Article
Pharmacology & Pharmacy
Congwu Du, Yueming Hua, Kevin Clare, Kicheon Park, Craig P. Allen, Nora D. Volkow, Xiu-Ti Hu, Yingtian Pan
Summary: Individuals with substance use disorder are at a higher risk of contracting HIV and progressing to AIDS. Neurotoxicity and neurodegeneration are characteristic of HIV-1-associated neurocognitive disorders. Studies have found that cocaine potentiates the neurotoxic effects of HIV-associated proteins. The NMDA antagonist drug memantine shows potential in attenuating the neurotoxicity caused by cocaine and HIV.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Brittney Yegla, Asha Rani, Ashok Kumar
Summary: Age-associated decrease in NMDAR-mediated synaptic function contributes to cognitive impairments. Enhancing NMDAR function via increased SR expression in middle age rats improves learning and synaptic transmission. Prefrontal SR upregulation can improve visual discrimination and increase NMDAR activity.
Article
Psychiatry
Tiziana Imbriglio, Marika Alborghetti, Valeria Bruno, Giuseppe Battaglia, Ferdinando Nicoletti, Milena Cannella
Summary: The study found that TAAR1 mRNA levels were increased in the SCZ prefrontal cortex, with no correlation to various factors. Differences in TAAR1 protein levels were observed between neuropathological burden subgroups of CTRL, but not within the SCZ group. TAAR1 protein levels were lower in CTRL with low neuropathological burden compared to all SCZ samples or SCZ samples with low neuropathological burden. In the SCZ group, TAAR1 protein levels were inversely correlated with duration of antipsychotic treatment and higher in individuals treated with second-generation antipsychotics.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Hikaru Koizumi, Taichi Hiraga, Leandro K. Oharomari, Toshiaki Hata, Takeru Shima, Jang Soo Yook, Masahiro Okamoto, Akihiro Mouri, Toshitaka Nabeshima, Hideaki Soya
Summary: Schizophrenia may be attributed to perinatal neurodevelopmental deficits and influenced by environmental factors. Hypofrontality and dysfunction in glutamatergic and dopaminergic neurons are known factors, while early enriched environment and low-intensity exercise training during adolescence may help prevent and ameliorate the disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Anatomy & Morphology
Elizabeth Woo, Dibyadeep Datta, Amy F. T. Arnsten
Summary: mGlu3 receptors are mainly expressed in neurons and astrocytes in rat PL mPFC, and are also found in microglia to a lesser extent. They are predominantly located on axons and widely distributed in the glial membrane, but are also present on dendritic spines, particularly in layer III.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Biochemistry & Molecular Biology
Alma Hrnjadovic, James Friedmann, Sandra Barhebreus, Patricia J. Allen, Bernat Kocsis
Summary: The study aimed to investigate the role of 5-HT7 receptors in the reversal learning component of ASST and found that 5-HT7 receptor antagonist could reverse the impaired performance induced by NMDA receptor blockade, particularly affecting the reversal phases of ASST.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Neurosciences
Joseph A. McQuail, Sofia Beas, Kyle B. Kelly, Caesar M. Hernandez, Jennifer L. Bizon, Charles J. Frazier
Summary: The study revealed that loss of NMDARs on interneurons in the PFC contributes to age-related impairment of cognitive flexibility, while a clear increase in AMPA/NMDA ratio in FSIs suggests a potential underlying mechanism for cognitive decline. These findings provide new insights into the neural mechanisms of cognitive decline.
Article
Pharmacology & Pharmacy
Tsugumi Shindo, Hiroki Shikanai, Akane Watarai, Sachiko Hiraide, Kenji Iizuka, Takeshi Izumi
Summary: This study found that the dysfunction of D-serine metabolism associated with AD/HD leads to NMDA receptor dysfunction. Inhibiting DAAO enzyme can increase D-serine levels and improve AD/HD-like behaviors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Hristo Varbanov, Shaobo Jia, Gaga Kochlamazashvili, Subhrajit Bhattacharya, Manal Ali Buabeid, Mohamed El Tabbal, Hussam Hayani, Stoyan Stoyanov, Weilun Sun, Hauke Thiesler, Iris Roeckle, Herbert Hildebrandt, Oleg Senkov, Vishnu Suppiramaniam, Rita Gerardy-Schahn, Alexander Dityatev
Summary: Dysregulated cortical expression of NCAM and deficits of its associated polySia are found in Alzheimer's disease and schizophrenia. Acute enzymatic removal of polySia in the prefrontal cortex leads to increased transmission mediated by GluN1/GluN2B NMDARs, impaired LTP, and increased tonic currents. Treatment with polySia fragments or inhibition of GluN1/GluN2B receptors restores LTP and cognitive tasks in polySia-deficient mice and Alzheimer's disease models. The data highlight the crucial role of polySia-NCAM in balancing signaling through synaptic/extrasynaptic NMDARs and the therapeutic potential of polySia fragments.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Psychiatry
Shengtao Yang, Hyojung Seo, Min Wang, Amy F. T. Arnsten
Summary: The dlPFC generates mental representations through NMDAR transmission, while disruptions can lead to cognitive deficits. AMPAR plays a crucial role in visual stimuli and sensory event responses, whereas NMDAR is important for affective and visceral responses.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Behavioral Sciences
Sara Sabihi, Caitlin Goodpaster, Skyler Maurer, Benedetta Leuner
Summary: Mother-offspring interactions reduce postpartum anxiety-like behavior through GABAA neurotransmission in the mPFC. Activation of GABAA receptors in the mPFC restores anxiolysis in mothers separated from their pups, while an increased anxiety-like behavior in pup-separated mothers is associated with a lower number and percentage of activated GABAergic neurons in the mPFC.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Tong Zhao, XiaoLei Gao, Guang-Biao Huang
Summary: The study found that a portion of 6-OHDA lesioned mice exhibited more prominent stress response and social cognitive impairment under chronic social defeat stress, possibly due to decreased selectivity of D1 receptors in the amygdala.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biology
Geoffrey W. Diehl, A. David Redish
Summary: Decision-making requires different aspects of information and involves multiple cognitive processes. The rodent medial prefrontal cortex (mPFC) is believed to play a central role in these abilities. Previous studies on mPFC function have yielded controversial results, but this study with rats performing an economic decision task revealed four distinct functional domains within mPFC, closely related to anatomical subregions. Dorsal mPFC regions were more involved in processing active decisions, while ventral regions were more engaged in motivational factors.
Article
Health Care Sciences & Services
Atsumi Nitta, Naotaka Izuo, Kohei Hamatani, Ryo Inagaki, Yuka Kusui, Kequan Fu, Takashi Asano, Youta Torii, Chikako Habuchi, Hirotaka Sekiguchi, Shuji Iritani, Shin-ichi Muramatsu, Norio Ozaki, Yoshiaki Miyamoto
Summary: Suppressing Piccolo in the medial prefrontal cortex of mice leads to a reduction in synaptic proteins, electrophysiological impairments, and abnormal behaviors resembling those seen in schizophrenia.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Chitra Vinnakota, Anna Schroeder, Xin Du, Kazutaka Ikeda, Soichiro Ide, Masayoshi Mishina, Matthew Hudson, Nigel Charles Jones, Suresh Sundram, Rachel Anne Hill
Summary: This study investigated the role of the GluN2D subunit in mediating schizophrenia-relevant behaviors induced by a range of NMDAR antagonists. The results showed that GluN2D-KO mice exhibited abnormal locomotor activity, anxiety-related behavior, and memory, and the effects of NMDAR antagonists were dependent on sex and genotype.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Neurosciences
E. A. Kelly, T. M. Love, J. L. Fudge
Summary: Dopamine is involved in stress-related illnesses, and corticotropin-releasing factor plays a role in stress responses. This study examined the synaptic terminals between dopamine and non-dopamine cells and found that dopamine regulation may occur indirectly through contacts with non-dopamine neurons.