Article
Biochemistry & Molecular Biology
Anna Kruyer, Jeffrey Parrilla-Carrero, Courtney Powell, Lasse Brandt, Stefan Gutwinski, Ariana Angelis, Reda M. Chalhoub, Thomas C. Jhou, Peter W. Kalivas, Davide Amato
Summary: Antipsychotic-induced dopamine supersensitivity is a problematic consequence of long-term antipsychotic treatment, characterized by motor abnormalities, refractory symptoms, and rebound psychosis. This phenomenon is associated with long-lasting synaptic plasticity and hyperexcitability in a subpopulation of D2 receptor-expressing neurons, leading to behavioral endophenotypes of treatment resistance and substance use disorder. Chemogenetic restoration of inhibitory postsynaptic currents may offer a novel therapeutic direction for preventing antipsychotic-induced supersensitivity.
MOLECULAR PSYCHIATRY
(2021)
Article
Behavioral Sciences
Makoto Kimura, Yasunori Oda, Hiroshi Kimura, Masahito Nangaku, Yuki Hirose, Tomihisa Niitsu, Nobuhisa Kanahara, Yukihiko Shirayama, Kenji Hashimoto, Masaomi Iyo
Summary: The study found significantly decreased levels of dopamine in DSS rats, as well as impaired basal dopamine release and AKT/ GSK-3 signaling functions.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Psychology, Clinical
Martin Harrow, Thomas H. Jobe, Liping Tong
Summary: This study questions the use of continuous antipsychotic medications, finding better outcomes for participants with schizophrenia and affective psychosis not on antipsychotics after the second year. The absence of antipsychotics predicts a higher probability of recovery and lower probability of rehospitalization regardless of diagnosis, emphasizing the importance of further research on the role of medications in mental illness treatment.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
William Lugg
Summary: The concept of antipsychotic-induced 'supersensitivity' may increase vulnerability to psychotic relapse, leading to the need for further research and adjustments in clinical practice.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Chia-Hao Ma, Hung-Yu Chan, Ming H. Hsieh, Chen-Chung Liu, Chih-Min Liu, Hai-Gwo Hwu, Ching-Hua Kuo, Wei J. Chen, Tzung-Jeng Hwang
Summary: The study found that higher doses of original antipsychotics and prescription of first-generation antipsychotics may be associated with an increased risk of aripiprazole-related psychotic exacerbation. Identifying high-risk patients and guiding appropriate treatment strategies is crucial based on these findings.
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dorothea Ziemens, Chadi Touma, Virginie Rappeneau
Summary: This literature review discusses the impact of high-fat diets on emotionality, cognition, and reward-related behavior in rodents, as well as its effects on brain metabolism and plasticity. The review highlights the clear impact of high-fat diets on behavior and underlying brain processes, but notes that most studies have focused on male rodents and further research is needed to investigate the biological impact on female rodents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xiao-Yu Liu, Li-Fei Zheng, Yan-Yan Fan, Qian-Ying Shen, Yao Qi, Guang-Wen Li, Qi Sun, Yue Zhang, Xiao-Yan Feng, Jin-Xia Zhu
Summary: In this study, the researchers investigate the effect of dopamine on gastric pepsinogen secretion through dopamine receptors expressed on chief cells or potential D2 receptors expressed on D cells. The findings suggest that dopamine promotes gastric pepsinogen secretion directly through D1-like receptors on chief cells and indirectly through D2 receptor-mediated suppression of somatostatin release.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yarim Elideth De la Luz-Cuellar, Ulises Coffeen, Francisco Mercado, Vinicio Granados-Soto
Summary: This study investigated the impact of sex on the antiallodynic activity of spinal dopamine D1 and D2-like receptors in a model of fibromyalgia-type pain in rats. The results showed that drugs targeting these receptors had a greater effect on female rats compared to male rats. Sex differences were also observed in a nerve injury model. These findings suggest that the antiallodynic effect of dopamine receptors in fibromyalgia-type pain is influenced by hormonal receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Richard B. Mailman, Yang Yang, Xuemei Huang
Summary: Research suggests that selective D-1 agonists may play a critical role in the treatment of Parkinson's disease, providing profound symptomatic relief even when current drugs are ineffective. Existing Parkinson's medications have limited efficacy in severe cases, but high intrinsic activity D-1 agonists could offer a major therapeutic advance in improving patients' quality of life.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
B. F. G. Queiroz, F. C. S. Fonseca, R. C. M. Ferreira, T. R. L. Romero, A. C. Perez, I. D. G. Duarte
Summary: This study investigated the role of dopamine and its receptors in the peripheral processing of the nociceptive response in mice using a pharmacological approach and the paw pressure test. The results showed that dopamine at small doses produced antinociceptive effects via the activation of D-2-like receptors, while at higher doses it caused hyperalgesia via the activation of D-1-like receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Adiba Anam, Sean Lynch, Nafiz Mosharraf, Chloe Soukas, Dmitriy Gekhman
Summary: Schizophrenia is a common psychiatric illness with significant economic and social burden. Second generation antipsychotics, including Aripiprazole, Risperidone, and Paliperidone, have changed treatment practices for psychiatrists. Aripiprazole has high affinity for the dopamine D2 receptor, which is responsible for the antipsychotic effect, but may not be as potent as other second generation antipsychotics. This case study explores how Aripiprazole may worsen psychiatric symptoms by blocking the antipsychotic effects of Paliperidone due to its strong binding affinity for the D2 receptor. Prescribers should be cautious when initiating long-acting injectable forms of Aripiprazole to avoid this phenomenon.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Aviv M. Weinstein
Summary: The study aimed to evaluate the dopamine receptor D-2 availability in the striatum of individuals recovering from cannabis-induced psychosis and compare it with MDMA abusers and healthy controls. The results showed no difference in dopamine D-2 receptor availability between the cannabis abstinent users and the MDMA abusers and healthy controls, suggesting minimal effects of cannabis-induced psychosis on dopamine reward mechanisms.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Behavioral Sciences
William B. Foster, Katherine F. Beach, Paige F. Carson, Kagan C. Harris, Brandon L. Alonso, Leo T. Costa, Roy C. Simamora, Jaclyn E. Corbin, Keegan F. Hoag, Sophia I. Mercado, Anya G. Bernhard, Cary H. Leung, Eric J. Nestler, Laura E. Been
Summary: In placental mammals, elevated levels of estradiol during pregnancy decrease rapidly after birth, potentially leading to an estrogen withdrawal state that affects affective states in the postpartum period. The neural mechanisms underlying these affective changes are not well studied.
HORMONES AND BEHAVIOR
(2023)
Article
Neuroimaging
U. Sauerzopf, A. Weidenauer, I Dajic, M. Bauer, L. Bartova, B. Meyer, L. Nics, C. Philippe, S. Pfaff, V Pichler, M. Mitterhauser, W. Wadsak, M. Hacker, S. Kasper, R. Lanzenberger, L. Pezawas, N. Praschak-Rieder, M. Willeit
Summary: The fundamental role of brain dopamine is to coordinate cognitive and motor resources for efficient use of environmental energy sources. In patients with first-episode psychosis, there is a negative relationship between blood glucose levels and brain dopamine signaling, possibly reflecting a underlying pathological change. Unlike healthy volunteers, patients show a reversed relationship between dopamine signaling and glucose homeostasis.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Bai-Lin Song, Jie Zhou, Yi Jiang, Lai-Fu Li, Ying-Juan Liu
Summary: The dopamine system and the lateral septum play important roles in social hierarchies. Mice living in social groups form linear dominance hierarchies, with subordinates showing increased anxiety. D2 receptors in the intermediate region of the lateral septum are elevated in subordinates, and pharmacological studies show that simultaneous D2 receptor activation in dominants and inhibition in subordinates can switch the original dominant-subordinate relationship.
Article
Clinical Neurology
Nicola Simola, Elena Paci, Marcello Serra, Giulia Costa, Micaela Morelli
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Giulia Costa, Micaela Morelli, Nicola Simola
NEUROTOXICITY RESEARCH
(2017)
Article
Behavioral Sciences
Nicola Simola, Giulia Costa
BEHAVIOURAL BRAIN RESEARCH
(2018)
Article
Biochemical Research Methods
Nicola Simola, Stefan M. Brudzynski
JOURNAL OF NEUROSCIENCE METHODS
(2018)
Article
Neurosciences
Giulia Costa, Micaela Morelli, Nicola Simola
NEUROTOXICITY RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Simo S. Zulu, Nicola Simola, Musa V. Mabandla, William M. U. Daniels
JOURNAL OF CHEMICAL NEUROANATOMY
(2018)
Review
Neurosciences
Nicola Simola, Sylvie Granon
Article
Neurosciences
Giulia Costa, Marcello Serra, Nicholas Pintori, Maria Antonietta Casu, Mary Tresa Zanda, Daniela Murta, Maria Antonietta De Luca, Nicola Simola, Liana Fattore
Article
Neurosciences
Aurora Musa, Nicola Simola, Gessica Piras, Francesca Caria, Emmanuel Shan Onaivi, Maria Antonietta De Luca
Article
Neurosciences
Giulia Costa, Stefan Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morelli
Summary: The study suggests that prenatal exposure to glucocorticoids may increase the susceptibility to central toxicity of amphetamine-related drugs used later in life in an age-dependent manner. Prenatal exposure to high levels of glucocorticoids induced dopaminergic damage and glia activation when the offspring were later treated with the psychoactive drug MDMA.
Article
Pharmacology & Pharmacy
Nicholas Pintori, Maria Paola Castelli, Cristina Miliano, Nicola Simola, Paola Fadda, Liana Fattore, Maria Scherma, Maria Grazia Ennas, Rafaela Mostallino, Giovanna Flore, Marta De Felice, Claudia Sagheddu, Marco Pistis, Gaetano Di Chiara, Maria Antonietta De Luca
Summary: Repeated exposure to JWH-018 induced anxious and aversive behaviors, decreased dopamine neurons in the VTA, and altered dopaminergic transmission. The drug also affected dopamine sensitivity in the NAc shell and core, while causing neuroinflammatory responses in specific brain areas. This study suggests that recurring use of Spice/K2 drugs may have detrimental effects on behavior and dopamine regulation.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Marcello Serra, Jacopo Marongiu, Nicola Simola
Summary: The study evaluated the emission of ultrasonic vocalizations in C57BL/6J mice after repeated treatment with amphetamine and dopamine receptor agonist. The results showed that mice emitted USVs during social contacts, but did not significantly vocalize after drug administration or drug-paired environmental cues.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Giulia Costa, Marcello Serra, Nicola Simola
Summary: The study found that rats emitted different frequencies of USVs during tickling, novel object recognition test (NOR), and single trial continuous spontaneous alternation behavior (SAB) test, but this calling behavior was not linked with behavioral readouts indicative of memory function. However, rats that predominantly emitted 22-kHz USVs during tickling displayed impaired performance in the NOR test.
Editorial Material
Neurosciences
Andrea Grignolio, Micaela Morelli, Marco Tamietto
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Maria Francesca Palmas, Michela Etzi, Augusta Pisanu, Chiara Camoglio, Claudia Sagheddu, Michele Santoni, Maria Francesca Manchinu, Mauro Pala, Giuliana Fusco, Alfonso De Simone, Luca Picci, Giovanna Mulas, Saturnino Spiga, Maria Scherma, Paola Fadda, Marco Pistis, Nicola Simola, Ezio Carboni, Anna R. Carta
Summary: The study demonstrates that intracerebral infusion of pre-formed human alpha synuclein oligomers (H-alpha SynOs) provides a valid model for studying cognitive symptoms in Parkinson's disease, accompanied by neuroinflammation, shedding light on the mechanisms underlying cognitive impairment.
Article
Neurosciences
E. A. Kelly, T. M. Love, J. L. Fudge
Summary: Dopamine is involved in stress-related illnesses, and corticotropin-releasing factor plays a role in stress responses. This study examined the synaptic terminals between dopamine and non-dopamine cells and found that dopamine regulation may occur indirectly through contacts with non-dopamine neurons.
