Article
Pharmacology & Pharmacy
Congwu Du, Yueming Hua, Kevin Clare, Kicheon Park, Craig P. Allen, Nora D. Volkow, Xiu-Ti Hu, Yingtian Pan
Summary: Individuals with substance use disorder are at a higher risk of contracting HIV and progressing to AIDS. Neurotoxicity and neurodegeneration are characteristic of HIV-1-associated neurocognitive disorders. Studies have found that cocaine potentiates the neurotoxic effects of HIV-associated proteins. The NMDA antagonist drug memantine shows potential in attenuating the neurotoxicity caused by cocaine and HIV.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Anatomy & Morphology
Elizabeth Woo, Dibyadeep Datta, Amy F. T. Arnsten
Summary: mGlu3 receptors are mainly expressed in neurons and astrocytes in rat PL mPFC, and are also found in microglia to a lesser extent. They are predominantly located on axons and widely distributed in the glial membrane, but are also present on dendritic spines, particularly in layer III.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Neurosciences
Shayan Amiri, Rana Dizaji, Majid Momeny, Evan Gauvin, Mir-Jamal Hosseini
Summary: Recent evidence suggests that mitochondrial dysfunction and immune-inflammatory responses are involved in the pathophysiology of schizophrenia, in addition to abnormalities in the neurotransmitter hypothesis. The prefrontal cortex undergoes significant development during adolescence, a critical period vulnerable to environmental adversities and psychiatric disorders. Rat models of schizophrenia induced by post-weaning social isolation stress showed schizophrenic-like behaviors, mitochondrial dysfunction, and upregulation of immune-related genes in the PFC, and chronic treatment with clozapine attenuated these effects. These results may advance our understanding of the mechanisms through which clozapine acts on mitochondrial dysfunction and immune-inflammatory responses in schizophrenia.
Article
Neurosciences
Cristina Delgado-Sallent, Pau Nebot, Thomas Gener, Amanda B. Fath, Melina Timplalexi, M. Victoria Puig
Summary: Neural synchrony and functional connectivity are disrupted in schizophrenia. Atypical antipsychotic drugs, but not typical antipsychotic drugs, can reduce prefrontal and cortical-hippocampal hypersynchrony induced by psychosis-like states, suggesting that atypical antipsychotic drugs target prefrontal-hippocampal pathways for antipsychotic action. Serotonin receptors may play a selective role in the distinct effects of atypical antipsychotic drugs compared to typical antipsychotic drugs.
Article
Biology
Geoffrey W. Diehl, A. David Redish
Summary: Decision-making requires different aspects of information and involves multiple cognitive processes. The rodent medial prefrontal cortex (mPFC) is believed to play a central role in these abilities. Previous studies on mPFC function have yielded controversial results, but this study with rats performing an economic decision task revealed four distinct functional domains within mPFC, closely related to anatomical subregions. Dorsal mPFC regions were more involved in processing active decisions, while ventral regions were more engaged in motivational factors.
Article
Health Care Sciences & Services
Atsumi Nitta, Naotaka Izuo, Kohei Hamatani, Ryo Inagaki, Yuka Kusui, Kequan Fu, Takashi Asano, Youta Torii, Chikako Habuchi, Hirotaka Sekiguchi, Shuji Iritani, Shin-ichi Muramatsu, Norio Ozaki, Yoshiaki Miyamoto
Summary: Suppressing Piccolo in the medial prefrontal cortex of mice leads to a reduction in synaptic proteins, electrophysiological impairments, and abnormal behaviors resembling those seen in schizophrenia.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Brittney Yegla, Asha Rani, Ashok Kumar
Summary: Age-associated decrease in NMDAR-mediated synaptic function contributes to cognitive impairments. Enhancing NMDAR function via increased SR expression in middle age rats improves learning and synaptic transmission. Prefrontal SR upregulation can improve visual discrimination and increase NMDAR activity.
Article
Psychiatry
Tiziana Imbriglio, Marika Alborghetti, Valeria Bruno, Giuseppe Battaglia, Ferdinando Nicoletti, Milena Cannella
Summary: The study found that TAAR1 mRNA levels were increased in the SCZ prefrontal cortex, with no correlation to various factors. Differences in TAAR1 protein levels were observed between neuropathological burden subgroups of CTRL, but not within the SCZ group. TAAR1 protein levels were lower in CTRL with low neuropathological burden compared to all SCZ samples or SCZ samples with low neuropathological burden. In the SCZ group, TAAR1 protein levels were inversely correlated with duration of antipsychotic treatment and higher in individuals treated with second-generation antipsychotics.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Paula Kaanders, Hamed Nili, Jill X. O'Reilly, Laurence Hunt
Summary: In this study using fMRI, researchers investigate the neural basis of information sampling in economic choice. The activity of the medial frontal cortex (MFC) was found to predict further information sampling, while a distributed network of regions across the prefrontal cortex encoded key features of the sampled information.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Ellen P. Woon, Laura M. Butkovich, Arianna A. Peluso, Aziz Elbasheir, Kian Taylor, Shannon L. Gourley
Summary: We have discovered a connection between the ventral hippocampus and the medial orbitofrontal cortex that plays an important role in the updating of value memories, and this connection is mediated by the neuroplasticity-associated neurotrophin receptor TrkB.
Article
Biochemistry & Molecular Biology
Hidekazu Sotoyama, Hiroyoshi Inaba, Yuriko Iwakura, Hisaaki Namba, Nobuyuki Takei, Toshikuni Sasaoka, Hiroyuki Nawa
Summary: Dopamine in the prefrontal cortex has opposing effects on social behavior depending on the duration of its activation. Sustained dopamine activation suppresses social behavior while acute activation enhances it. The duration of social interactions is positively correlated with transient dopamine release and negatively correlated with sustained dopamine increase in the prefrontal cortex. Dopamine levels also modulate neural calcium signaling and c-Fos induction triggered by social stimuli in prefrontal neurons.
Article
Neurosciences
Wen-Jing Ren, Ya-Fei Zhao, Jie Li, Patrizia Rubini, Zeng-Qiang Yuan, Yong Tang, Peter Illes
Summary: This study found that in a mouse model of major depressive disorder, depression-like behavior can be aggravated by microinjecting the P2X7R agonist ATP or its analog dibenzoyl-ATP into the medial prefrontal cortex, and this effect can be reversed by the P2X7R antagonist JNJ-47965567.
Article
Biochemistry & Molecular Biology
Alma Hrnjadovic, James Friedmann, Sandra Barhebreus, Patricia J. Allen, Bernat Kocsis
Summary: The study aimed to investigate the role of 5-HT7 receptors in the reversal learning component of ASST and found that 5-HT7 receptor antagonist could reverse the impaired performance induced by NMDA receptor blockade, particularly affecting the reversal phases of ASST.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Neurosciences
Tyler D. Dexter, Daniel Palmer, Ahmed M. Hashad, Lisa M. Saksida, Tim J. Bussey
Summary: Working memory is a crucial cognitive process for decision-making and is often impaired in various neuropsychiatric and neurodegenerative diseases. Researchers have used the TUNL task to assess spatial working memory in rodents and investigate its neurobiology. By optimizing the TUNL protocol, they have enabled mice to accurately perform this task and reduced the development of unwanted strategies. Through pharmacological experiments, they discovered the roles of the medial prefrontal cortex (mPFC) and N-methyl-D-aspartate (NMDA) receptor in controlling TUNL performance.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Jonas-Frederic Sauer, Shani Folschweiller, Marlene Bartos
Summary: The study reveals the emergence of a dynamic and topographically organized place code in the medial prefrontal cortex of mice during spontaneous locomotion. This representation discriminates between familiar and novel environments and is reinstated upon reexposure to the same familiar environment. The topographical analysis shows a dorsoventral gradient in the representation of the own position, which is opposite to the innervation density of hippocampal inputs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Monica M. Marcus, Charlotte Wiker, Olivia Franberg, Asa Konradsson-Geuken, Xavier Langlois, Kent Jardemark, Torgny H. Svensson
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2010)
Article
Clinical Neurology
Dimitri De Bundel, Teresa Femenia, Caitlin M. DuPont, Asa Konradsson-Geuken, Kritin Feltmann, Bjorn Schilstrm, Maria Lindskog
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Clinical Neurology
Carl Bjorkholm, Olivia Franberg, Anna Malmerfelt, Monica M. Marcus, Asa Konradsson-Geuken, Bjorn Schilstrom, Kent Jardemark, Torgny H. Svensson
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Clinical Neurology
Torun Malmlof, Kristin Feltmann, Asa Konradsson-Geuken, Frank Schneider, Rudolf-Giesbert Alken, Torgny H. Svensson, Bjorn Schilstrom
JOURNAL OF NEURAL TRANSMISSION
(2015)
Article
Neurosciences
A. Konradsson-Geuken, H. Q. Wu, C. R. Gash, K. S. Alexander, A. Campbell, Y. Sozeri, R. Pellicciari, R. Schwarcz, J. P. Bruno
Article
Neurosciences
Asa Konradsson-Geuken, Clelland R. Gash, Kathleen Alexander, Francois Pomerleau, Peter Huettl, Greg A. Gerhardt, John P. Bruno
Article
Neurosciences
Bjorn Schilstrom, Asa Konradsson-Geuken, Vladimir Ivanov, Jens Gertow, Kristin Feltmann, Monica M. Marcus, Kent Jardemark, Torgny H. Svensson
Article
Neurosciences
Monica M. Marcus, Kent Jardemark, Anna Malmerfelt, Jens Gertow, Asa Konradsson-Geuken, Torgny H. Svensson
Article
Neurosciences
Olivia Franberg, Charlotte Wiker, Monica M. Marcus, Asa Konradsson, Kent Jardemark, Bjorn Schilstrom, Mohammed Shahid, Erik H. F. Wong, Torgny H. Svensson
PSYCHOPHARMACOLOGY
(2008)
Article
Neurosciences
Asa Konradsson, Monica M. Marcus, Peter Hertel, Torgny H. Svensson, Kent E. Jardemark
Article
Clinical Neurology
K Jardemark, MM Marcus, Å Konradsson, TH Svensson
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2005)
Article
Neurosciences
E. A. Kelly, T. M. Love, J. L. Fudge
Summary: Dopamine is involved in stress-related illnesses, and corticotropin-releasing factor plays a role in stress responses. This study examined the synaptic terminals between dopamine and non-dopamine cells and found that dopamine regulation may occur indirectly through contacts with non-dopamine neurons.