Article
Medicine, Research & Experimental
Roger L. Albin, Prabesh Kanel, Teus van Laar, Sygrid van der Zee, Stiven Roytman, Robert A. Koeppe, Peter J. H. Scott, Nicolaas Bohnen
Summary: This study examined the association between regional brain [F-18]FEOBV PET binding and the use of dopamine D2-like receptor agonist drugs in subjects with Parkinson's disease (PD). The results showed that chronic use of D2-like dopamine agonists in PD subjects did not lead to significant alterations in regional brain [F-18]FEOBV binding.
MOLECULAR PHARMACEUTICS
(2022)
Article
Neurosciences
Kyoungjune Pak, Lauri Nummenmaa
Summary: This study investigated the association between dopamine receptor availability and overweight/obesity using Bayesian and frequentist meta-analysis. The results showed that there was no difference in dopamine receptor availability between lean and overweight/obese subjects, but this effect was dependent on the radiopharmaceutical and the degree of obesity.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Andreas-Antonios Roussakis, Zhou Zeng, Nicholas P. Lao-Kaim, Antonio Martin-Bastida, Paola Piccini
Summary: The study found that in moderate-stage Parkinson's disease, asymmetry in striatal dopaminergic degeneration becomes less prominent over time, while the asymmetry of motor symptoms remains consistent between the clinically most and least affected body sides.
JOURNAL OF NEUROLOGY
(2021)
Review
Chemistry, Inorganic & Nuclear
Sebastien Schmitt, Emmanuel Moreau
Summary: This article reviews all the radiolabeling conditions with chelators used since 2009, aiming to determine the most efficient conditions for the rapid development of future radiotracers. Additionally, it focuses on the limitations of this strategy, particularly in terms of automation.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Veterinary Sciences
Su-Hyeon Kim, Sungin Lee
Summary: This case report describes the characteristics of 18F-FDG PET-CT imaging in a dog with an abdominal gossypiboma, which has not been reported in the veterinary literature before. A 13-year-old, spayed, female mixed breed dog underwent mastectomy and ovariohysterectomy and was referred for evaluation of metastasis after surgery. F-18-deoxy-2-D-glucose positron emission tomography/computed tomography (18F-FDG PET-CT) was performed and a soft-tissue mass was observed in the abdominal cavity.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Neurosciences
Kelly Smart, Mika Naganawa, Stephen R. Baldassarri, Nabeel Nabulsi, Jim Ropchan, Soheila Najafzadeh, Hong Gao, Antonio Navarro, Vanessa Barth, Irina Esterlis, Kelly P. Cosgrove, Yiyun Huang, Richard E. Carson, Ansel T. Hillmer
Summary: The study aimed to explore the variation of acetylcholine (Ach) across the human brain using positron emission tomography (PET) imaging estimates of drug occupancy at cholinergic receptors. Results showed consistently lower occupancy estimates within striatal regions, indicating higher ACh concentration, and provided the first in vivo estimates of regional variation in ACh concentration in the living brain.
Article
Neurosciences
Kyoji Okita, Koichi Kato, Yoko Shigemoto, Noriko Sato, Toshihiko Matsumoto, Hiroshi Matsuda
Summary: This study aims to investigate the impact of the A2A receptor antagonist istradefylline on dopamine D2-type receptor availability and impulsivity in the human brain, hypothesizing that it will increase D2-type BPND and improve impulsivity control. The double-blind, randomized controlled trial will involve 40 healthy participants receiving either istradefylline or placebo for two weeks, with PET scans and neuropsychological measurements conducted to evaluate the outcomes. The findings will be disseminated through peer reviewed scientific journals and conferences.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Marian Galovic, Kjell Erlandsson, Tim D. Fryer, Young T. Hong, Roido Manavaki, Hasan Sari, Sarah Chetcuti, Benjamin A. Thomas, Martin Fisher, Selena Sephton, Roberto Canales, Joseph J. Russell, Kerstin Sander, Erik Arstad, Franklin I. Aigbirhio, Ashley M. Groves, John S. Duncan, Kris Thielemans, Brian F. Hutton, Jonathan P. Coles, Matthias J. Koepp
Summary: Blood-based kinetic analysis of PET data relies on an accurate estimation of the arterial plasma input function. An alternative is the image-derived input function (IDIF), which can be corrected for the required free tracer concentration in plasma. The IDIF + venous method provides comparable results to arterial sampling, making it a viable alternative for quantification of V-T.
Article
Neurosciences
Hannah J. Zhang, Matthew Zammit, Chien-Min Kao, Anitha P. Govind, Samuel Mitchell, Nathanial Holderman, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski, Xiaoxi Zhuang, Jogeshwar Mukherjee, Chin-Tu Chen, William N. Green
Summary: The distribution of nicotine and other nicotinic receptor ligands in the brain is investigated. Ligands with high pKa and affinity for cc4P2Rs, like varenicline, are trapped in intracellular acidic vesicles in vitro, while nicotine, with lower pKa and affinity, is not trapped. In vivo imaging of PET ligands in mouse brain reveals that the trapping organelle is Golgi satellites (GSats) and provides insights into the subcellular distribution of these ligands.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Michael R. Kilbourn
Summary: The application of positron emission tomography (PET) imaging to study brain biochemistry, especially dopamine neurotransmission, has significantly grown over the past 40 years. PET imaging of dopaminergic functions in the central nervous system is routinely used for research in neurology, psychiatry, drug abuse and addiction, as well as drug development. The key advancement in PET imaging is the development of unique radiotracers labeled with positron-emitting radionuclides like carbon-11 and fluorine-18, which have greatly contributed to the progress in this field.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yong Du, Jennifer M. Coughlin, Mary Katherine Brosnan, Allen Chen, Laura K. Shinehouse, Rehab Abdallah, Martin A. Lodge, William B. Mathews, Chen Liu, Yunkou Wu, Il Minn, Paige Finley, Andrew W. Hall, Wojciech G. Lesniak, Robert F. Dannals, Andrew G. Horti, Martin G. Pomper
Summary: In this study, the safety and pharmacokinetic behavior of [C-11]MDTC in healthy human brain were evaluated using positron emission tomography (PET). The study found low expression of the cannabinoid receptor type 2 (CB2R) in the brain. Test-retest reliability of the receptor-binding outcomes showed a mean absolute variability of 9.91%. The results demonstrate the potential of [C-11]MDTC PET in assessing CB2R expression in the human brain.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Maxwell W. G. Miner, Heidi Liljenback, Jenni Virta, Semi Helin, Olli Eskola, Petri Elo, Jarmo Teuho, Kerttu Seppala, Vesa Oikonen, Guangli Yang, Andrea Kindler-Roehrborn, Heikki Minn, Xiang-Guo Li, Anne Roivainen
Summary: This study investigated the imaging capabilities of three PET imaging compounds in orthotopic BT4C gliomas in BDIX rats and compared two imaging systems. Results indicated that [F-18]FGln may offer improved imaging compared to [C-11]Met and [F-18]FDG, with similar end-result ratios between Inveon and Molecubes camera systems. Pharmacokinetic modeling suggested both reversible and irreversible uptake play an important role in the uptake of [F-18]FGln in BDIX rat pharmacokinetics.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Eugenii A. Rabiner, Roger N. Gunn
Summary: Positron emission tomography (PET) is essential for quantifying target engagement by brain targeting medications. Differences between repeated drug dosing (RD) and single drug dose (SD) studies may be related to changes in target density. Our findings suggest that target upregulation can explain the differences in drug affinity estimated in SD and RD studies. These findings have implications for understanding the relationship between target occupancy levels and drug efficacy and tolerability.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Hana Florian, Deli Wang, Steven E. Arnold, Merce Boada, Qi Guo, Ziyi Jin, Hui Zheng, Nahome Fisseha, Hari Varun Kalluri, Beatrice Rendenbach-Mueller, Kumar Budur, Michael Gold, Thomas Aware Investigators, Lealani Acosta, Thomas Ala, Sanka Amadoru, Jeffrey Apter, Steven Arnold, Merce Boada-Rovira, Anne Boerjesson-Hanson, Wendy Bond, Michael Borrie, Gabriella Bottini, Bruce Brew, Mark Brody, James Burke, Jeffrey Burns, Annalisa Chiari, Roger Clarnette, Sharon Cohen, Martin Farlow, Simon Fishman, Norman Foster, Kristian Frederiksen, Giovanni Frisoni, Nigel Gilchrist, Darren Gitelman, Ira Goodman, Marc Gordon, Neill Graff-Radford, Merja Hallikainen, Adrian Ivanoiu, Gregory Jicha, Michael Jonsson, Diana Kerwin, Dineke Koek, James Lah, Ayesha Lall, Elly Lee, Gabriel Leger, Peter Ljubenkov, Camillo Marra, Pablo Martinez-Lage, Joseph Masdeu, Scott McGinnis, Patrizia Mecocci, Philip Morris, Marshall Nash, Allison Perrin, Aimee Pierce, Robert Riesenberg, Juha Rinne, Raquel Sanchez Del Valle, Elio Scarpini, Paul Schulz, Ronald Schwartz, Amanda Smith, Bryan Spann, Sylvie Van Snick, Rik Vandenberghe, Cherian Verghese, Alberto Villarejo, Chuang-Kuo Wu
Summary: Tau accumulation in patients with Alzheimer's disease is closely related to cognitive decline. This study evaluated tilavonemab, an anti-tau monoclonal antibody, in treating patients with early Alzheimer's disease. The results showed that tilavonemab did not demonstrate efficacy in treating early Alzheimer's disease.
Article
Pharmacology & Pharmacy
Ying Zhang, Tao Wang, Xiaojun Zhang, Winnie Deuther-Conrad, Hualong Fu, Mengchao Cui, Jinming Zhang, Peter Brust, Yiyun Huang, Hongmei Jia
Summary: In this study, a series of indole-based derivatives were synthesized as novel sigma-2 receptor ligands, and two ligands with high affinity and selectivity were radiolabeled with F-18. Biodistribution studies in rodents showed that the radioligand [F-18]9 displayed high brain uptake and brain-to-blood ratio. Pre-treatment experiments and ex vivo autoradiography confirmed the specific binding of [F-18]9 to sigma-2 receptors in the brain. Dynamic positron emission tomography imaging further confirmed the regional distribution and specific binding of [F-18]9 in the rat brain.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Neuroimaging
Daniel S. Albrecht, Palmer J. MacKie, David A. Kareken, Gary D. Hutchins, Evgeny J. Chumin, Bradley T. Christian, Karmen K. Yoder
BRAIN IMAGING AND BEHAVIOR
(2016)
Article
Substance Abuse
Brandon G. Oberlin, Mario Dzemidzic, Jaroslaw Harezlak, Maria A. Kudela, Stella M. Tran, Christina M. Soeurt, Karmen K. Yoder, David A. Kareken
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2016)
Article
Substance Abuse
Melissa A. Cyders, J. Davis VanderVeen, Martin Plawecki, James B. Millward, James Hays, David A. Kareken, Sean O'Connor
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2016)
Article
Substance Abuse
Karmen K. Yoder, Daniel S. Albrecht, Mario Dzemidzic, Marc D. Normandin, Lauren M. Federici, Tammy Graves, Christine M. Herring, Karen L. Hile, James W. Walters, Tiebing Liang, Martin H. Plawecki, Sean O'Connor, David A. Kareken
DRUG AND ALCOHOL DEPENDENCE
(2016)
Article
Nutrition & Dietetics
R. Drew Sayer, Akua F. Amankwaah, Gregory G. Tamer, Ningning Chen, Amy J. Wright, Jason R. Tregellas, Marc-Andre Cornier, David A. Kareken, Thomas M. Talavage, Megan A. McCrory, Wayne W. Campbell
Article
Neurosciences
Jessica Weafer, Stephanie M. Gorka, Donald Hedeker, Mario Dzemidzic, David A. Kareken, K. Luan Phan, Harriet de Wit
NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Audiology & Speech-Language Pathology
Larry E. Humes, Sara E. Rogers, Tera M. Quigley, Anna K. Main, Dana L. Kinney, Christine Herring
AMERICAN JOURNAL OF AUDIOLOGY
(2017)
Article
Substance Abuse
Martin H. Plawecki, Kyle A. Windisch, Leah Wetherill, Ann E. K. Kosobud, Mario Dzemidzic, David A. Kareken, Sean J. O'Connor
Article
Neuroimaging
David A. Kareken
BRAIN IMAGING AND BEHAVIOR
(2019)
Article
Neuroimaging
William J. A. Eiler, Mario Dzemidzic, Christina M. Soeurt, Claire R. Carron, Brandon G. Oberlin, Robert V. Considine, Jaroslaw Harezlak, David A. Kareken
NEUROIMAGE-CLINICAL
(2018)
Article
Neurosciences
Brandon G. Oberlin, Mario Dzemidzic, William J. A. Eiler, Claire R. Carron, Christina M. Soeurt, Martin H. Plawecki, Nicholas J. Grahame, Sean J. O'Connor, David A. Kareken
PSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Maria A. Kudela, Mario Dzemidzic, Brandon G. Oberlin, Zikai Lin, Joaquin Goni, David A. Kareken, Jaroslaw Harezlak
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Mathematical & Computational Biology
Marta Karas, Damian Brzyski, Mario Dzemidzic, Joaquin Goni, David A. Kareken, Timothy W. Randolph, Jaroslaw Harezlak
STATISTICS IN BIOSCIENCES
(2019)
Article
Psychology, Experimental
Brendan T. Johns, Vanessa Taler, David B. Pisoni, Martin R. Farlow, Marie Hake, David A. Kareken, Frederick W. Unverzagt, Michael N. Jones
CANADIAN JOURNAL OF EXPERIMENTAL PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE EXPERIMENTALE
(2018)
Article
Psychology, Clinical
Melissa A. Cyders, Mario Dzemidzic, William J. Eiler, David A. Kareken
JOURNAL OF SEX RESEARCH
(2016)