and III gliomas was evaluated. The findings showed significant changes in various metabolic ratios in glioma patients compared to healthy controls, as well as the presence of 2-HG. Evaluating metabolic information of gliomas is of significant importance in clinical practice.
Article
Medicine, General & Internal
Martin Prener, Giske Opheim, Helle Juhl Simonsen, Christina Malling Engelmann, Morten Ziebell, Jonathan Carlsen, Olaf B. Paulson
Summary: This study aimed to compare the gross tumor volume (GTV) in 7T and 3T MRI scans of diffuse low-grade gliomas (DLGGs). The results showed that GTVs delineated from 7T images were smaller, and increasing the field strength improved inter-observer agreement only on the FLAIR sequence.
Article
Pharmacology & Pharmacy
Xue-Ning Li, Hong-Rong Xu, Ellen Cui, Kamilla Buchberg Petersen, Janka Ryding, Anders Ettrup, Jette Buch Ostergaard, Frank Larsen
Summary: The pharmacokinetic profile of eptinezumab in healthy Chinese individuals was found to be similar to non-Asian populations with migraine. Eptinezumab was well tolerated in Chinese patients, with no new safety concerns identified. Evaluation of immunogenicity showed no impact of anti-drug antibodies or neutralizing antibodies on safety profiles, supporting the approved doses of 100 mg and 300 mg for Chinese patients with episodic or chronic migraine.
CLINICAL DRUG INVESTIGATION
(2023)
Article
Clinical Neurology
Siri A. Vulpius, Sebastian Werge, Isabella Friis Jorgensen, Troels Siggaard, Jorge Hernansanz Biel, Gitte M. Knudsen, Soren Brunak, Lars H. Pinborg
Summary: This study demonstrates that text mining of clinical notes can improve the accuracy of epilepsy diagnosis and classification of different epilepsy types for patients. It suggests that combining population-based health registries with electronic health records can be crucial for future precision medicine development for epilepsy patients.
Article
Clinical Neurology
Martin Prener, Veronica Drejer, Morten Ziebell, Per Jensen, Camilla Gobel Madsen, Svitlana Olsen, Gerda Thomsen, Lars H. H. Pinborg, Olaf B. B. Paulson
Summary: This retrospective study investigates the predictive value of ictal subtraction single-photon emission computed tomography (SPECT) co-registered to magnetic resonance imaging (MRI) (SISCOM) for successful epilepsy surgery. The results showed that the positive predictive value for good surgical outcome was 74.1% and 40% for different seizure durations.
Article
Clinical Neurology
Martin Prener, Veronica Drejer, Morten Ziebell, Per Jensen, Camilla Gobel Madsen, Svitlana Olsen, Gerda Thomsen, Lars H. Pinborg, Olaf B. Paulson
Summary: Reversed SISCOM performed better than conventional SISCOM at predicting good surgical outcomes. In approximately half of the cases, reversed SISCOM added additional value by either altering or confirming the conclusion. Sensitivity, positive predictive value (PPV), and odds ratio were better in the subgroup with longer seizure durations after injection (>30 s) and worse in the group with shorter durations (<30 s).
Article
Clinical Neurology
Messoud Ashina, Richard B. Lipton, Jessica Ailani, Jan Versijpt, Simona Sacco, Dimos D. Mitsikostas, Cecilie Laurberg Christoffersen, Bjorn Sperling, Anders Ettrup
Summary: This post hoc analysis suggests that eptinezumab can reduce monthly migraine days in patients with difficult-to-treat migraines. The majority of patients who responded to eptinezumab during the initial weeks maintained or improved their response during the later weeks. Additionally, a significant number of initial non-responders showed a response after the second infusion.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Orsolya Gyorfi, Cheng-Teng Ip, Anders Bach Justesen, Maria Louise Gam-Jensen, Connie Romer, Martin Fabricius, Lars H. Pinborg, Sandor Beniczky
Summary: This study aimed to evaluate the accuracy and feasibility of a handheld optical scanner for measuring high-density EEG electrode coordinates. The results showed that the optical scanner had a lower mean distance error compared to the photogrammetry method, and the real-time scanning time was shorter. The handheld optical scanner is suitable for EEG source imaging in the clinical setting.
CLINICAL NEUROPHYSIOLOGY PRACTICE
(2022)
